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Azidohydroxylation of 1-carbamoyl, 1-methoxycarbonyl and 1-cyano substituted d-lyxo and d-arabino configured O-peracylated glycals was studied and the reaction conditions were optimized. Under these conditions (3 equiv. NaN3/2 equiv. PIFA/0.3 equiv. TEMPO/50 equiv. H2O/dry DCM/0 °C/Ar) the expected 3-azido-3-deoxy ulopyranosonic acid derivatives were isolated in good yield with α-d-galacto configuration exclusively from the reaction of the 1-carbamoyl and 1-methoxycarbonyl substituted d-lyxo configured O-peracetylated glycals, while the transformation of the 1-cyano derivative gave a 2,3-vicinal diazide in low yield. The 1-carbamoyl d-arabino configured O-perbenzoylated glycal gave a mixture of α-d-gluco and α-d-manno configured azidohydroxylated products with d-gluco preference. The analogous 1-methoxycarbonyl derivative gave an inseparable product mixture and no transformation was detected with the respective 1-cyano glycal.

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In response to the increasing demand for voice, data, and multimedia applications, the next generation of wireless communication systems is projected to provide faster data rates and better service quality to customers. Techniques such as Multiple-Input-Multiple-Output (MIMO) and diversity are being studied and implemented to meet the needs of next-generation wireless communication systems. Embedding multiple antennas into the same antenna system is seen as a promising solution, which can improve both the system's channel capacity and the communication link's quality. However, for small handheld and portable devices, embedding many antennas into a single device in a small area and at the same time providing good isolation becomes a challenge. Hence, designing a shared antenna system with multiple feed ports with equivalent or better performance characteristics as compared to the approach of multiple antennas with multiple feed ports is a promising advantage which can reduce the size and cost of manufacturing. This paper intends to provide an in-depth review of different MIMO antenna designs with common radiators covering various antenna design aspects such as isolation techniques, gain, efficiency, envelope correlation coefficient, and size, etc. There is also a discussion of the mathematical concepts of MIMO and different isolation techniques, as well as a comparative analysis of different shared radiator antenna designs. The literature review shows that only very few antennas' design with common radiator have been suggested in the available literature at present. Therefore, in this review paper, we have endeavored to study different antennas' designs with common radiator. A comparison is provided of their performance improvement techniques in a holistic way so that it can lead to further develop the common radiator multiport antenna systems and realize the promising advantages they offer.

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On the way from the Internet of things (IoT) to the Internet of underground things (IoUT) the main challenge is antenna design. The enabling technologies still rely on simple design and low cost, but the systems are more complex. The LoRa-based system combined with a machine learning approach can be used for the estimation of soil moisture by using signal strength data, but for the improvement of the system performance we propose the optimization of the antenna for underground use. The soil properties are frequency-dependent and varying in time, which may cause variations in the signal wavelength and input impedance of the antenna underground. Instead of using wideband antenna design or standard helical antenna provided in LoRa module, which are typical in the IoUT research community for communication links, we propose a narrow-band antenna design for the application in soil moisture sensing. It is shown that the approach of simply matching the antenna buried in dry sand can provide a substantial signal level difference, ranging from approximately 10 dB (achieved by proof-of-concept measurements) to as much as 40 dB (calculated by a full wave simulator) in reflection coefficient when the moisture content is being increased by 20%. This can ensure more reliable radio sensing in novel sensorless technology where soil moisture information is extracted from the signal strength of a transmitting device.

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An implantable stacked planar inverted-F antenna (PIFA) for biotelemetric communication in the 402-405 MHz Medical Implant Communications Service (MICS) frequency band is designed and fabricated. With the proposed PIFA structure, a slot on each radiating patch was embedded, resulting in a size reduction of 0.013 λ and a compact size of 10 × 10 × 1.905 mm3. Both in vitro and in vivo experiments verified the simulation performance with characteristics of -10 dB bandwidth of 29 MHz, radiation efficiency of 0.9%, and a maximum far-field gain of -18.8 dB. We calculated the safety power delivered to the antenna using the specific absorption rate (SAR) limitation standard. Compared to other implantable antennas for biotelemetry, this antenna performs comparably and has a smaller size. This design would further develop implantable medical devices that communicate in the MICS band.

