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1.
Polymers (Basel) ; 16(17)2024 Aug 27.
Artículo en Inglés | MEDLINE | ID: mdl-39274058

RESUMEN

This study focuses on enhancing the thermal properties and shape recovery performance of shape memory polymers (SMPs) through the application of carbon-based fillers. Single and mixed fillers were used to investigate their effects on the glass transition temperature (Tg), thermal conductivity, and shape recovery performance. The interaction among the three-dimensional (3D) structures of mixed fillers played a crucial role in enhancing the properties of the SMP. These interactions facilitated efficient heat transfer pathways and conserved strain energy. The application of mixed fillers resulted in substantial improvements, demonstrating a remarkable 290.37% increase in thermal conductivity for SMPCs containing 60 µm carbon fiber (CF) 10 wt% + graphite 20 wt% and a 60.99% reduction in shape recovery time for SMPCs containing CF 2.5 wt% + graphite 2.5 wt%. At a content of 15 wt%, a higher graphite content compared to CF improved the thermal conductivity by 37.42% and reduced the shape recovery time by 6.98%. The findings demonstrate that the application of mixed fillers, especially those with high graphite content, is effective in improving the thermal properties and shape recovery performance of SMPs. By using mixed fillers with high graphite content, the performance of the SMP showed significant improvement in situations where fast response times were required.

2.
Polymers (Basel) ; 16(17)2024 Aug 29.
Artículo en Inglés | MEDLINE | ID: mdl-39274093

RESUMEN

In four-dimensional additive manufacturing (4DAM), specific external stimuli are applied in conjunction with additive manufacturing technologies. This combination allows the development of tailored stimuli-responsive properties in various materials, structures, or components. For shape-changing functionalities, the programming step plays a crucial role in recovery after exposure to a stimulus. Furthermore, precise tuning of the 4DAM process parameters is essential to achieve shape-change specifications. Within this context, this study investigated how the structural arrangement of infill patterns (criss-cross and concentric) affects the shape memory effect (SME) of compression cold-programmed PLA under a thermal stimulus. The stress-strain curves reveal a higher yield stress for the criss-cross infill pattern. Interestingly, the shape recovery ratio shows a similar trend across both patterns at different displacements with shallower slopes compared to a higher shape fixity ratio. This suggests that the infill pattern primarily affects the mechanical strength (yield stress) and not the recovery. Finally, the recovery force increases proportionally with displacement. These findings suggest a consistent SME under the explored interval (15-45% compression) despite the infill pattern; however, the variations in the mechanical properties shown by the stress-strain curves appear more pronounced, particularly the yield stress.

3.
Materials (Basel) ; 17(17)2024 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-39274694

RESUMEN

This paper presents the experimental results of a study evaluating the mechanical and fatigue performance of welded Fe-Mn-Si SMA. For the experimental study, welded and welded-and-heat-treated Fe-Mn-Si SMA specimens were fabricated, and fatigue tests were performed at various stress amplitudes. In addition, direct tensile tests and recovery stress tests were also performed to evaluate the material properties of Fe-Mn-Si SMAs. The elastic modulus, yield strength, and tensile strength of the welded specimens were reduced by 35.4%, 12.1%, and 8.6%, respectively, compared to the values of the non-welded specimens. On the other hand, the elastic modulus, yield strength, and tensile strength of the welded-and-heat-treated Fe-Mn-Si SMA specimens were increased by 18.6%, 4.9%, and 1.3%, respectively, compared to the values of the welded specimens. Both welded and welded-and-heat-treated Fe-Mn-Si SMAs failed at lower cycles than the conventional Fe-Mn-Si SMAs at the same stress amplitude. High-cycle fatigue failure, characterized by cycles exceeding 104, typically occurs at relatively low stress levels within the elastic region, whereas low-cycle fatigue failure, generally occurring within cycles below 104, involves high stress levels that encompass both elastic and plastic deformation. Regardless of the welding condition, the stress amplitude at which Fe-Mn-Si SMA transitions from high-cycle to low-cycle failure exceeded the yield strength.

