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It is advantageous for maternally transmitted endosymbionts to skew the sex ratio of their hosts toward females. Some endosymbiotic bacteria, such as Wolbachia, cause their insect hosts to exclusively produce female offspring through male killing (MK) or feminization. In some lepidopteran insects, MK is achieved by affecting the sex-determining process in males, and a unique mechanism of MK and its functional link with feminization have been implicated. However, comparative analysis of these phenotypes is often difficult because they have been analyzed in different host-symbiont systems, and transinfection of Wolbachia across different hosts is often challenging. In this study, we demonstrated the effects of nine Wolbachia strains on the splicing of sex-determining genes in Lepidoptera by fixing the host genetic background using a cell culture system. Cell transinfection assays confirmed that three MK-inducing Wolbachia strains and one feminization-inducing Wolbachia strain increased the female-type splicing products of the core sex-determining genes doublesex, masculinizer, and zinc finger protein 2. Regarding Wolbachia strains that do not induce MK/feminization, three had no effect on these sex-determining genes, whereas two strains induced female-type splicing of masculinizer and doublesex but not zinc finger protein 2. Comparative genomics confirmed that homologs of oscar, the Wolbachia gene responsible for MK in Ostrinia, were encoded by four MK/feminizing Wolbachia strains, but not by five non-MK/nonfeminizing strains. These results support the conserved effects underlying MK and feminization induced by oscar-bearing Wolbachia and suggested other potential mechanisms that Wolbachia might employ to manipulate host sex.

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BACKGROUND: Clear cell sarcoma (CCS) and alveolar soft part sarcoma (ASPS) are rare, and standard systemic therapy is not established except for sunitinib in ASPS. It is known that CCS and ASPS have a common biological feature of melanoma and Xp11.2/TFE3 translocation renal cell carcinoma, and immune-checkpoint inhibitors (ICIs) are effective in these tumors. The authors conducted a phase 2 trial to evaluate the efficacy and safety of nivolumab for CCS and ASPS. METHODS: The number of patients expected to be enrolled was 15-25 and was determined based on the Bayesian design. The primary end point was the confirmed objective response rate (ORR) according to the central review and the secondary end points included ORR, progression-free survival (PFS), overall survival (OS), and safety. RESULTS: A total of 26 patients (CCS, 12; ASPS, 14) were enrolled. Efficacy and safety were analyzed on 25 and 26 patients, respectively. The minimum number of responses required for a positive conclusion regarding the efficacy was four. However, only one patient (4.0%) with ASPS had a partial response. Complete response, stable disease, progression disease, and not evaluable were 0%, 60%, 32%, and 4.0%, respectively. Adverse events of grade 3 or 4 occurred in 57.7% (15 of 26). The median PFS was 4.9 months (95% confidence interval [CI], 3.7-8.6 months) and the median OS was 15.8 months (95% CI, 8.2-not reached). CONCLUSIONS: The primary end point of the ORR was not met for CCS and ASPS on the central review. Further studies are needed to evaluate ICIs in patients with ASPS.

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PURPOSE: To assess the learning curve of MSICS in three different groups of trainees with varying prior MSICS experience. To evaluate the effectiveness of ICO OSCAR for objective assessment of surgical skill transfer. METHODS: Ninety-five MSICS trainees were divided into three groups as 1st year resident, fellow and external trainee. Each group were evaluated for their surgical skill acquisition during one month MSICS training program using ICO-OSCAR. Each trainee performed an average of 19 surgeries. The progress in the learning curve of the three groups of trainees was analyzed by evaluating the mean scores in sets of five consecutive cases. Complications during the training period were also noted. RESULTS: The study evaluated a total of 1842 cases. The fellows and external trainees, with prior MSICS experience, had an initial mean score of 57.57 ± 16.16 and 56.86 ± 17.82 respectively, whereas the 1st year resident group had a relatively low initial mean score of 45.91(p = 0.009). The difference in mean scores between the 1st year resident group and other groups significantly reduced towards the end of training. The most common complications made by 1st year residents were in sclero-corneal tunnel construction. The external trainee group had statistically significant higher rates of zonular dialysis in the study. CONCLUSIONS: ICO-OSCAR is an effective tool for assessing MSICS training program. Structured short term MSICS surgical training program is effective in surgical skill transfer, especially in novice surgeons.

