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The traditional classifications of motor skills nature (open vs closed; fine vs gross) have not been considered in handedness investigations. Instead, previous research focused on comparing complex vs less complex motor behaviour, leaving a gap in the literature. We compared manual preference between different motor skill characteristics, namely: fine and closed (FC), gross and closed (GC) and gross and open (GO) tasks. The hand preference was assessed with the Global Lateral Preference Inventory in four hundred and forty participants (244 women) aged from 18 to 59 years old. By assessing the degree and direction of handedness in different motor skills, our results showed a stronger lateralization pattern for FC motor skills as compared to GC and GO, with GO also being less lateralized than GC. Our results expand those of previous investigations that used the motor skill complexity definitions by showing how handedness can also be modulated by the interaction between classic motor skills classifications. Future research should consider fine vs. gross and open vs. closed classifications when selecting tasks for analysis of asymmetries of preference.

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Os dentistas são um grupo de alto risco para o desenvolvimento de doenças de desordens musculoesqueléticas e tendo em vista que o sistema de produção industrial desenvolve produtos que atendem a maioria da população destra, os estudantes canhotos precisam se adequar a uma formação acadêmica, usando instrumentais, cadeiras odontológicas eoutros objetos projetados para destros. O presente trabalho teve como objetivo a coletade informações sobre os canhotos nos cursos de Odontologia da cidade de Uberlândia ­Minas Gerais. Foram incluídos todos os alunos canhotos matriculados no ano de 2022 e que estavam cursando ou já cursaram disciplinas com atividades laboratoriais ou clínicas. Questionários foram aplicados para identificação do perfil, das dificuldades, da ergonomia e das dores osteomusculares dos alunos canhotos em suas atividades. Os dados foram em seguida tabulados e passaram por análise estatística. Da quantidade total de alunos das três instituições (n=1.578), foram entrevistados 45 (2,8%) alunos canhotos, sendo a maioria feminina (80%), na qual identificou-se um posicionamento inadequado do operador canhoto quando comparado ao preconizado pela ISO-FDI, além da limitação de movimento na presença de auxiliar (82,2%). Os locais com maior frequência de dor/desconforto foram: pescoço (79%), costas superior esquerda (63%) e inferior esquerda (61%) e punhos/ mãos esquerda (56%). A intensidade da dor variou entre alguma, moderada e bastante. O impedimento de realizar atividades diárias foi relatado por 17% dos alunos (n=7) e destes somente 1 buscou atendimento médico. Não houve diferença estatística na comparação entre instituição pública e privada. Diante dos resultados, concluiu-se que os canhotos representam minoria dos alunos de Odontologia e apresentam várias regiões de dor/ desconforto devido às adaptações e posturas erradas durante os atendimentos. Apesar de grande parte apresentar dor, poucos tiveram impedimento de atividades rotineiras ou procuraram ajuda médica(AU)

Dentists are a high risk group for the development of musculoskeletal disorders and considering that the industrial production system develops products that serve the majority of the right-handed population, lefthanded students need to adapt to an academic training, using instruments, dental chairs and other objects designed for right-handers. This study aimed to collect information about left-handers in Dentistry courses in the city of Uberlândia - Minas Gerais. All left- handed students enrolled in the year 2022 and who were taking or had taken courses with laboratory or clinical activities were included. Questionnaires were applied to identify the profile, difficulties, ergonomics and musculoskeletal pain of left-handed students in their activities. The data were tabulated and then undergo statistical analysis. Of the total number of students from the three institutions (n=1,578), 45 (2.8%) left-handed students were interviewed, the majority being female (80%), in which an inadequate positioning of the left-handed operator was identified when compared to the recommended one by ISO-FDI, in addition to limitation of movement in the presence of an assistant (82.2%). The places with the highest frequency of pain/discomfort were: neck (79%), upper left back (63%) and lower left back (61%) and left wrists/hands (56%). The intensity of pain varied between some, moderate and a lot. The impediment to carrying out daily activities was reported by 17% of the students (n=7) and of these, only 1 sought medical attention. There was no statistical difference when comparing public and private institutions. In view of the results, it was concluded that left-handers represent a minority of dentistry students and have several regions of pain/discomfort due to adaptations and wrong postures during consultations. Although most of them had pain, few were prevented from performing routine activities or sought medical help(AU)