4.
ACS Appl Mater Interfaces ; 16(35): 46822-46833, 2024 Sep 04.
Artículo en Inglés | MEDLINE | ID: mdl-39178220

RESUMEN

Developing multifunctional polymers with excellent mechanical properties, outstanding shape memory characteristics, and good self-healing properties is a formidable challenge. Inspired by the woven cross-linking strategy, a series of supramolecular polyurethane (PU) with an interwoven network structure composed of covalent and supramolecular cross-linking nodes have been successfully synthesized by introducing the ureido-pyrimidinone (UPy) motifs into the PU skeleton. The best-performing sample exhibited ultrahigh strength (∼77.2 MPa) and toughness (∼312.7 MJ m-3), along with an ideal self-healing efficiency (up to 90.8% for 6 h) and satisfactory temperature-responsive shape memory effect (shape recovery rates up to 96.9%). Furthermore, it ensured recyclability. These favorable properties are mainly ascribed to the effective dissipation of strain energy due to the disassembly and reconfiguration of supramolecular nodes (i.e., quadruple hydrogen bonds (H-bonds) between UPy units), as well as the covalent cross-linking nodes that maintain the integrity of the polymer network structure. Thus, our work provides a universal strategy that breaks through the traditional contradictions and paves the way for the commercialization of high-performance multifunctional PU elastomers.

5.
Plant Physiol Biochem ; 215: 109060, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39182427

RESUMEN

Climate change will bring the interaction of stresses such as increased temperature and drought under high [CO2] conditions. This is likely to impact on crop growth and productivity. This study aimed to (i) determine the response of barley water relations to vegetative and anthesis drought periods under triple interaction conditions, (ii) test the possibility to prime barley plants for drought, and (iii) analyse the involvement of aquaporins in (i) and (ii). The water status of barley was not affected by drought at the vegetative stage, regardless of the environmental conditions. At the anthesis stage, when the water shortage period was more severe, barley plants growing under combined elevated CO2 and temperature conditions were able to maintain a better water status compared with plants grown under current conditions. Elevated CO2 and temperature conditions reduced the stomatal conductance and slowed down the plant water flow through a root-leaf hydraulic conductivity coordination. Leaf HvPIP2;1 and HvTIP1;1 aquaporins seemed to play a key role regulating barley's water flow, while leaf and root HvPIP2;5 provided basic level of water flow. At anthesis drought and under future combined conditions, plants showed a reduced cell dehydration and decrease in leaf relative water content compared with plants grown under current conditions. Exposure to a previous drought did not prime the water status of barley plants to a subsequent drought, but instead worsened the response under future conditions. This was due to an imbalance between the roots versus shoot development.


Asunto(s)
Cambio Climático , Sequías , Hordeum , Agua , Hordeum/metabolismo , Hordeum/fisiología , Hordeum/crecimiento & desarrollo , Agua/metabolismo , Acuaporinas/metabolismo , Hojas de la Planta/metabolismo , Hojas de la Planta/fisiología , Dióxido de Carbono/metabolismo , Proteínas de Plantas/metabolismo , Raíces de Plantas/metabolismo , Raíces de Plantas/fisiología , Raíces de Plantas/crecimiento & desarrollo
6.
Comput Methods Programs Biomed ; 254: 108306, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38968828