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Wolbachia are intracellular bacteria in insects that can manipulate the sexual development and reproduction by male killing or other methods. We have recently identified a Wolbachia protein named Oscar that acts as a male-killing factor for lepidopteran insects. Oscar interacts with the Masculinizer (Masc) protein, which is required for both masculinization and dosage compensation (DC) in lepidopteran insects. Embryonic expression of Oscar inhibits masculinization and causes male killing in two lepidopteran species, Ostrinia furnacalis and Bombyx mori. However, it remains unknown whether Oscar-induced male killing is caused by a failure of DC. Here, we performed a transcriptome analysis of Oscar complementary RNA-injected O. furnacalis and B. mori embryos, and found that Oscar primarily targets the Masc protein, resulting in male killing by interfering with DC in lepidopteran insects.

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Osteoarthritis (OA) is the most common joint disease that causes local inflammation and pain, significantly reducing the quality of life and normal social activities of patients. Currently, there are no disease-modifying OA drugs (DMOADs) available, and treatment relies on pain relief agents or arthroplasty. To address this significant unmet medical need, we aimed to develop monoclonal antibodies that can block the osteoclast-associated receptor (OSCAR). Our recent study has revealed the importance of OSCAR in OA pathogenesis as a novel catabolic regulator that induces chondrocyte apoptosis and accelerates articular cartilage destruction. It was also shown that blocking OSCAR with a soluble OSCAR decoy receptor ameliorated OA in animal models. In this study, OSCAR-neutralizing monoclonal antibodies were isolated and optimized by phage display. These antibodies bind to and directly neutralize OSCAR, unlike the decoy receptor, which binds to the ubiquitously expressed collagen and may result in reduced efficacy or deleterious off-target effects. The DMOAD potential of the anti-OSCAR antibodies was assessed with in vitro cell-based assays and an in vivo OA model. The results demonstrated that the anti-OSCAR antibodies significantly reduced cartilage destruction and other OA signs, such as subchondral bone plate sclerosis and loss of hyaline cartilage. Hence, blocking OSCAR with a monoclonal antibody could be a promising treatment strategy for OA.

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Introducción: El Dr. C. Oscar B. Alonso Chil (1930-2021) formó parte de los médicos que permanecieron en Cuba después del triunfo de la Revolución. Fue fundador de servicios de asistencia en medicina interna y geriatría, y realizó importantes contribuciones a la docencia médica. Objetivo: Exponer la trayectoria de Oscar B. Alonso Chil como médico y docente de la medicina cubana revolucionaria, a través de su historia de vida. Métodos: Se realizó un estudio de tipo descriptivo y de corte cualitativo, donde se utilizó la técnica de la historia de vida, centrada en el aspecto profesional. Para ello se hizo una entrevista semiestructurada al testimoniante como fuente fundamental de información. Se validó el testimonio oral mediante la revisión de la documentación oficial en su expediente docente y la literatura científica existente relacionada con el tema, además de entrevistas a sus alumnos y compañeros de trabajo. Desarrollo: Se constató que fundó servicios; organizó la actividad docente; realizó tutorías, publicaciones y asesorías; y fue miembro de tribunales y consejos científicos. Cada una de sus actividades las desempeñó con gran compromiso e incondicionalidad a su profesión, lo cual le generó mucha satisfacción con la vida. Llegó a ostentar las más altas distinciones por su trabajo: Especialista de Segundo Grado en Medicina Interna, y Profesor Titular, Consultante y de Mérito de la Universidad de Ciencias Médicas de La Habana. Conclusiones: Oscar B. Alonso Chil contribuyó al desarrollo de la medina interna en Cuba en la etapa revolucionaria. Este profesor representa un modelo para los estudiantes de ciencias médicas por su prestigio profesional y científico(AU)

