1.
Bioorg Med Chem
; 24(5): 1014-22, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26819000
RESUMEN
Amino derivatives of NCI8642 were synthesized and evaluated as inhibitors of DKK1/LRP6 interactions. The new inhibitors were able to activate the Wnt signaling pathway as indicated by the increased levels of ß-catenin, and decrease the DKK1-induced Tau phosphorylation at serine 396.