RESUMEN

BACKGROUND AND OBJECTIVE: Hepatitis virus infections are affecting millions of people worldwide, causing death, disability, and considerable expenditure. Chronic infection with hepatitis C virus (HCV) can cause severe public health problems because of their high prevalence and poor long-term clinical outcomes. Thus a fractional-order epidemic model of the hepatitis C virus involving partial immunity under the influence of memory effect to know the transmission patterns and prevalence of HCV infection is studied. Investigating the transmission dynamics of HCV makes the issue more interesting. The HCV epidemic model and worldwide dynamics are examined in this study. Calculate the basic reproduction number for the HCV model using the next-generation matrix technique. We determine the model's global dynamics using reproduction numbers, the Lyapunov functional approach, and the Routh-Hurwitz criterion. The model's reproduction number shows how the disease progresses. METHODS: A fractional differential equation model of HCV infection has been created. Maximum relevant parameters, such as fractional power, HCV transmission rate, reproduction number, etc., influencing the dynamic process, have been incorporated. The model's numerical solutions are obtained using the fractional Adams method. Finally, numerical simulations support the theoretical conclusions, showing the great agreement between the two. RESULTS: In the fractional-order HCV infection model, the memory effect, which is not seen in the classical model, was shown on graphs so that disease dynamics and vector compartments could be seen. We found that the fractional-order HCV infection model has more stages of freedom than regular derivatives. Fractional-order derivations, which may be the best and most reliable, explained bodily approaches better than classical order. CONCLUSION: The current study modeled and analyzed a fractional-order HCV infection model. The current approach results in a much better understanding of HCV transmission in a population, which leads to important insights into its spread and control, such as better treatment dosage for different age groups, identifying the best control measure, improving health, prolonging life, reducing the risk of HCV transmission, and effectively increasing the quality of life of HCV patients. The creation of a fractional-order HCV infection model, which provides a better understanding of HCV transmission dynamics and leads to significant insights for better treatment dosages, identification of optimal control measures, and ultimately improvement of the quality of life for HCV patients, is the study's major outcome.


Asunto(s)
Hepatitis C , Humanos , Hepatitis C/transmisión , Hepatitis C/epidemiología , Número Básico de Reproducción/estadística & datos numéricos , Simulación por Computador , Hepacivirus , Prevalencia , Modelos Teóricos , Algoritmos
7.
Sci Rep ; 14(1): 15859, 2024 07 09.
Artículo en Inglés | MEDLINE | ID: mdl-38982127

RESUMEN

Computational models and eye-tracking research suggest that encoding variability accounts for the reduced recognition of targets (A) when paired with non-corresponding lures (B') relative to corresponding lures (A'). The current study examined whether neural activity during learning coincided with subsequent performance on the forced-choice Mnemonic Similarity Task (MST). Event-related potential responses were collected during encoding while young adults completed A-B' and A-A' trials of the forced-choice MST. Consistent with previous research, performance was lower on A-B' trials than A-A' trials. The subsequent memory effect was not significant for the A-A' test format. However, for A-B' trials, we observed a significant Accuracy × Stimulus interaction 1000-1200 ms poststimulus onset across frontal and fronto-central electrodes. As hypothesized, subsequently correct A-B' trials were associated with a larger amplitude response at encoding to the target (A) than the original version of the non-corresponding lure (B). However, subsequently incorrect trials were associated with a larger amplitude response to the non-corresponding lure (B) than the target stimulus (A). These findings provide additional support for the effect of encoding variability on mnemonic discrimination.


Asunto(s)
Conducta de Elección , Potenciales Evocados , Humanos , Masculino , Femenino , Potenciales Evocados/fisiología , Adulto Joven , Adulto , Conducta de Elección/fisiología , Electroencefalografía , Memoria/fisiología , Adolescente , Discriminación en Psicología/fisiología , Reconocimiento en Psicología/fisiología
8.
Polymers (Basel) ; 16(14)2024 Jul 09.
Artículo en Inglés | MEDLINE | ID: mdl-39065283

