1.
Eur J Med Chem
; 76: 291-300, 2014 Apr 09.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24589485
RESUMEN
(-)-Massoialactone, an α,ß-unsaturated δ-lactone isolated from Cryptocarya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties.