RESUMEN

To evaluate the antioxidant activity of potential synthetic enzyme mimetics, we prepared new five copper(II) complexes via a self-assembly method and named them [Cu(2-(HOCH2)py)3](ClO4)2 (1), [Cu(2-(HOCH2)py)2(H2O)2]SiF6 (2), [Cu2(2-(HOCH2CH2)py)2(2-(OCH2CH2)py)2](ClO4)2 (3), [Cu(pyBIm)3](BF4)2·1.5H2O (4) and [Cu(py2C(OH)2)2](ClO4)2 (5). The synthetic protocol involved N,O- or N,N-donors: 2-(hydroxymethyl)pyridine (2-(HOCH2)py), 2-(hydroxyethyl)pyridine (2-(HOCH2CH2)py), 2-(2-pyridyl)benzimidazole (pyBIm), di(2-pyridyl)ketone (py2CO). The obtained Cu(II) complexes were fully characterised by elemental analysis, FTIR, EPR, UV-Vis, single-crystal X-ray diffraction and Hirshfeld surface analysis. Crystallographic and spectroscopic analyses confirmed chromophores of both monomeric ({CuN3O3} (1), {CuN2O4} (2), {CuN6} (4), {CuN4O2} (5)) and dimeric complex ({CuN2O3} (3)). Most of the obtained species possessed a distorted octahedral environment, except dimer 3, which consisted of two copper centres with square pyramidal geometries. The water-soluble compounds (1, 3 and 5) were selected for biological testing. The results of the study revealed that complex 1 in solutions displayed better radical scavenging activity than complexes 3, 5 and free ligands. Therefore, complex 1 has been selected for further studies to test its activity as an enzyme mimetic. The chosen compound was tested on the erythrocyte lysate of two groups of patients after undergoing chemotherapy and chemoradiotherapy. The effect of the tested compound (1) on enzyme activity levels (TAS, SOD and CAT) suggests that the selected complex can be treated as a functional mimetic of the enzymes.

Asunto(s)

RESUMEN

The synthesis, isolation and crystal structures of nickel(II) carbonyl, aceto-nitrile and ammonia complexes supported by a dianionic, pyridine dipyrrolide pincer ligand [pyrr2py]2-, namely, carbonyl[2,2'-(pyridine-2,6-di-yl)bis-(3,5-di-p-tolyl-pyrrolido-κN)]-nickel(II), [Ni(C41H33N3)(CO)], ammine[2,2'-(pyridine-2,6-di-yl)bis-(3,5-di-p-tolyl-pyrrolido-κN)]nickel(II), [Ni(C41H33N3)(NH3)], and (aceto-nitrile-κN)[2,2'-(pyridine-2,6-di-yl)bis-(3,5-di-p-tolyl-pyrrolido-κN)]nickel(II), [Ni(C41H33N3)(CH3CN)], as well as the free ligand 2,6-bis-(3,5-di-p-tolyl-pyrrol-2-yl)pyridine, C41H35N3 or [pyrr2py]H2 are reported. The nickel complexes are four-coordinate and adopt a square-planar geometry. The CO stretch of the nickel-bound carbon monoxide ligand of [pyrr2py]Ni(CO) has been observed at 2101 cm-1. The ammonia and aceto-nitrile complexes, [pyrr2py]Ni(NH3) and [pyrr2py]Ni(NCMe) feature all-nitro-gen coordination spheres around nickel consisting of different N-donor ligand types.

RESUMEN

A new class of neutral bis-tridentate Ir(III) metal complexes that show nearly unitary red, green, and blue emissions in solution is prepared and employed for the fabrication of both monochrome and white-emitting organic light-emitting diodes, among which a green device gives external quantum efficiency exceeding 31%.

RESUMEN

In the title mol-ecular salt, C10H15ClNS(+)·Cl(-), the cation is [R'R"NH2](+), where R' is 2-MeS-C6H4CH2- and R" is -CH2CH2Cl, and the anion is Cl(-). In the cation, the N atom is protonated with sp (3)-hybridization and with a tetra-hedral geometry. In the crystal, the anions are connected to the cations through two pairs of N-H⋯Cl hydrogen bonds, generating a four-centred inversion dimer with an R 4 (2)(8) ring motif.