Introduction: Ph.D. Oscar B. Alonso Chil (b. 1930-d. 2021) was one of the physicians who stayed in Cuba after the triumph of the Revolution. He was a founder of the healthcare services for internal medicine and geriatrics, and made important contributions to medical teaching. Objective: To present the professional career of Oscar B. Alonso Chil as a physician and teacher of revolutionary Cuban medicine, through his life history. Methods: A descriptive and qualitative study was carried out, using the life history technique, focused on the professional aspect. For this purpose, a semistructured interview was conducted with the testimony witness as a fundamental source of information. The oral testimony was validated by reviewing the official documentation in his teaching file and the existing scientific literature related to the subject; in addition to interviews with his students and coworkers. Development: It was observed that he founded services, organized the teaching activity, supervised research, made publications and consultancies, and was a member of scientific boards and councils. He performed each of these activities with great commitment and unconditionality to his profession, which gave him great satisfaction with life. He achieved holding the highest distinctions for his work: second-degree specialist in Internal Medicine, as well as Full Professor, Faculty Consultant and Emeritus Professor of the University of Medical Sciences of Havana. Conclusions: Oscar B. Alonso Chil contributed to the development of internal medicine in Cuba during the revolutionary period. This professor represents a role model for students of medical sciences due to his professional and scientific prestige(AU)

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The Arctic ecozone is undergoing a rapid transformation in response to climate change. Establishing a baseline of current Arctic biodiversity is necessary to be able to track changes in species diversity and distribution over time. Here, we report a vascular plant floristic study of Katannilik Territorial Park, Kimmirut and vicinity within Circumpolar Arctic Bioclimate Subzone D on southern Baffin Island, Nunavut, Canada. We compiled a dataset of 1596 collections gathered in the study area throughout the last century, including 838 we made in 2012. The vascular flora comprises 35 families, 98 genera, 211 species, two nothospecies and seven infraspecific taxa. We newly recorded 51 taxa in 22 families in the study area: Erigeroneriocephalus, Taraxacumholmenianum (Asteraceae), Drabaarctica, D.fladnizensis, D.lactea (Brassicaceae), Campanularotundifolia (Campanulaceae), Arenarialongipedunculata, Honckenyapeploidessubsp.diffusa, Sabulinarossii, Sileneuralensissubsp.uralensis, Viscariaalpina (Caryophyllaceae), Carexbrunnescenssubsp.brunnescens, C.krausei, C.microglochin, C.subspathacea, C.williamsii, Eriophorumscheuchzerisubsp.arcticum (Cyperaceae), Andromedapolifolia, Orthiliasecundasubsp.obtusata (Ericaceae), Oxytropispodocarpa (Fabaceae), Luzulagroenlandica (Juncaceae), Triglochinpalustris (Juncaginaceae), Utriculariaochroleuca (Lentibulariaceae), Huperziacontinentalis (Lycopodiaceae), Montiafontana (Montiaceae), Corallorhizatrifida, Platantheraobtusatasubsp.obtusata (Orchidaceae), Hippurislanceolata, H.vulgaris, Plantagomaritima (Plantaginaceae), Calamagrostisneglectasubsp.groenlandica, C.purpurascens, Festucaproliferavar.lasiolepis, F.rubrasubsp.rubra, F.rubrasubsp.arctica, Hordeumjubatumsubsp.jubatum, Leymusmollissubsp.mollis, L.mollissubsp.villosissimus, Puccinelliavaginata (Poaceae), Primulaegaliksensis (Primulaceae), Cryptogrammastelleri (Pteridaceae), Coptidium×spitsbergense (Ranunculaceae), Potentillacrantzii, P.hyparcticasubsp.hyparctica, Rubuschamaemorus, Sibbaldiaprocumbens (Rosaceae), Salixfuscescens (Salicaceae), Micranthesfoliolosa, M.nivalis, M.tenuis (Saxifragaceae) and Woodsiaalpina (Woodsiaceae). We recorded 196 taxa in Katannilik Territorial Park (191 species, three infraspecific taxa and two nothospecies); 145 of these taxa are first records for the park. We recorded 170 taxa in Kimmirut and vicinity (166 species, three infraspecific taxa and one nothospecies) in Kimmirut and vicinity; 15 of these taxa are first records for Kimmirut and vicinity. All study area species are native, except two grasses that grew in Kimmirut: F.rubrasubsp.rubra, which may have been seeded and Hordeumjubatumsubsp.jubatum, of unknown origin. We summarize the distribution on Baffin Island for each taxon recorded in the study area, including several unpublished southern Baffin Island records.