RESUMEN

One of the useful features of 3D-printed specimens of recycled polyethylene terephthalate glycol (R-PETG) is the ability to repetitively develop free recovery as well as the work-generating, shape-memory effect. This behavior is enabled by the R-PETG's capacity to stiffen during cooling, thus allowing for a new temporary shape to be induced. Aiming to devise an explanation for the polymer's stiffening, in this study, the variation in some of the R-PETG's parameters during cooling are emphasized and discussed. The evolution of an R-PETG filament's shape was monitored during room-temperature-bending heating-cooling cycles. Straight-shape recovery and the complete loss of stiffness were observed at the start and the end of heating, respectively, followed by the forced straightening of the filament, performed by the operator, around 40 °C, during cooling. The tests performed by dynamic mechanical analysis disclosed the rise of the storage modulus (E') after 100 °C heating followed by either liquid-nitrogen- or air-cooling to room temperature, in such a way that E' was always larger after cooling than initially. Static tests emphasized a peculiar stress variation during a heating-cooling cycle applied in air, within the heating chamber of the tensile testing machine. Tensile-failure tests were performed at -10 °C at a rate of 100 mm/min, with specimens printed at various deposition directions between 10 and 40° to the transversal direction. The specimens printed at 40°, which had the largest ultimate strains, were broken with tensile rates between 100 and 500 mm/min. Deformation rate increase favored the shift from crazing to delamination failure modes. The correlation between the structural changes, the sharp E' increase on heating, and the stiffening induced by cooling represents a novel approach that enables the use of 3D-printed R-PETG for the fabrication of the active parts of low-priced lightweight resettable actuators.

9.
ACS Appl Mater Interfaces ; 16(31): 41211-41222, 2024 Aug 07.
Artículo en Inglés | MEDLINE | ID: mdl-39054697

RESUMEN

Organic synaptic transistors are a promising technology for advanced electronic devices with simultaneous computing and memory functions and for the application of artificial neural networks. In this study, the neuromorphic electrical characteristics of organic synaptic electrolyte-gated transistors are correlated with the microstructural and interfacial properties of the active layers. This is accomplished by utilizing a semiconducting/insulating polyblend-based pseudobilayer with embedded source and drain electrodes, referred to as PB-ESD architecture. Three variations of poly(3-hexylthiophene) (P3HT)/poly(methyl methacrylate) (PMMA) PB-ESD-based organic synaptic transistors are fabricated, each exhibiting distinct microstructures and electrical characteristics, thus serving excellent samples for exploring the critical factors influencing neuro-electrical properties. Poor microstructures of P3HT within the active layer and a flat active layer/ion-gel interface correspond to typical neuromorphic behaviors such as potentiated excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), and short-term potentiation (STP). Conversely, superior microstructures of P3HT and a rough active layer/ion-gel interface correspond to significantly higher channel conductance and enhanced EPSC and PPF characteristics as well as long-term potentiation behavior. Such devices were further applied to the simulation of neural networks, which produced a good recognition accuracy. However, excessive PMMA penetration into the P3HT conducting channel leads to features of a depressed EPSC and paired-pulse depression, which are uncommon in organic synaptic transistors. The inclusion of a second gate electrode enables the as-prepared organic synaptic transistors to function as two-input synaptic logic gates, performing various logical operations and effectively mimicking neural modulation functions. Microstructure and interface engineering is an effective method to modulate the neuromorphic behavior of organic synaptic transistors and advance the development of bionic artificial neural networks.

10.
Materials (Basel) ; 17(11)2024 May 29.
Artículo en Inglés | MEDLINE | ID: mdl-38893898

RESUMEN

Shape memory alloy (SMA), a type of smart material, is widely used in the design of reinforcement and repair, isolation, and shock absorption of building structures because of its outstanding characteristics, such as the shape memory effect (SME), superelasticity (SE), and high damping. It not only improves the bearing capacity, ductility, and mechanical properties of the structural components of buildings but can also effectively slow down the strong response of engineering structures under the effect of an earthquake. It plays a key role in energy dissipation and shock absorption as well as sustainable development. To promote the application of SMA in building structures, this paper summarizes the research on the use of SMA as a reinforcing material in building structures, including work related to SMA material characteristics and types, SMA-reinforced structural components, and SMA isolation devices. In addition, the shortcomings of SMA applications in building structures are analyzed, and valuable suggestions for future research methods are put forward. SMA has been applied to engineering practice in the form of embedded and external reinforcement, which shows that it has broad application prospects in future buildings.