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En la Educación Física la lateralidad motriz se debe desarrollar a temprana edad. El objetivo de esta investigación fue analizar de manera integral la lateralidad de estudiantes de décimo año en la clase de Educación Física, a partir de sus necesidades y percepciones, para el diseño de actividades recreativas inclusivas que aborden trastornos de lateralidad. El estudio fue de tipo explicativo y corte transversal con un enfoque mixto y se desarrolló en ocho instituciones educativas particulares de la ciudad de Quito. Se seleccionaron 14 docentes para la entrevista y se evaluaron, con el test validado de Harris, a 688 estudiantes de décimo año, se identificó a 40 de ellos con trastorno de lateralidad, y se les aplicó una encuesta, con lo que se pudo diseñar una propuesta de intervención de actividades recreativas inclusivas que aborden este trastorno. Los datos se analizaron en Excel, luego de haber aplicado una escala de Likert en la encuesta, para comprender las experiencias, percepciones y adaptaciones en profundidad. Esta investigación arroja luz sobre la importancia de considerar la lateralidad en el diseño de actividades recreativas inclusivas, además se evidenció que la adaptación curricular y la personalización son claves para atender las necesidades específicas de estos estudiantes.

Na Educação Física a lateralidade motora deve ser desenvolvida desde cedo. O objetivo desta pesquisa foi analisar de forma abrangente a lateralidade dos alunos do décimo ano das aulas de Educação Física, a partir de suas necessidades e percepções, para o desenho de atividades lúdicas inclusivas que abordem os transtornos de lateralidade. O estudo foi explicativo e transversal com abordagem mista e foi desenvolvido em oito instituições de ensino privadas da cidade de Quito. Foram selecionados 14 professores para a entrevista e 688 alunos do décimo ano foram avaliados com o teste de Harris validado, 40 deles foram identificados com transtorno de lateralidade, e foi aplicado um questionário a eles, para que fosse apresentada uma proposta de intervenção para atividades lúdicas inclusivas que abordassem esse assunto; transtorno. Os dados foram analisados ​​em Excel, após aplicação de escala Likert na pesquisa, para compreender em profundidade as experiências, percepções e adaptações. Esta pesquisa esclarece a importância de considerar a lateralidade na concepção de atividades recreativas inclusivas. Também mostrou que a adaptação curricular e a personalização são fundamentais para atender às necessidades específicas desses alunos.

In Physical Education, motor laterality must be developed at an early age. The objective of this research was to comprehensively analyze the laterality of tenth-year students in Physical Education class, based on their needs and perceptions, for the design of inclusive recreational activities that address laterality disorders. The study was explanatory and cross-sectional with a mixed approach and was developed in eight private educational institutions in the city of Quito. 14 teachers were selected for the interview and 688 tenth-grade students were evaluated with the validated Harris test; 40 of them were identified with laterality disorder, and a survey was applied to them, so that an intervention proposal for inclusive recreational activities that address this disorder. The data was analyzed in Excel, after having applied a Likert scale in the survey, to understand the experiences, perceptions and adaptations in depth. This research sheds light on the importance of considering laterality in the design of inclusive recreational activities. It also showed that curricular adaptation and personalization are key to addressing the specific needs of these students.

