RESUMEN

Introducción:El cáncer representa un extraordinario problema para la Salud Pública mundial, suponiendo la primera causa de mortalidad global. El cáncer de pulmón es el más frecuente. El número de defunciones se ha ordenado de acuerdo a la Clasificación de Bertillon. El objetivo del estudio fue analizar las causas de mortalidad por cáncer; determinar que grupos de edad presentan más muertes y que estaciones; calcular las tasas de mortalidad.Materiales y métodos:mediante la lectura de los Libros de Defunción del Archivo Parroquial de la ciudad (APJC), se han obtenido 26.203 difuntos, 18.538 de los cuales tienen anotado el motivo de su muerte, los cuales son utilizados para su análisis posterior.Resultados:Se registraron 182 defuncionespor cáncer(1% del total), la gran mayoría adultos, 165 (90.7%), siendo las mujeres casi el doble, 121 (66.5%). La mayor mortalidad se da entre los 45 y los 74 años, 122 difuntos (67.0%). El cáncer más frecuente es el del apartado de otros órganos, con 50 defunciones (40.6%). El mes con más muertos es marzo.las papeletas de defunción solían presentar errores ortográficos o de transcripción. Estudios similares en otras poblaciones arrojan cifras dispares según el periodo analizado y la cifra de muertos. Existe una estrecha relación entre cáncer y edad.Conclusión:El cáncer de otros órganos es el más numeroso. La mortalidad difiere entre las distintas poblaciones comparadas. El número de difuntos es muy inferior al actual, debido a la falta de medios diagnósticos y conocimientos de la época y la posible existencia de un subregistro

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Introduction: Cancer represents an extraordinary problem for Global Public Health and is the leading cause of global mortality. Lung cancer is the most common cancer. The number of deaths was ordered according to the Bertillon Classification. The objective of the study was to analyze the causes of mortality due to cancer, determine which age groups have the most deaths and which seasons, and calculate mortality rates.Materials and methods: By reading the Death Books of the city's Parish Archive (APJC), 26,203 deceased persons were obtained, 18,538 of whom were diagnosed with COVID-19, and these individuals were used for subsequent analysis.Results: A total of 182deaths due to cancer were recorded (1% of the total);the vast majority wereadults (165,90.7%), with nearlytwice as manywomen (121, 66.5%). The highest mortal-ity occurredbetween 45 and 74 years of age, with 122 deaths (67.0%). The most common cancer wasthat of other organs, accounting for50 deaths (40.6%). The month with the most deaths wasMarch. Death certificates often had spelling or transcription errors. Similar studies in other populations show different figures depending on the period analyzed and the number of deaths. There is a close relationship between cancer incidence and age.Conclusion: Cancer of other organs is the most common cancer. Mortality differs between the different populations compared. The number of deaths is much lower than the current numberdue to the lack of diagnostic methods, knowledge of the time,and the possibility of underrecording

Asunto(s)

Humanos , Masculino , Femenino , Adulto , Anciano , Neoplasias Pulmonares , Neoplasias

RESUMEN

Abstract A 71 year-old male with a history of multiple excisions of an initial Clark's level V melanoma of the breast followed by combined radiation and interferon treatment, as well as a recurrence, 3 years later, of a BRAF-positive tumor of the shoulder, with subsequent therapy with dabrafenib and trametinib, presented again with progressive intracardiac masses causing significant right ventricular outflow obstruction. Additionally, the patient complained of dyspnea and fatigue on exertion, thus he was scheduled for surgical resection.

Asunto(s)

Humanos , Masculino , Anciano , Neoplasias Cutáneas/cirugía , Neoplasias Cardíacas/cirugía , Neoplasias Cardíacas/diagnóstico por imagen , Melanoma/cirugía , Melanoma/tratamiento farmacológico , Mutación , Recurrencia Local de Neoplasia

RESUMEN

A 71 year-old male with a history of multiple excisions of an initial Clark's level V melanoma of the breast followed by combined radiation and interferon treatment, as well as a recurrence, 3 years later, of a BRAF-positive tumor of the shoulder, with subsequent therapy with dabrafenib and trametinib, presented again with progressive intracardiac masses causing significant right ventricular outflow obstruction. Additionally, the patient complained of dyspnea and fatigue on exertion, thus he was scheduled for surgical resection.

Asunto(s)

Neoplasias Cardíacas , Melanoma , Neoplasias Cutáneas , Anciano , Neoplasias Cardíacas/diagnóstico por imagen , Neoplasias Cardíacas/cirugía , Humanos , Masculino , Melanoma/tratamiento farmacológico , Melanoma/cirugía , Mutación , Recurrencia Local de Neoplasia , Neoplasias Cutáneas/cirugía

RESUMEN

Radiation therapy on the left side of the chest, some chemotherapy drugs, and trastuzumab raise the risk of cardiac events. Acute chest pain associated with breast cancer is not common, but it is possible. Electrocardiogram, which can result normal in up to 80% of cases of infarction, and serial dosing of myocardial necrosis markers are fundamental for differential diagnosis. Total creatine kinase (CK), creatine kinase-MB fraction (CK-MB), and troponins are frequently used. We present the case of a patient with atypical chest pain associated with elevation of CK and CK-MB, whose evolution and complementary exams showed to be a thoracic tumor recurrence. We discuss the use of these markers for acute chest pain; possible differential diagnoses, the use of CKMB relative index and, particularly, the presence of macro CK in some breast cancer patients ­ which in the case herein presented was a marker of tumor progression.

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A radioterapia do lado esquerdo do tórax, alguns quimioterápicos e o trastuzumabe elevam o risco de eventos cardíacos. A dor torácica aguda associada ao câncer de mama não é um evento frequente, mas é possível. No diagnóstico diferencial, faz-se necessário o eletrocardiograma, que pode ser normal em até 80% dos infartos, e a dosagem seriada de marcadores de necrose miocárdica, sendo frequentemente utilizados a creatinoquinase (CK) total, a creatinnoquinase fração MB (CK-MB) e as troponinas. Apresentamos o caso de uma paciente com dor torácica atípica associada à elevação sérica da CK e da CK-MB, sendo que a evolução e os exames complementares mostraram tratar-se de uma recorrência tumoral torácica. Discutem-se a utilização desses marcadores na dor torácica aguda, os diagnósticos diferenciais possíveis, a utilização do índice relativo CK-MB e, em especial, as macro CK presentes em algumas portadoras de câncer de mama, o que, nessa paciente, foi um marcador de progressão tumoral.