Asunto(s)
Enfermedad de Castleman/diagnóstico , Infecciones por VIH/complicaciones , Herpesvirus Humano 8/aislamiento & purificación , Ganglios Linfáticos/patología , Sarcoma de Kaposi/complicaciones , Sarcoma de Kaposi/patología , Adulto , Fármacos Anti-VIH/uso terapéutico , Antineoplásicos/uso terapéutico , Terapia Antirretroviral Altamente Activa , Biopsia , Enfermedad de Castleman/complicaciones , Enfermedad de Castleman/tratamiento farmacológico , Femenino , Humanos , Ganglios Linfáticos/virología , Masculino , Estudios Retrospectivos , Sarcoma de Kaposi/virología , Coloración y EtiquetadoRESUMEN
Multicentric Castleman's disease (MCD) is a known entity with characteristics of lymphoproliferative syndrome, characterized by cytokine activation. Its association with human immunodeficiency virus (HIV) is frequently described, as well as its positivity for human herpesvirus 8 (HHV-8). However, some negative patients for the latter (called idiopathic MCD), may have an aggressive spectrum of the disease (characterized by the presence of cytopenia, renal failure, anasarca and organomegaly), known as TAFRO syndrome (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly). We present the case of a young patient recently diagnosed with HIV infection, in whom MCD was found, and with an aggressive course despite treatment, who met criteria for TAFRO syndrome despite HHV-8 positivity.
RESUMEN
BACKGROUND: To report the neuro-ophthalmological findings in the TAFRO syndrome in a South American patient. METHODS: This is a case report of a patient with TAFRO syndrome. RESULTS: We present the case of a 66-year-old woman with TAFRO syndrome and multicentric Castleman disease, who developed ophthalmic manifestations, as a rare complication, including optic disk edema and serous retinal detachment, which improved with conventional therapy. CONCLUSIONS: The optic disk edema could be present as a neuro-ophthalmological finding in TAFRO syndrome. To the best of our knowledge, this is the first report on the ophthalmic manifestations in the TAFRO syndrome.