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SUMMARY: The dorsal interosseous muscles (DIM) are intrinsic muscles of the hand located dorsally between metacarpal bones, which play a role in finger abduction. Anatomical variations of these muscles in terms of form and length have been well documented, but variations regarding sex and laterality are underexplored. The aim of this study was to investigate the morphology and morphometry of the DIM of the hand regarding sexual dimorphism and laterality. Twenty human cadavers belonging to the white individuals (n = 40 hands) with known sex and laterality were used for this study. DIMs were dissected and observed for morphology. Also, a digital calliper was used to measure the midpoint length of the DIM. The origin and insertion of all the DIM were normal with the left hand having no additional, supernumerary, and absent muscles in each compartment. The variations were only found on the right side and predominant in females: 2 out of 11 (18.18%) hands containing a space with a supernumerary muscle; 1 out of 11 (9.09%) hands having a space with a double muscle; and 1 out of 11 (9.09%) hands having a compartment with a unipennate muscle. In males, 1 out of 9 (11.11%) hands had a compartment with a supernumerary muscle. The mean midpoint length of each muscle in females and males in both hands from the first to the fourth muscle, respectively, was documented. In females on the left: 46.79 ± 3.56; 42.62 ± 3.57; 49.02 ± 4.21; 41.66 ± 2.15 and right: 47.30 ± 2.49; 39.27 ± 4.14; 45.69 ± 4.64; 38.12 ± 4.08. In males, it was on the left: 50.01 ± 3.95; 41.98 ± 3.79; 47.90 ± 4.83; 41.79 ± 4.25, and on the right: 46.65 ± 2.09; 39.01 ± 4.25; 47.47 ± 3.41; 38.31 ± 4.40. The mean midpoint length of the DIM was relatively higher on the left hand compared to the right hand in both females and males. In this study, variations regarding the supernumerary muscle, double interosseous space, and unipennate muscles were only observed on the right-hand side and predominantly in females, an insight that may guide in the treatment of fractures, stiffness of the hand, and compartment syndromes.

Los músculos interóseos dorsales (DIM) son músculos intrínsecos de la mano ubicados dorsalmente entre los huesos metacarpianos, que desempeñan un papel en la abducción de los dedos. Las variaciones anatómicas de estos músculos en términos de forma y longitud están bien documentadas, pero las variaciones con respecto al sexo y la lateralidad están poco exploradas. El objetivo de este estudio fue investigar la morfología y morfometría de los DIM de la mano con respecto al dimorfismo sexual y la lateralidad. Para este estudio se utilizaron veinte cadáveres humanos pertenecientes a individuos blancos (n = 40 manos) con sexo y lateralidad conocidos. Los DIM se diseccionaron y observaron para determinar su morfología. Además, se utilizó un calibrador digital para medir la longitud del punto medio del DIM. El origen y la inserción de todos los DIM fueron normales y la mano izquierda no tenía músculos adicionales, supernumerarios y ausentes en cada compartimento. Las variaciones se encontraron sólo en el lado derecho y predominaron en el sexo femenino: 2 de 11 (18,18%) manos contenían un espacio con un músculo supernumerario; 1 de cada 11 (9,09%) manos presentando un espacio con doble músculo; y 1 de cada 11 (9,09%) manos presentaba un compartimento con músculo unipenate. En los hombres, 1 de cada 9 (11.11%) manos tenía un compartimento con un músculo supernumerario. Se documentó la longitud media del punto medio de cada músculo en mujeres y hombres en ambas manos desde el primer al cuarto músculo, respectivamente. En mujeres de izquierda: 46,79 ± 3,56; 42,62 ± 3,57; 49,02 ± 4,21; 41,66 ± 2,15 y derecha: 47,30 ± 2,49; 39,27 ± 4,14; 45,69 ± 4,64; 38,12 ± 4,08. En los varones fue hacia la izquierda: 50,01 ± 3,95; 41,98 ± 3,79; 47,90 ± 4,83; 41,79 ± 4,25, y a la derecha: 46,65 ± 2,09; 39,01 ± 4,25; 47,47 ± 3,41; 38,31 ± 4,40. La longitud media del punto medio del DIM fue relativamente mayor en la mano izquierda en comparación con la derecha tanto en mujeres como en hombres. En este estudio, las variaciones con respecto al músculo supernumerario, el doble espacio interóseo y los músculos unipennados sólo se observaron en el lado derecho y predominantemente en el sexo femenino, un conocimiento que puede guiar en el tratamiento de fracturas, rigidez de la mano y síndromes compartimentales.