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PURPOSE: To develop an internationally standardized and validated tool to assess skill in performing tube shunt surgery. DESIGN: A panel of 6 glaucoma surgeons developed a tool for assessing tube shunt surgery using a modified Dreyfus scale for skill acquisition. The tool was reviewed by a panel of 10 international content experts, and their comments were incorporated into the final rubric. PARTICIPANTS: A different panel of 8 international glaucoma specialists independently graded videos of surgical procedures performed by 6 surgeons at various levels of ophthalmic training. MAIN OUTCOME MEASURES: Inter-rater reliability for each step in the rubric was calculated. RESULTS: The tube shunt rubric contained 13 steps specific to tube shunt surgery and 7 global indices. The Cronbach α statistic, a measure of internal reliability, ranged from 0.75 to 0.97, indicating strong internal reliability for all 13 steps. CONCLUSIONS: The tube shunt assessment tool has face validity, content validity, and interobserver reliability, and can be used to assess tube shunt surgery skills. Further studies are required to determine predictive and construct validity.

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Osteoclastogenesis, one of the dynamic pathways underlying bone remodelling, is a complex process that includes many stages. This complexity, while offering a wealth of therapeutic opportunities, represents a substantial challenge in unravelling the underlying mechanisms. As such, there is a high demand for robust model systems to understand osteoclastogenesis. Hydrogels seeded with osteoclast precursors and decorated with peptides or proteins mimicking bone's extracellular matrix could provide a useful synthetic tool to study pre-osteoclast-matrix interactions and their effect on osteoclastogenesis. For instance, fibrillar collagens have been shown to provide a co-stimulatory pathway for osteoclastogenesis through interaction with the osteoclast-associated receptor (OSCAR), a regulator of osteoclastogenesis expressed on the surface of pre-osteoclast cells. Based on this rationale, here we design two OSCAR-binding peptides and one recombinant OSCAR-binding protein, and we combine them with peptide-based hydrogels to study their effect on osteoclastogenesis. The OSCAR-binding peptides adopt the collagen triple-helical conformation and interact with OSCAR, as shown by circular dichroism spectropolarimetry and surface plasmon resonance. Furthermore, they have a positive effect on osteoclastogenesis, as demonstrated by appropriate gene expression and tartrate-resistant acid phosphatase staining typical of osteoclast formation. Combination of the OSCAR-binding peptides or the OSCAR-binding recombinant protein with peptide-based hydrogels enhances osteoclast differentiation when compared to the non-modified hydrogels, as demonstrated by multi-nucleation and by F-actin staining showing a characteristic osteoclast-like morphology. We envisage that these hydrogels could be used as a platform to study osteoclastogenesis and, in particular, to investigate the effect of costimulatory pathways involving OSCAR.