11.
Materials (Basel) ; 17(11)2024 Jun 05.
Artículo en Inglés | MEDLINE | ID: mdl-38894012

RESUMEN

Memristors, since their inception, have demonstrated remarkable characteristics, notably the exceptional reconfigurability of their memory. This study delves into electroforming-free YMnO3 (YMO)-based resistive switches, emphasizing the reconfigurable memory effect in multiferroic YMO thin films with metallically conducting electrodes and their pivotal role in achieving adaptable frequency responses in impedance circuits consisting of reconfigurable YMO-based resistive switches and no reconfigurable passive elements, e.g., inductors and capacitors. The multiferroic YMO possesses a network of charged domain walls which can be reconfigured by a time-dependent voltage applied between the metallically conducting electrodes. Through experimental demonstrations, this study scrutinizes the impedance response not only for individual switch devices but also for impedance circuitry based on YMO resistive switches in both low- and high-resistance states, interfacing with capacitors and inductors in parallel and series configurations. Scrutinized Nyquist plots visually capture the intricate dynamics of impedance circuitry, revealing the potential of electroforming-free YMO resistive switches in finely tuning frequency responses within impedance circuits. This adaptability, rooted in the unique properties of YMO, signifies a paradigm shift heralding the advent of advanced and flexible electronic technologies.

12.
Front Chem ; 12: 1396862, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38841336

RESUMEN

Kinetic hydrate inhibitor laboratory testing before field application is one of the key priorities in the oil and gas industry. The common induction-time-based technique is often used to evaluate and screen for kinetic hydrate inhibitors (KHIs). However, the main challenge relates to the stochastic nature of hydrate nucleation observed in fresh systems, which often results in scattered data on hydrate formation with unacceptable uncertainties. A much more precise KHI evaluation method, called crystal growth inhibition (CGI), provides comprehensive insights into the inhibitory behavior of a kinetic hydrate inhibitor, including both hydrate formation and decomposition. Given that industry does not require this much information, it is not feasible to expend either much time or cash on this strategy. This study aims to provide a cost-effective technique that presents maximum data accuracy and precision with relatively little time and cost expenditure. Hence, the impact of water-hydrate memory on improving the accuracy and repeatability of the results of the induction-time-based technique (IT method) was examined. First, the concept of water-hydrate memory, which contains information about how it is created, was reviewed, and then, the factors influencing it were identified and experimentally investigated, like the heating rate of hydrate dissociation and the water-hydrate memory target temperature during heating. Finally, a procedure was developed based on the background information in the earlier sections to compare the consistency of the results, originating from the conjunction of water-hydrate memory with the IT technique. The results of replications at KHI evaluation target temperatures of 12.3-12.4°C and 11.5-11.7°C showed that more repeatable data were obtained by applying water-hydrate memory, and a more conclusive decision was made in evaluating KHI performance than with an IT method. It seems that combining the IT method with water-hydrate memory, introduced as the "HME method", can lead to more definitive evaluations of KHIs. This approach is expected to gain in popularity, even surpassing the accurate but complex and time-consuming CGI method.

