RESUMEN
BACKGROUND: Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying intensity levels. Electroencephalography (EEG), as a crucial technology for monitoring and predicting epileptic seizures, plays an essential role in improving the quality of life for people with epilepsy. METHOD: This study introduces an innovative deep learning model, a lightweight triscale yielding convolutional neural network" (LTY-CNN), that is specifically designed for EEG signal analysis. The model integrates a parallel convolutional structure with a multihead attention mechanism to capture complex EEG signal features across multiple scales and enhance the efficiency achieved when processing time series data. The lightweight design of the LTY-CNN enables it to maintain high performance in environments with limited computational resources while preserving the interpretability and maintainability of the model. RESULTS: In tests conducted on the SWEC-ETHZ and CHB-MIT datasets, the LTY-CNN demonstrated outstanding performance. On the SWEC-ETHZ dataset, the LTY-CNN achieved an accuracy of 99.9%, an area under the receiver operating characteristic curve (AUROC) of 0.99, a sensitivity of 99.9%, and a specificity of 98.8%. Furthermore, on the CHB-MIT dataset, it recorded an accuracy of 99%, an AUROC of 0.932, a sensitivity of 99.1%, and a specificity of 93.2%. These results signify the remarkable ability of the LTY-CNN to distinguish between epileptic seizures and nonseizure events. Compared to other existing epilepsy detection classifiers, the LTY-CNN attained higher accuracy and sensitivity. CONCLUSION: The high accuracy and sensitivity of the LTY-CNN model demonstrate its significant potential for epilepsy management, particularly in terms of predicting and mitigating epileptic seizures. Its value in personalized treatments and widespread clinical applications reflects the broad prospects of deep learning in the health care sector. This also highlights the crucial role of technological innovation in enhancing the quality of life experienced by patients.
Asunto(s)
Epilepsia , Calidad de Vida , Humanos , Convulsiones/diagnóstico , Epilepsia/diagnóstico , Redes Neurales de la Computación , Electroencefalografía/métodos , Tecnología , AlgoritmosRESUMEN
BACKGROUND: Many biological studies have shown that lncRNAs regulate the expression of epigenetically related genes. The study of lncRNAs has helped to deepen our understanding of the pathogenesis of complex diseases at the molecular level. Due to the large number of lncRNAs and the complex and time-consuming nature of biological experiments, applying computer techniques to predict potential lncRNA-disease associations is very effective. To explore information between complex network structures, existing methods rely mainly on lncRNA and disease information. Metapaths have been applied to network models as an effective method for exploring information in heterogeneous graphs. However, existing methods are dominated by lncRNAs or disease nodes and tend to ignore the paths provided by intermediate nodes. METHODS: We propose a deep learning model based on hierarchical graphical attention networks to predict unknown lncRNA-disease associations using multiple types of metapaths to extract features. We have named this model the MMHGAN. First, the model constructs a lncRNA-disease-miRNA heterogeneous graph based on known associations and two homogeneous graphs of lncRNAs and diseases. Second, for homogeneous graphs, the features of neighboring nodes are aggregated using a multihead attention mechanism. Third, for the heterogeneous graph, metapaths of different intermediate nodes are selected to construct subgraphs, and the importance of different types of metapaths is calculated and aggregated to obtain the final embedded features. Finally, the features are reconstructed using a fully connected layer to obtain the prediction results. RESULTS: We used a fivefold cross-validation method and obtained an average AUC value of 96.07% and an average AUPR value of 93.23%. Additionally, ablation experiments demonstrated the role of homogeneous graphs and different intermediate node path weights. In addition, we studied lung cancer, esophageal carcinoma, and breast cancer. Among the 15 lncRNAs associated with these diseases, 15, 12, and 14 lncRNAs were validated by the lncRNA Disease Database and the Lnc2Cancer Database, respectively. CONCLUSION: We compared the MMHGAN model with six existing models with better performance, and the case study demonstrated that the model was effective in predicting the correlation between potential lncRNAs and diseases.
Asunto(s)
Neoplasias de la Mama , Neoplasias Pulmonares , MicroARNs , ARN Largo no Codificante , Humanos , Femenino , ARN Largo no Codificante/genética , Biología Computacional/métodos , MicroARNs/genética , AlgoritmosRESUMEN
The establishment of specific targets for the global carbon peaking and neutrality raises urgent requirements for prediction of CO2 emission performance indexes (CEPIs) and industrial structure optimization. However, accurate multi-objective prediction of CEPIs is still a knotty problem. In the present study, multihead attention-based convolutional neural network (MHA-CNN) model was proposed for accurate prediction of 4 CEPIs and further provided the rational suggestions for further industrial structure optimization. The proposed MHA-CNN model introduces deep learning mechanism with efficient resolution strategies for training model overfitting, feature extraction, and self-supervised learning to acquire the adaptability for CEPIs. Multihead attention (MHA) mechanism plays important roles in influence weight interpretation of variables to facilitate the prediction performance of CNN on CEPIs. The MHA-CNN model presented its overwhelmingly superior performance to CNN model and long short-term memory (LSTM) model, two frequently-used models, in multi-objective prediction of CEPIs using 8 influence variables, which highlighted advantages of MHA module in multi-dimensional feature extraction. Additionally, contributions of influence variables to CEPIs based on MHA analyses presented relatively high consistency with the geographical distribution analyses, indicating the excellent capacity of the MHA module in variable weights identification and contribution dissection. Based on the more accurate prediction results by MHA-CNN than those by CNN and LSTM model, the increase in the tertiary industry and the decreases in the first and secondary industries are conducive to improvement of total-factor carbon emission efficiency and further enhancement of effective energy utilization in regions with inefficient carbon emissions. This study provides insights towards the critical roles of the proposed MHA-CNN model in accurate multi-objective prediction of CEPIs and further industrial structure optimization for improvement of total-factor carbon emission efficiency.
Asunto(s)
Dióxido de Carbono , Carbono , Industrias , Redes Neurales de la Computación , Proyectos de InvestigaciónRESUMEN
Imidacloprid (IMI), as the most widely used neonicotinoid insecticide, poses a serious threat to the water ecosystem due to the inefficient elimination in the traditional water treatment. Chitosan (CTS)-stabilized biochar (BC)-supported Ag nanoparticles (CTS@AgBC) are applied to eliminate the IMI in the water treatment effectively. Batch experiments depict that the modification of BC by CTS and Ag nanoparticles remarkably improve its adsorption performance. The pseudo-second-order and Elovich models have good performance in simulating the adsorption processes of CTS@AgBC and BC. This indicates that the chemical adsorption on real surfaces plays the dominant role in the adsorption of IMI by CTS@AgBC and BC. In addition, the multihead attention (MHA)-based convolutional neural network (CNN) combined with the time-dependent Cox regression model are initially applied to predict and dissect the adsorption elimination processes of IMI by CTS@AgBC. The proposed MHA-CNN model achieves more accurate concentration prediction of IMI than traditional models. According to influence weights by MHA module, biochar category, pH, and treatment temperature are considered the three dominant environmental variables to determine the IMI elimination processes. This study provides insights into roles of environmental variables in the elimination of IMI by CTS@AgBC and the accurate prediction of IMI concentration.