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Osteoclast-associated receptor (OSCAR) is a member of the leukocyte receptor complex (LRC)-encoded protein family, which is characterized by the presence of immunoglobulin (Ig)-like domains. OSCAR recognizes collagen and was first identified as a co-stimulatory receptor that is needed for complete osteoclast differentiation. However, it is now clear that OSCAR is also expressed by multiple immune cells that participate in many innate and adaptive immune cell activities. We also showed recently that chondrocytes express OSCAR. Our and other studies suggest that OSCAR participates in the pathogenesis of two common joint diseases, namely, rheumatoid arthritis (RA) and osteoarthritis (OA). Specifically, OSCAR promotes osteoclast formation and therefore bone erosion in RA while in OA, it triggers chondrocyte death, thereby inducing cartilage fragility. Significantly, blocking the interaction of OSCAR with its collagen ligand can markedly reduce these activities in vitro and in vivo. Thus, this novel approach may have therapeutic potential for joint diseases.

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Despite the closet's centrality to queer culture and theory, the metaphor's various meanings have yet to be disaggregated and defined. Following Eve Kosofsky Sedgwick's identification of the closet with a "crisis of homo/heterosexual definition, indicatively male, dating from the end of the nineteenth century," the present article uses an array of late-Victorian sources-especially The Memoirs of John Addington Symonds and Teleny, a pornographic novel sometimes attributed to Oscar Wilde-to describe and distinguish: (1) so-called latent homosexuality ("the unconscious closet"); (2) deliberate strategies of suppression, abstention, and reformation ("the conscious closet"); (3) clandestine pursuits of gay sex and sociability ("the double life"); and (4) performances of a heterosexual persona ("the mask"). This article's sources further attest to the late-Victorian advent of "closet consciousness"-a recognition among certain homosexually-inclined men that the closet's multiple modalities, for all their variety, are phenomenologically and ideologically linked.

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Este artigo apresenta resultados de uma pesquisa que investigou a produção de memórias e esquecimentos relacionada ao extinto "Abrigo Municipal de Alienados Oscar Schneider", instituição que funcionou em Joinville/SC entre 1923 e 1942 e teve seu prédio demolido cerca de 50 anos depois da sua construção. A inauguração da instituição marcou o início do projeto de "modernização-urbanização" de Joinville, pautado em normas higiênicas centradas nas novas prerrogativas da ciência moderna. Para a realização da pesquisa, rastreamos documentos que contam a história do Abrigo de Alienados: encontramos fotografias, um cartão-postal, trechos de documentos oficiais e notícias de jornal. Com esses documentos, problematizamos o campo de produção da fama e da infâmia em relação a determinados personagens que compuseram a cena dos acontecimentos dessa instituição. O olhar para os registros do Abrigo de Alienados procurou tensionar as diversas vozes que ali se encontram para seguir os rastros insignificantes de uma história, os quais correspondem a certos fatos e sujeitos que não foram considerados dignos de serem memorados: as vidas que sofreram a experiência do confinamento no Abrigo. (AU)

This article presents results of a research that investigated memories and forgetfulness production related to the already extinct "Abrigo Municipal de Alienados Oscar Schneider", an institution that operated in Joinville, state of Santa Catarina, between 1923 and 1942, whose building was destroyed 50 years after its construction. The institution inauguration marked the beginning of Joinville's "modernization-urbanization" project, based on hygienic standards centered on the new prerogatives of modern science. To conduct this research, we traced documents that narrates the Alienated People's Shelter history: we found photographs, a postcard, oficial documents excerpts, and newspaper news. With these documents, we problematized fame and infamy production field in relation to some characters that were part of the institution happenings scene. Our vision to the Alienated People's Shelter aimed to tense up several voices that exist there to follow the insignificant trails of a history which corresponds to certain facts and subjects not considered dignified to be remembered: the suffering lives of the Shelter confinement experience. (AU)