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There are a variety of inventories available to evaluate human lateral preference, but no previous review has systematically analyzed and compared them. We conducted a systematic literature review to identify these inventories and describe their characteristics (e.g., dimensions, scales, tasks, psychometric properties). We included 26 articles, each presenting a different inventory to assess lateral preference, published between 1900 and 2022, selected from the following databases: PubMed, SportDiscus, APA PsycNET, and Web of Science. These inventories analyzed tasks performed in everyday life (domestic, work-related, sports, and leisure/recreation activities), covering hand, foot, hearing, visual and other non-usual lateral preference dimensions, such as trunk and head. Most inventories classified individuals based on the direction (left, indifferent or right preference) and degree (consistent or moderate) of laterality. However, many of the reviewed inventories lack established psychometric verification in their original publication, such as validity, reliability, responsiveness, and practical applicability. Inventories also presented tasks that may be specific to a given cultural setting, limiting their application across different countries. Based on these findings, we provide a comprehensive guide for researchers to select a lateral preference assessment tool, but also advocate for a new inventory with a broader approach, containing more than one dimension of lateral preference (i.e., not only handedness) and tasks that are common to different cultures to enhance practical applicability worldwide.

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El insuficiente estudio de los patrones de lateralidad en el deporte limita el diagnóstico del tipo de motricidad y obstaculiza notablemente los procesos de planificación del entrenamiento, desde las individualidades de los futbolistas, para buscar el rendimiento óptimo. El objetivo del estudio fue caracterizar los patrones de lateralidad predominantes en futbolistas masculinos del equipo Habana, categoría juvenil. Se desarrolló un estudio exploratorio y descriptivo que aplicó métodos de carácter teórico, empírico (entrevistas y encuestas), y estadístico-matemático (por medio de hojas de cálculo de Excel). Fueron aplicados seistest (Ojo director, Mano directora, Lateralidad de cadera, Lateralidad de hombro, Pierna dinámica y Pie director), con instrumentos internacionales contextualizados y avalados en investigaciones especializadas para su uso en Cuba. La heterogeneidad de la muestra mostró la tendencia genérica en el comportamiento preferencial de los futbolistas estudiados.

O estudo insuficiente dos padrões de lateralidade no esporte limita o diagnóstico do tipo de motricidade e dificulta significativamente os processos de planejamento do treinamento, a partir das individualidades dos jogadores de futebol, a fim de buscar um desempenho ideal. O objetivo do estudo foi caracterizar os padrões predominantes de lateralidade em jogadores de futebol masculino da equipe Habana, categoria juvenil. Foi realizado um estudo exploratório e descritivo com métodos teóricos, empíricos (entrevistas e pesquisas) e estatístico-matemáticos (por meio de planilhas do Excel). Foram aplicados seis testes (Olho Direcionado, Mão Direcionada, Lateralidade do Quadril, Lateralidade do Ombro, Perna Dinâmica e Pé Direcionado), com instrumentos internacionais contextualizados e aprovados em pesquisas especializadas para uso em Cuba. A heterogeneidade da amostra mostrou a tendência genérica no comportamento preferencial dos jogadores de futebol estudados.

The insufficient study of laterality patterns in sport limits the diagnosis of the type of motor skills and significantly hinders the training planning processes, from the individualities of the soccer players, to seek optimal performance. The objective of the study was to characterize the predominant laterality patterns in male soccer players of the Havana team, youth category. An exploratory and descriptive study was developed that applied theoretical, empirical (interviews and surveys), and statistical-mathematical methods (using Excel spreadsheets). Six tests were applied (Directing eye, Directing hand, Laterality of the hip, Laterality of the shoulder, Dynamic leg and Directing foot), with contextualized international instruments and endorsed by specialized research for their use in Cuba. The heterogeneity of the sample showed the generic trend in the preferential behavior of the soccer players studied.

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Breast cancer is a complex and heterogeneous disease that displays diverse molecular subtypes and clinical outcomes. Although it is known that the location of tumors can affect their biological behavior, the underlying mechanisms are not fully understood. In our previous study, we found a differential methylation profile and membrane potential between left (L)- and right (R)-sided breast tumors. In this current study, we aimed to identify the ion channels responsible for this phenomenon and determine any associated phenotypic features. To achieve this, experiments were conducted in mammary tumors in mice, human patient samples, and with data from public datasets. The results revealed that L-sided tumors have a more depolarized state than R-sided. We identified a 6-ion channel-gene signature (CACNA1C, CACNA2D2, CACNB2, KCNJ11, SCN3A, and SCN3B) associated with the side: L-tumors exhibit lower expression levels than R-tumors. Additionally, in silico analyses show that the signature correlates inversely with DNA methylation writers and with key biological processes involved in cancer progression, such as proliferation and stemness. The signature also correlates inversely with patient survival rates. In an in vivo mouse model, we confirmed that KI67 and CD44 markers were increased in L-sided tumors and a similar tendency for KI67 was found in patient L-tumors. Overall, this study provides new insights into the potential impact of anatomical location on breast cancer biology and highlights the need for further investigation into possible differential treatment options.