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To discover an efficient and convenient method to synthesize C2-arylacylated benzothiazoles as potential drug scaffolds, a novel [bis(trifluoroacetoxy)iodo]benzene(PIFA)/KOH synergistically promoted direct ring-opening C2-arylacylation reaction of 2H-benzothiazoles with aryl methyl ketones has been developed. Various substrates were tolerated under optimized conditions affording the C2-arylacylation products in 70-95% yields for 38 examples. A plausible mechanism was also proposed based on a series of controlled experiments.

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This study investigated glass ceramics produced using coal gasification slag (CGS) and petrochemical incineration fly ash (PIFA) to immobilize hazardous heavy metals such as Cr and As. However, the crystallization kinetics and stabilization behavior mechanism of different heavy metals in the petrochemical incineration fly ash-derived glass-ceramics remains unclear. And X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and inductively coupled plasma mass spectrometry were used to characterize glass and crystalline products. In this paper, we reported the crystallization kinetics and chemical leaching characteristics of the glass ceramic. A low crystallization activation energy of 121.49 kJ/mol was achieved from crystallization peak of several different heating rates around 850°C, implying that it is easier to produce the glass ceramics at that temperature. The Avrami parameter of the former crystallization was determined to be 1.23 ± .12, which indicated two-dimensional crystal growth with heterogeneous nucleation. The toxicity characteristic leaching procedure results indicated that the heavy metals were well solidified, and that the leaching concentration was significantly lower than the limit specified by governmental agencies. The potentially toxic element index of the parent glass and the two glass ceramics were 11.7, 5.8, and 3.6, respectively. Therefore, the conversion of hazardous petrochemical incineration fly ash and other solid waste into environmentally friendly glass ceramics shows considerable potential and reliability.

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A regioselective method for the synthesis of 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones - close structural analogs of naturally occurring vasicinone alkaloids - is described. The procedure is based on PIFA-initiated oxidative 5-exo-trig cyclization of 2-(3-butenyl)quinazolin-4(3Н)-ones, in turn prepared by thermal cyclocondensation of the corresponding 2-(pent-4-enamido)benzamides. The products obtained have a good natural product likeness (NPL) score and therefore can be useful for the design of natural product-like compound libraries.

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Moisture causes detuning and increased losses in textile antennas, and it affects resonant and wideband textile antennas differently. In this work, we studied the effect of moisture on a resonant textile planar inverted-F antenna (PIFA) and a wideband textile monopole antenna. Both antennas were manufactured by embroidering conductive yarn in denim textile. The input reflection coefficient, antenna gain, and gain patterns were measured on both antennas for different moisture contents. The results show that wideband antennas are less affected by moisture in comparison with resonant antennas. For communications applications, large moisture content in the textile antenna should be avoided; therefore a flexible, textile-based waterproofing antenna cover was proposed, manufactured, and tested. On the other hand, the effect of antenna detuning by moisture can be used for moisture-sensing application. This concept was demonstrated on the resonant textile PIFA in transmission and reflection setups, showing that the reflection setup gives better results.