13.
Artículo en Inglés | MEDLINE | ID: mdl-38837200

RESUMEN

Cement-based products are the synthetic materials most used by humans, with consequent environmental impacts. One strategy that can assist in mitigating the adverse environmental effects of these materials involves the incorporation of multifunctional nanostructured additives. The objective of this work was to demonstrate the efficacy of incorporating mixed oxides (MO) derived from layered double hydroxides (LDH) to control the rheology and porosity of cement-based matrices. Thermal aging of LDH enabled the preparation of MO with different specific surface areas (SSA) for incorporation in different amounts in Portland cement. A low proportion of MO and low SSA increased workability by 22%. In contrast, a high proportion of MO and high SSA led to a 2.4-fold acceleration of cement consolidation and a 36.9% decrease of the porosity of the composite. These features could be attributed to additive-matrix interactions, with the LDH memory effect playing key roles in the cement crystal seed process and in competition for the absorption of free water within the cement paste. Therefore, the unprecedent results obtained suggest that the quantity and SSA of MO are key parameters to fine-tune the paste rheology and structure of hidrated cement. The MO materials showed easy adaptability and excellent potential for use as multifunctional additives in the production of eco-friendly, high-performance cement paste formulations with controllable properties according to the desired application.

14.
Comput Biol Med ; 178: 108682, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38861897

RESUMEN

During any infectious disease outbreak, effective and timely quarantine of infected individuals, along with preventive measures by the population, is vital for controlling the spread of infection in society. Therefore, this study attempts to provide a mathematically validated approach for managing the epidemic spread by incorporating the Monod-Haldane incidence rate, which accounts for psychological effects, and a saturated quarantine rate as Holling functional type III that considers the limitation in quarantining of infected individuals into the standard Susceptible-Exposed-Infected-Quarantine-Recovered (SEIQR) model. The rate of change of each subpopulation is considered as the Caputo form of fractional derivative where the order of derivative represents the memory effects in epidemic transmission dynamics and can enhance the accuracy of disease prediction by considering the experience of individuals with previously encountered. The mathematical study of the model reveals that the solutions are well-posed, ensuring nonnegativity and boundedness within an attractive region. Further, the study identifies two equilibria, namely, disease-free (DFE) and endemic (EE); and stability analysis of equilibria is performed for local as well as global behaviours for the same. The stability behaviours of equilibria mainly depend on the basic reproduction number R0 and its alternative threshold T0 which is computed using the Next-generation matrix method. It is investigated that DFE is locally and globally asymptotic stable when R0<1. Furthermore, we show the existence of EE and investigate that it is locally and globally asymptotic stable using the Routh-Hurwitz criterion and the Lyapunov stability theorem for fractional order systems with R0>1 under certain conditions. This study also addresses a fractional optimal control problem (FOCP) using Pontryagin's maximum principle aiming to minimize the spread of infection with minimal expenditure. This approach involves introducing a time-dependent control measure, u(t), representing the behavioural response of susceptible individuals. Finally, numerical simulations are presented to support the analytical findings using the Adams Bashforth Moulton scheme in MATLAB, providing a comprehensive understanding of the proposed SEIQR model.


Asunto(s)
Cuarentena , Humanos , Incidencia , Epidemias , Enfermedades Transmisibles/epidemiología , Enfermedades Transmisibles/transmisión , Modelos Epidemiológicos , Modelos Biológicos , Número Básico de Reproducción , COVID-19/epidemiología , COVID-19/prevención & control , COVID-19/transmisión , Simulación por Computador
15.
Perception ; 53(8): 563-578, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38725355

RESUMEN

Observers can rapidly extract the mean emotion from a set of faces with remarkable precision, known as ensemble coding. Previous studies have demonstrated that matched physical backgrounds improve the precision of ongoing ensemble tasks. However, it remains unknown whether this facilitation effect still occurs when matched social information is perceived from the backgrounds. In two experiments, participants decided whether the test face in the retrieving phase appeared more disgusted or neutral than the mean emotion of the face set in the encoding phase. Both phases were paired with task-irrelevant animated backgrounds, which included either the forward movement trajectory carrying the "cooperatively chasing" information, or the backward movement trajectory conveying no such chasing information. The backgrounds in the encoding and retrieving phases were either mismatched (i.e., forward and backward replays of the same trajectory), or matched (i.e., two identical forward movement trajectories in Experiment 1, or two different forward movement trajectories in Experiment 2). Participants in both experiments showed higher ensemble precisions and better discrimination sensitivities when backgrounds matched. The findings suggest that consistent social information perceived from memory-related context exerts a context-matching facilitation effect on ensemble coding and, more importantly, this effect is independent of consistent physical information.