Este artículo presenta los resultados de una investigación que examinó la producción de recuerdos y olvidos relacionados con el extinto Abrigo Municipal de Alienados Oscar Schneider, institución que funcionó en Joinville/SC entre 1923 y 1942 y cuyo edificio fue demolido unos 50 años después de su construcción. La inauguración de la institución marcó el inicio del proyecto de "modernización-urbanización" de Joinville, basado en estándares higiénicos centrados en las nuevas prerrogativas de la ciencia moderna. Para llevar a cabo la investigación, rastreamos documentos que cuentan la historia del Abrigo de Alienados: encontramos fotografías, una tarjeta postal, extractos de documentos oficiales y noticias de periódicos. Con estos documentos, problematizamos el campo de producción de fama e infamia en relación con ciertos personajes que componían la escena de los acontecimientos de esa institución. La mirada a los registros del Abrigo de Alienados trató de problematizar las diversas voces presentes para seguir los rastros insignificantes de una historia, los cuales corresponden a ciertos hechos y sujetos que no fueron considerados dignos de ser memorizados: las vidas que sufrieron la experiencia de confinamiento en el Abrigo. (AU)

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Resumo O artigo analisa o curso Educação Sanitária (Higiene e Medicina Preventiva), idealizado pelo médico-chefe do Serviço de Inspeção Médica e da Assistência Dentária Escolar, Oscar Clark, em 1929. Problematiza a concepção de formação de professor que se instituiu a fim de produzir uma "cruzada saneadora" pelas escolas da capital federal. Parte-se da compreensão de que o curso se configurou em lócus a partir do qual se enunciaram lições de caráter educativo-higiênico, funcionando como espaço de prescrição médica, pedagógica e científica. A concepção que orienta a análise é a de que o curso fez parte das estratégias da Diretoria de Instrução (1927-1930), visando estabelecer um ethos normativo e educativo às práticas ordinárias das professoras.

Abstract This article analyzes the course in health education (Hygiene and Preventive Medicine) developed in 1929 by Oscar Clark, head doctor of the Medical Inspection and School Dental Care Service. We investigate the concept of teacher training implemented in schools in Rio de Janeiro (then Brazil's capital) to create a "health crusade." We start from the understanding that the course emerged in locus and produced lessons on education and hygiene, acting as a prescriptive space for medicine, pedagogy, and science, remembering that the course was part of the strategies of the Board of Instruction (1927-1930) to establish a normative and educational ethos for everyday teaching practices.

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Cross talk between tumors and the immune microenvironment play a critical role in the malignant progression. The osteoclast-associated receptor (OSCAR) is a regulator of lymphocyte differentiation and maturation, but little is known about the role of OSCAR in multiple cancer types. We comprehensively analyzed OSCAR expression and explored its correlation with prognosis in multiple cancer types using Oncomine, TIMER, Gene GEPIA2 and CCLE. We examined OSCAR expression correlations with lymph node metastasis and pathological stage across tumor samples using UALCAN and GEPIA2. We analyzed the effects of OSCAR on survival using the Kaplan Meier plotter. We explored genes co-expressed with OSCAR using the LinkedOmics database and analyzed associated gene ontologies using Metascape. Further, we examined the correlation between OSCAR expression and immunocyte infiltration, markers of epithelial-mesenchymal transition, and lymphocyte subtypes using TIMER. OSCAR mRNA levels were upregulated in most cancer types compared with adjacent normal tissues. Higher expression of OSCAR correlated with lymph node metastasis or advanced stage subgroups. High expression of OSCAR was related to low tumor purity, with increased levels of M2 macrophage polarization, T cells exhaustion, and mesenchymal phenotype in most cancer types. We also showed that the strength of OSCAR expression influence in malignant progression and inhibitory immune microenvironment is mitigated by the infiltration of natural killer cells. These findings shed light on the pro-carcinogenic role of OSCAR in most cancer types and indicate OSCAR could be targeted in future therapeutics to reverse the inhibitory immune microenvironment.