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The role of hoof morphology is increasingly recognized as a factor associated with lameness incidence in performance horses. The primary objective was to evaluate effect of training initiation on hoof unevenness in Quarter Horses (n = 42; 29 2-year-olds, 13 3-year-olds) over 6-months (m) in training (m0, m2, m4, and m6). Horses were objectively assessed for lameness (inertial sensor system) and photographs and radiographs of feet were taken. Hoof measurements were taken (palmar/plantar angles, frog base width/length, toe length/angle, heel length/angle, heel/foot width, wall height/angle), and analyzed with regards to laterality. Front and hindfoot pairs were determined even if toe angles were within 1.5°. Statistical analyses were performed (Fisher's exact test, mixed-model linear regression, P < .05). There were no differences in distal phalanx palmar/plantar angle between lame/nonlame forelimbs (P = .54) or hindlimbs (P = .20). Unevenness between front feet was seen in toe angle m6 (P < .001), heel length m6 (P = .01) and heel angle over time (P = .006). Unevenness between hind feet was seen at m6 in toe angle (P < .001), heel length (P = .009) and heel angle (P = .02). Lameness incidence did not differ between even and uneven footed horses in forelimbs (P = .64) or hindlimbs (P = .09). In uneven feet, there was no difference in lameness between high versus low foot in forelimbs (P = .34) or hindlimbs (P = .29). Limitations include lack of control group not entering training, lack of consistency in timing data collection to previous trimming, and small sample size. In summary, differences in foot measurements and laterality were noted over time following training initiation in juvenile Western performance horses.

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Os indivíduos canhotos necessitam de utensílios para concretização de suas atividades diárias, bem como, para o exercício da prática odontológica onde a escassez de equipamentos específicos pode refletir em desgaste corporal, com isso, o presente trabalho tem por objetivo identificar os estudantes canhotos do curso de Odontologia da Universidade Federal de Uberlândia além de identificar suas dificuldades, queixas e locais de dores osteomusculares nas atividades laboratoriais e clínicas. Métodos: Foram incluídos todos os alunos canhotos matriculados no ano de 2021. Foram aplicados questionários on line para coletar os dados dos alunos. Resultados: Foram tabulados e como resultados, encontrou-se que os canhotos representam 5,6% do total de alunos do curso de Odontologia, a maioria são mulheres (66,7%), com média de idade de 21 anos. O segundo período foi o que apresentou maior número de canhotos (25%). As atividades práticas do curso, estas foram cursadas por 91,7% dos entrevistados, que relataram com maior frequência usar a mão esquerda (62,5%), sentar na posição de 1 hora (20,8%) e ter maior dificuldade ao tratar o quadrante superior direito (45,8%). Os locais mais citados de dores osteomusculares após realizar essas atividades, foram: punhos e mãos (62,5%), parte inferior das costas (62,5%) e pescoço (58,3%). Conclusão: Os canhotos representam a minoria dos alunos e suas dificuldades são, a falta de estrutura física adequada e a incompreensão das pessoas ao redor. Em relação a queixa de dor ou desconforto, mãos, punhos, parte inferior das costas e pescoço foram os membros mais citados no estudo(AU)