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In this study, a new design of a tri-band multiple-input-multiple-output (MIMO) antenna array is proposed for fifth-generation (5G) cellular systems. Its structure is composed of eight identical planar-inverted F antenna (PIFA) elements placed at different edge corners of the handset mainboard with overall dimensions of 150 × 75 mm2. The PIFA elements and ground plane of the MIMO antenna system are arranged on the back layer of the platform, which makes the design easy to integrate with the handset circuit. For S11 ≤ -10 dB, the radiation elements of the MIMO design operate at the frequency ranges of 2.5-2.7 GHz, 3.4-3.75 GHz, and 5.6-6 GHz covering the long-term evolution (LTE) 41, 42/43, and 47 operation bands, respectively. The array achieves better than 15 dB return loss results across the three operating bands. The presented antenna array not only exhibits multi-band operation but also generates the polarization diversity characteristic, which makes it suitable for multi-mode operation. The proposed antenna array was simulated and experimentally tested. Fundamental characteristics of the proposed design are investigated. It offers three band S-parameters with acceptable isolation and dual-polarized radiation with quite good efficiency and gain results. Besides this, the total active reflection coefficient (TARC) and envelope correlation coefficient (ECC) results of the PIFAs are very low over the bands. In addition, the radiation characteristics of the MIMO antenna in the presence of the user and handset components are studied. Moreover, a new and compact phased array millimeter-wave (MM-Wave) antenna with broad bandwidth and end-fire radiation is introduced which can be easily integrated into the smartphone antenna system. Due to its good performance and simple structures, the proposed smartphone antenna array design is a good candidate for future multi-mode 5G cellular applications.

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This paper presents the design, simulation, and fabrication of a 50 Ohm miniaturized rectenna for wireless energy harvesting for leadless pacemakers. The paper evaluates the performance of each section separately and also while cascaded. The system is designed to work at ultra-low RF input power. When the rectenna is placed 5 cm away from the body surface in simulations, the amount of received power is approximately -20 dBm. The proposed antenna is a miniature spiral PIFA with circular polarization at 673 MHz. The measured results, in and outside sheep's fat tissue, show that about 15 MHz bandwidth can be realized with [Formula: see text] below -10 dB and an axial ratio below 3 dB. Two types of rectifiers are fabricated and compared to choose the best one for such a system. Then, unlike most other researches which selected the doubler rectifier structure, this paper uses a single-diode rectifier structure at this power level. The rectenna can be encapsulated in a cylinder with a radius of 5 mm and a height of 3.2 mm. The efficiency of the rectenna reaches 40% at -20 dBm input power.

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This paper proposes a microfluidic impedance tuner that is applied to a planar inverted-F antenna (PIFA). The proposed microfluidic impedance tuner is designed while using a simple double-stub and the impedance is changed by tuning the stub length. In this work, the stub length can be tuned by injecting a liquid metal alloy to the microfluidic channels. Initially, the PIFA operates at 900 MHz with impedance matching of 50 Ω. The impedance is mismatched when a hand is placed close to the antenna. The mismatched impedance is matched to 50 Ω by injecting the liquid metal alloy. The antenna is fabricated on the FR-4 substrate, and the impedance tuner is fabricated on polydimethylsiloxane (PDMS). In order to inject the liquid metal alloy, a piezoelectric micropump and microprocessor are used in the measurement. At 900 MHz, the return loss is successfully tuned from 4.69 dB to 18.4 dB when a hand is placed 1 mm above the antenna.

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Microwave imaging is the technique to identify hidden objects from structures using electromagnetic waves that can be applied in medical diagnosis. The change of dielectric property can be detected using microwave antenna sensor, which can lead to localization of abnormality in the human body. This paper presents a stacked type modified Planar Inverted F Antenna (PIFA) as microwave imaging sensor. Design and performance analysis of the sensor antenna along with computational and experimental analysis to identify concealed object has been investigated in this study. The dimension of the modified PIFA radiating patch is 40 × 20 × 10 mm³. The reflector walls used, are 45 mm in length and 0.2-mm-thick inexpensive copper sheet is considered for the simulation and fabrication which addresses the problems of high expenses in conventional patch antenna. The proposed antenna sensor operates at 1.55⁻1.68 GHz where the maximum realized gain is 4.5 dB with consistent unidirectional radiation characteristics. The proposed sensor antenna is used to identify tumor in a computational human tissue phantom based on reflection and transmission coefficient. Finally, an experiment has been performed to verify the antenna's potentiality of detecting abnormality in realistic breast phantom.