Asunto(s)
Expresión Facial , Reconocimiento Facial , Percepción Social , Humanos , Masculino , Femenino , Adulto Joven , Reconocimiento Facial/fisiología , Adulto , Emociones/fisiología
16.
J Trace Elem Med Biol ; 84: 127467, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38704916

RESUMEN

BACKGROUND: Mercury (Hg) is a persistent pollutant occurring in the environment able to transition between different species. It can therefore be found in air, soil and water reservoirs becoming a present concern for the general population but also sensitive populations like pregnant women. Therefore, investigating organ-specific transfer mechanisms of Hg is mandatory for Hg toxicity testing. For this, an in vitro system using microporous inserts to monitor the transfer across an in vitro placental barrier has been used. However, due to the cytotoxicity of Hg only low concentrations (1.26 ×10-4 - 1.36 ×10-2 µg/µL Hg) can be applied, making Hg determination in cell culture medium using inductively coupled plasma-optical emission spectrometry challenging, especially when these trace amounts should be determined alongside other trace elements which are naturally occurring in cells and cell culture medium like the essential metals manganese (Mn), iron (Fe), copper (Cu), and zinc (Zn). Additionally, Hg analysis on an ICP system holds also a number of challenges like a persistent memory effect and instability of Hg standard solutions. METHODS: The development of a rapid and sensitive ICP-OES method to determine Hg in different matrices like cell culture medium and cells has been performed on an Avio 220 Max ICP-OES (Perkin-Elmer) equipped with a cyclonic spray chamber and MicroMist® nebulizer. Cell lysates and cell culture medium were diluted in a mixture of 0.2 % L-cysteine, 2 % HNO3 and 0.1 % HCl and directly introduced into the ICP-OES system. Further method development included the suitability of the analysis of multiple elements like Mn, Fe, Cu, and Zn as well as the determination of the limit of detection and limit of quantification. RESULTS: The combination of 0.2 % L-cysteine, 2 % HNO3 and 0.1 % HCl is able to bind and stabilize Hg ions in standard solutions and in biological matrices over a wide dynamic concentration range (1 - 500 µg/L) also alongside other metals like Mn, Fe, Cu and Zn without losses of sensitivity. A short run time of 3 min enables high throughput analysis. Additionally, the high salt and carbon concentrations in the culture medium do not affect Hg sensitivity using the ICP-OES. CONCLUSION: This method is a useful tool for the quantification of Hg in a variety of complex matrices including cells and cell culture media (high salt and carbon-rich (∼1 % each)) with high sensitivity and minimal sample preparation allowing high throughput. Furthermore, not only Hg can be determined in biological matrices, but even multiple elemental analysis can be carried out to address the effect of Hg on other metals homeostasis.


Asunto(s)
Cisteína , Mercurio , Mercurio/análisis , Cisteína/análisis , Cisteína/química , Humanos , Calibración
17.
Proc Natl Acad Sci U S A ; 121(19): e2322424121, 2024 May 07.
Artículo en Inglés | MEDLINE | ID: mdl-38696465

RESUMEN

Evolution equations with convolution-type integral operators have a history of study, yet a gap exists in the literature regarding the link between certain convolution kernels and new models, including delayed and fractional differential equations. We demonstrate, starting from the logistic model structure, that classical, delayed, and fractional models are special cases of a framework using a gamma Mittag-Leffler memory kernel. We discuss and classify different types of this general kernel, analyze the asymptotic behavior of the general model, and provide numerical simulations. A detailed classification of the memory kernels is presented through parameter analysis. The fractional models we constructed possess distinctive features as they maintain dimensional balance and explicitly relate fractional orders to past data points. Additionally, we illustrate how our models can reproduce the dynamics of COVID-19 infections in Australia, Brazil, and Peru. Our research expands mathematical modeling by presenting a unified framework that facilitates the incorporation of historical data through the utilization of integro-differential equations, fractional or delayed differential equations, as well as classical systems of ordinary differential equations.