Left-handed individuals need tools to carry out their daily activities, as well as for the exercise of dental practice where the scarcity of specific equipment can reflect on body wear, with this, the present work aims to identify left-handed students of the course of Dentistry at the Federal University of Uberlândia, in addition to identifying their difficulties, complaints and sites of musculoskeletal pain in laboratory and clinical activities. Methods: All left-handed students enrolled in the year 2021 were included, and three questionnaires were applied online to identify the profile of students and the difficulties encountered in laboratory and clinical practice. Results: They were tabulated and as a result, it was found that left-handers represent 5.6% of the total number of students in the Dentistry course, most of them are women (66.7%), with a mean age of 21 years. The second period was the one with the highest number of left-handers (25%). The practical activities of the course were carried out by 91.7% of the interviewees, who reported more frequently using their left hand (62.5%), sitting in the 1 o'clock position (20.8%) and having greater difficulty when treat the upper right quadrant (45.8%). The most cited sites of musculoskeletal pain after performing these activities were: wrists and hands (62.5%), lower back (62.5%) and neck (58.3%). Conclusion: Lefthanded people represent the minority of students, and their difficulties are the lack of adequate physical structure and the misunderstanding of the people around them. In relation to complaints of pain or discomfort, hands, wrists, lower back and neck were the most cited members in the study(AU)

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El proyecto "Estudio de patrones de lateralidad de atletas elites de Cuba" tiene como objetivo el diagnóstico, la caracterización y la valoración de los patrones de lateralidad de atletas activos y retirados con altos resultados deportivos, pero hasta el momento se adolece de una profundización en la utilidad que puede tener la lateralidad en la preparación técnico-táctica en los deportes de combate, por lo que el objetivo de este artículo fue sistematizar las principales investigaciones relacionadas con la utilización de la lateralidad en estos deportes. Para ello, se emplearon los métodos inductivo-deductivo, análisis-síntesis y revisión bibliográfica con el fin de determinar los antecedentes e interpretar las principales investigaciones referentes sobre esta temática. Se concluyó que entre los principales aspectos abordados estuvieron: las ventajas competitivas de los deportistas zurdos, el volumen técnico que se realizó en competiciones, la caracterización del deportista de acuerdo a sus preferencias laterales y cómo estas influyen en el rendimiento deportivo. Sin embargo, no se apreció estudio alguno referido a la utilización de los patrones de la lateralidad en la preparación técnico-táctica en los deportes de combate, lo que devino en carencia, para el estudio de estas disciplinas deportivas.

O projeto "Estudo dos padrões de lateralidade de atletas de elite em Cuba" tem como objetivo diagnosticar, caracterizar e avaliar os padrões de lateralidade de atletas ativos e aposentados com altos resultados esportivos, mas até agora não houve um estudo aprofundado da utilidade que a lateralidade pode ter na preparação técnico-táctica em esportes de combate, portanto o objetivo deste artigo foi sistematizar as principais pesquisas relacionadas com o uso da lateralidade nestes esportes. Para este fim, foram utilizados os métodos indutivo-deducativo, análise-síntese e revisão bibliográfica a fim de determinar os antecedentes e interpretar as principais pesquisas sobre este assunto. Concluiu-se que entre os principais aspectos abordados estavam: as vantagens competitivas dos atletas canhotos, o volume técnico realizado nas competições, a caracterização do atleta de acordo com suas preferências laterais e como estas influenciam o desempenho esportivo. Entretanto, não foi encontrado nenhum estudo sobre o uso de padrões de lateralidade na preparação técnico-táctica em esportes de combate, o que resultou em uma falta de estudo destas disciplinas esportivas.

The project "Study of laterality patterns of elite athletes in Cuba" has as its objective the diagnosis, characterization and assessment of laterality patterns of active and retired athletes with high sports results, but so far it lacks a deepening in the usefulness that laterality can have in the technical-tactical preparation in combat sports, so the objective of this article was to systematize the main researches related to the use of laterality in these sports. For this, the inductive-deductive, analysis-synthesis and bibliographic review methods were used in order to determine the background and interpret the main reference research on this subject. It was concluded that among the main aspects addressed were: the competitive advantages of left-handed athletes, the technical volume that was carried out in competitions, the characterization of the athlete according to their lateral preferences and how they influence sports performance. However, no study was observed regarding the use of laterality patterns in technical-tactical preparation in combat sports, which became a lack, for the study of these sports disciplines.