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One of the most efficient methods to observe the impact of geographical, environmental, and geological changes is remote sensing. Nowadays, nanosatellites are being used to observe climate change using remote sensing technology. Communication between a remote sensing nanosatellite and Earth significantly depends upon antenna systems. Body-mounted solar panels are the main source of satellite operating power unless deployable solar panels are used. Lower ultra-high frequency (UHF) nanosatellite antenna design is a crucial challenge due to the physical size constraint and the need for solar panel integration. Moreover, nanosatellite space missions are vulnerable because of antenna and solar panel deployment complexity. This paper proposes a solar panel-integrated modified planner inverted F antenna (PIFA) to mitigate these crucial limitations. The antenna consists of a slotted rectangular radiating patch with coaxial probe feeding and a rectangular ground plane. The proposed antenna has achieved a -10 dB impedance bandwidth of 6.0 MHz (447.5 MHz⁻453.5 MHz) with a small-sized (80 mm× 90 mm× 0.5 mm) radiating element. In addition, the antenna achieved a maximum realized gain of 0.6 dB and a total efficiency of 67.45% with the nanosatellite structure and a solar panel. The challenges addressed by the proposed antenna are to ensure solar panel placement between the radiating element and the ground plane, and provide approximately 55% open space to allow solar irradiance into the solar panel.

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Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging chemotherapeutics. We show that 16:4(n-3) exerts its effect by activating splenic F4/80+/CD11blow macrophages, which results in production of chemoprotective lysophosphatidylcholines (LPCs). Pharmacologic studies, together with analysis of expression patterns, identified GPR120 on F4/80+/CD11blow macrophages as the relevant receptor for 16:4(n-3). Studies that used splenocytes from GPR120-deficient mice have confirmed this conclusion. Activation of the 16:4(n-3)-GPR120 axis led to enhanced cPLA2 activity in these splenic macrophages and secretion of the resistance-inducing lipid mediator, lysophosphatidylcholine(24:1). These studies identify a novel and unexpected function for GPR120 and suggest that antagonists of this receptor might be effective agents to limit development of chemotherapy resistance.-Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, T., Ishihara, K., Milligan, G., Voest, E. E. Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.

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A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition.

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BACKGROUND: After an era of only considering the allergenic properties of the infant diet and allergy outcomes, emerging data suggest that the overall composition of the infant diet might be a more important factor in the development of allergic disease. OBJECTIVE: We sought to assess the relationship between infant dietary patterns in the first year of life and development of food allergy by age 2 years. METHODS: We performed a nested, case-control, within-cohort study. Mothers kept prospective food diaries for the first year of life, with resultant diet data coded in a unique manner to produce new variables, which were then analyzed by using principal component analysis to identify infant feeding patterns within the study subjects. RESULTS: Principal component analysis of diet diary data from 41 infants given a diagnosis of food allergy based on results of double-blind, placebo-controlled food challenges in the first 2 years of life and their 82 age-matched control subjects provided an early infant diet pattern and an ongoing diet pattern. There was no difference between the study groups for the early infant diet pattern, but for the ongoing diet pattern, there was a significant difference between the groups (P = .001). This ongoing dietary pattern was characterized by higher intake of fruits, vegetables, and home-prepared foods, with control infants having a significantly higher healthy infant diet dietary pattern score than children who had a food allergy. CONCLUSIONS: An infant diet consisting of high levels of fruits, vegetables, and home-prepared foods is associated with less food allergy by the age of 2 years.

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For the first time, a personal distributed exposimeter (PDE) for radio frequency (RF) measurements is presented. This PDE is designed based on numerical simulations and is experimentally evaluated using textile antennas and wearable electronics. A prototype of the PDE is calibrated in an anechoic chamber. Compared to conventional exposimeters, which only measure in one position on the body, an excellent isotropy of 0.5 dB (a factor of 1.1) and a 95% confidence interval of 7 dB (a factor of 5) on power densities are measured.

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A "stop-and-flow" strategy was developed for the chemoselective dioxygenation of alkenes with a PIFA-initiated cyclization. This method is conceived for the desymmetrization of seco-diene, and a series of substituted 5-hydroxymethyl-γ-lactones were constructed after hydrolysis. This strategy also differentiates terminally substituted alkenes and constitutes a potentially novel synthetic approach for the efficient synthesis toward velbanamine.