18.
Adv Mater ; 36(36): e2402517, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38808656

RESUMEN

Miniature shape-morphing soft actuators driven by external stimuli and fluidic pressure hold great promise in morphing matter and small-scale soft robotics. However, it remains challenging to achieve both rich shape morphing and shape locking in a fast and controlled way due to the limitations of actuation reversibility and fabrication. Here, fully 3D-printed, sub-millimeter thin-plate-like miniature soft hydraulic actuators with shape memory effect (SME) for programable fast shape morphing and shape locking, are reported. It combines commercial high-resolution multi-material 3D printing of stiff shape memory polymers (SMPs) and soft elastomers and direct printing of microfluidic channels and 2D/3D channel networks embedded in elastomers in a single print run. Leveraging spatial patterning of hybrid compositions and expansion heterogeneity of microfluidic channel networks for versatile hydraulically actuated shape morphing, including circular, wavy, helical, saddle, and warping shapes with various curvatures, are demonstrated. The morphed shapes can be temporarily locked and recover to their original planar forms repeatedly by activating SME of the SMPs. Utilizing the fast shape morphing and locking in the miniature actuators, their potential applications in non-invasive manipulation of small-scale objects and fragile living organisms, multimodal entanglement grasping, and energy-saving manipulators, are demonstrated.

19.
Chem Asian J ; 19(14): e202400181, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-38705859

RESUMEN

In Li-ion batteries, the origin of memory effect in Al-doped Li4Ti5O12 has been revealed as the reversible Al-ion switching between 8a and 16c sites in the spinel structure, but it is still not clear about that for olivine LiFePO4, which is one of the most important cathode materials. In this work, a series of Na-doped and Ti-doped LiFePO4 are prepared in a high-temperature solid-state method, electrochemically investigated in Li-ion batteries and characterized by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Magic-Angle-Spinning Nuclear Magnetic Resonance (MAS NMR). Compared with non-doped LiFePO4, the Ti doping can simultaneously suppress the memory effect and the Li-Fe anti-site, while they are simultaneously enhanced by the Na doping. Meanwhile, the Ti doping improves the electrochemical performance of LiFePO4, opposite to the Na doping. Accordingly, a schematic diagram of phase transition is proposed to interpret the memory effect of LiFePO4, in which the memory effect is attributed to the defect of Li-Fe anti-site.

20.
Micromachines (Basel) ; 15(5)2024 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-38793176

RESUMEN

Microcatheters capable of active guidance have been proven to be effective and efficient solutions to interventional surgeries for cardiovascular and cerebrovascular diseases. Herein, a novel microcatheter made of two biocompatible materials, shape memory alloy (SMA) and polyethylene (PE), is proposed. It consists of a reconfigurable distal actuator and a separate polyethylene catheter. The distal actuator is created via embedding U-shape SMA wires into the PE base, and its reconfigurability is mainly dominated by the shape memory effect (SME) of SMA wires, as well as the effect of thermal mismatch between the SMA and PE base. A mathematical model was established to predict the distal actuator's deformation, and the analytical solutions show great agreement with the finite element results. Structural optimization of such microcatheters was carried out using the verified analytical model, followed by fabrication of some typical prototypes. Experimental testing of their mechanical behaviors demonstrates the feasibility of the structural designs, and the reliability and accuracy of the mathematical model. The active microcatheter, together with the prediction model, will lay a solid foundation for rapid development and optimization of active navigation strategies for vascular interventions.

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