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BACKGROUND: Parkinson's disease (PD) is characterized by a progressive loss of nigrostriatal dopaminergic neurons with impaired motor and non-motor symptoms. It has been suggested that motor asymmetry could be caused due to an imbalance in dopamine levels, as visualized by dopamine transporter single emission computed tomography test (DAT-SPECT), which might be related to indirect measures of neurodegeneration, evaluated by the Montreal Cognitive Assessment (MOCA) and α-synuclein levels in the cerebrospinal fluid (CSF). Therefore, this study aimed to understand the correlation between disease laterality, DAT-SPECT, cognition, and α-synuclein levels in PD. METHODS: A total of 28 patients in the moderate-advanced stage of PD were subjected to neurological evaluation, TRODAT-1-SPECT/CT imaging, MOCA, and quantification of the levels of α-synuclein. RESULTS: We found that α-synuclein in the CSF was correlated with global cognition (positive correlation, r2 = 0.3, p = 0.05) and DAT-SPECT concentration in the putamen (positive correlation, r2 = 0.4, p = 0.005), and striatum (positive correlation, r2 = 0.2, p = 0.03), thus working as a neurodegenerative biomarker. No other correlations were found between DAT-SPECT, CSF α-synuclein, and cognition, thus suggesting that they may be lost with disease progression. CONCLUSIONS: Our data highlight the importance of understanding the dysfunction of the dopaminergic system in the basal ganglia and its complex interactions in modulating cognition.

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Abstract In dentistry, most equipment is designed for right-handed (RH) individuals. Thus, left-handed (LH) individuals are often forced to adapt to demanding RH working conditions, and therefore, experience difficulties in their practice. The objective of this study was to determine the prevalence of left handedness among dental students at the Dental Clinic of Monastir, Tunisia, and to investigate the difficulties for LH individuals during clinical practice. A cross-sectional study was conducted among dental students during the academic year from September 2019 to March 2020. An adaptation of the Grad-Corllet Diagram and a specific questionnaire on clinical practices were administered to 221 participants. Data were analyzed using SPSS 24.0 statistical software for descriptive statistics and the chi-square test was performed (with a 5% significance level). The study revealed that 18.1% of dental students were LH. Among which, 82.5% of LH students had difficulties using instruments designed for RH dentists, 47.5% of LH students preferred the 3 o'clock working position, and 77.5% of LH students preferred to work in a sitting position. Most LH students (70%) reported that endodontic treatment was the most difficult procedure to perform. All students, whether RH or LH, presented a higher percentage of pain in the lumbar and neck/cervical regions; however, LH students presented higher values (77.5%) with statistically significant differences being reported for lower back pain (p = 0.026) and neck pain (p = 0.012). This study highlights the difficulties that LH dental students face in performing dental work. Dental Schools should provide LH students with appropriate equipment and a proper learning environment.

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Objetivo: este estudo buscou averiguar a possível discrepância bilateral de indicadores antropométricos de pessoas com e sem síndrome de Down (SD). Material e Método: para tal, contou-se com a participação de 60 indivíduos com e sem síndrome de Down, com idades entre 11 e 14 anos, que foram avaliados quanto à dominância lateral, dobras cutâneas, percentual de gordura, circunferência muscular de braço e antebraço e força de preensão palmar. Principais resultados: notou-se maior número de indivíduos sinistros e com indefinição na lateralidade no grupo com síndrome de Down do que nas pessoas com desenvolvimento típico. Os valores da percentagem de gordura, das medidas de dobra cutânea, da circunferência muscular do braço e da circunferência de antebraço foram maiores entre os participantes com síndrome de Down do que entre os do grupo controle. A força de preensão palmar foi maior nos indivíduos típicos. Não houve diferença na composição corporal bilateral dos indivíduos com síndrome de Down. Conclusão: os resultados encontrados demonstraram a existência de uma simetria bilateral nos indivíduos com e sem síndrome de Down.