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Abstract Oscar Nerval de Gouvêa was a scientist and teacher in Rio de Janeiro, Brazil, whose work spanned engineering, medicine, the social sciences, and law. This paper presents and discusses a manuscript entitled "Table of mineral classification," which he appended to his dissertation Da receptividade mórbida , presented to the Faculty of Medicine in 1889. The foundations and features of the table provide a focus for understanding nineteenth-century mineralogy and its connections in Brazil at that time through this scientist. This text was Gouvêa's contribution to the various mineral classification systems which have emerged from different parts of the world.

Resumo Oscar Nerval de Gouvêa foi um cientista e professor no Rio de Janeiro, Brasil, cuja obra abrange engenharia, medicina, ciências sociais e direito. Este artigo apresenta e discute o texto intitulado "Tabela de classificação mineral", que ele anexou a sua tese Da receptividade mórbida, apresentada na Escola Superior de Medicina, em 1889. Os fundamentos e características da tabela propiciam a compreensão da mineralogia do século XIX e suas conexões no Brasil à época por intermédio desse cientista. O texto foi a contribuição de Gouvêa aos diversos sistemas de classificação de minerais originados de diferentes partes do mundo.

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Formation of mature bone-resorbing cells through osteoclastogenesis is required for the continuous remodeling and repair of bone tissue. In aging and disease this process may become aberrant, resulting in excessive bone degradation and fragility fractures. Interaction of receptor-activator of nuclear factor-κB (RANK) with its ligand RANKL activates the main signaling pathway for osteoclastogenesis. However, compelling evidence indicates that this pathway may not be sufficient for the production of mature osteoclast cells and that co-stimulatory signals may be required for both the expression of osteoclast-specific genes and the activation of osteoclasts. Osteoclast-associated receptor (OSCAR), a regulator of osteoclast differentiation, provides one such co-stimulatory pathway. This review summarizes our present knowledge of osteoclastogenesis signaling and the role of OSCAR in the normal production of bone-resorbing cells and in bone disease. Understanding the signaling mechanism through this receptor and how it contributes to the production of mature osteoclasts may offer a more specific and targeted approach for pharmacological intervention against pathological bone resorption.

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(1) Background: Intravitreal injections (IVIs) are the most commonly performed intraocular procedure worldwide. Ensuring correct learning is essential to avoid complications. Our purpose was to develop an internationally valid tool to assess skill in performing IVIs. (2) Methods: A panel of six content experts designed a rubric for assessing the IVI procedure by using a modified Dreyfus scale of skill acquisition, dividing it into steps and providing objective behavioral descriptors for each level of skill in each category, following the International Council of Ophthalmology (ICO) guidance. The rubric draft was then critically reviewed by 12 international content experts, and their constructive comments were considered for the final rubric. (3) Results: The Ophthalmology Surgical Competency Assessment Rubric for IVI (ICO-OSCAR:IVI) is the proposed tool for assessing healthcare professionals training to perform IVI. (4) Conclusions: The ICO-OSCAR:IVI is the result of the consensus of an international expert panel. The methodology used for its development provides this rubric with face and content validity. It can be used globally to assess healthcare professionals training to perform IVI, as well as the impact of different teaching methods on performance. Further studies are required to establish intra- and inter-rater reliability, as well as the predictive validity of this tool.

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O artigo analisa o curso EducaçãoSanitária (Higiene e MedicinaPreventiva), idealizado pelo médicochefe do Serviço de Inspeção Médica e daAssistência Dentária Escolar, Oscar Clark,em 1929. Problematiza a concepção deformação de professor que se instituiua fim de produzir uma “cruzadasaneadora” pelas escolas da capitalfederal. Parte-se da compreensão de queo curso se configurou em lócus a partirdo qual se enunciaram lições de carátereducativo-higiênico, funcionando comoespaço de prescrição médica, pedagógicae científica. A concepção que orienta aanálise é a de que o curso fez parte dasestratégias da Diretoria de Instrução(1927-1930), visando estabelecer umethos normativo e educativo às práticasordinárias das professoras

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