Objective: this study sought to investigate the possible discrepancy in the bilateral anthropometric indicators of people with and without Down syndrome (DS). Material and Method: 60 individuals with and without Down syndrome, aged between 11 and 14 years, who were evaluated for lateral dominance, skinfolds, fat percentage, arm and forearm muscle circumference, and hand grip strength. Main results: there were a greater number of sinister individuals with a vagueness in laterality in the group with Down syndrome than in people with typical development. The percentage of fat, skinfold measurements, arm muscle circumference and forearm circumference were higher among participants with Down syndrome than those in the control group. Hand grip strength was greater in typical individuals. There was no difference in the bilateral body composition of individuals with Down syndrome. Conclusion: the results found demonstrated the existence of a bilateral symmetry in individuals with and without Down syndrome.

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Transcultural approaches comparing the distribution of lateral preference between countries focused primarily on handedness. However, other laterality dimensions may also be susceptible to cultural variations. The present study compared lateral preference in five dimensions (hand, foot, trunk, hearing, and visual) of young adults from Brazil and Mozambique. Two hundred and two undergraduate students participated in the study, of which 101 were Brazilian (21.7 ± 1.66 years old) and 101 Mozambican (25.6 ± 6.2 years old). The participants' lateral preference direction and degree were assessed using the global lateral preference inventory. Most Brazilians were classified in the moderate preference category, while Mozambicans had a higher frequency of individuals with strong preferences. Hence, Mozambicans presented a higher lateralization degree for all dimensions. A subsequent analysis considering only preference direction (right, left or indifferent), and not degree, did not show the same outcomes, revealing similarities in preference distribution between the two groups. This finding highlights the necessity to incorporate preference degrees in future analysis to not overlook potential differences. We also conclude lateral preference investigations with transcultural approaches should analyse beyond handedness, as other dimensions can also be modulated by cultural characteristics.

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La lateralización, al ser la preferencia motriz de un lado del cuerpo sobre el otro, tiene aplicaciones prácticas en los deportes, pues el control y potenciación del lado diestro y no diestro requieren de análisis previos y de estrategias específicas de desarrollo. En tal sentido, y como primer paso de la investigación, se propone como objetivo validar teóricamente a través de especialistas nacionales e internacionales una propuesta de indicadores de lateralidad a tener en cuenta en el entrenamiento del dribling del baloncesto de iniciación. La investigación es teórica-descriptiva, de orden correlacional y análisis cualitativo, estudiando los criterios teóricos emitidos por 13 especialistas nacionales de baloncesto (Grupo 1) y diez especialistas extranjeros (Grupo 2). De los nueve indicadores analizados, en seis existieron diferencias significativas en los criterios emitidos por cada grupo independiente (LV: p=0.000; LH: p=0.000; LC: p=0.002; Pdi: p=0.000; PE: p=0.000 y ME: p=0.001), con excepción de la mano dinámica (Mdi: p=0.648), mano director (MD: p=0.738) y el indicador mano no director (MnD: p=0.605). Todos los rangos promedios emitidos por los especialistas internacionales fueron mayores que en los especialistas nacionales, indicativo de que los primeros consideran de mayor importancia el entrenamiento de diversos indicadores de lateralidad en el dribling del baloncesto de iniciación. En tal sentido, se recomienda realizar un trabajo metodológico con los especialistas nacionales en función de mejorar la comprensión sobre la importancia del entrenamiento de la lateralidad en todas sus manifestaciones, especificando aspectos relacionados con el entrenamiento técnico y técnico-táctico, incluyendo el dribling como técnica fundamental.

A lateralizarão, sendo a preferência motora de um lado do corpo sobre o outro, tem aplicações práticas no esporte, já que o controle e a capacitação do lado direito e do lado não direito exigem análise prévia e estratégias específicas de desenvolvimento. Neste sentido, e como primeiro passo da pesquisa, propõe-se como objetivo validar teoricamente através de especialistas nacionais e internacionais uma proposta de indicadores de lateralidade para levar em conta no treinamento de drible no basquetebol introdutório. A pesquisa é descritiva teórica, de ordem correlacional e análise qualitativa, estudando os critérios teóricos emitidos por 13 especialistas nacionais em basquetebol (Grupo 1) e dez especialistas estrangeiros (Grupo 2). Dos nove indicadores analisados, em 6 houve diferenças significativas nos critérios emitidos por cada grupo independente (LV: p=0,000; LH: p=0,000; LC: p=0,002; Pdi: p=0,000; PE: p=0,000 e ME: p=0,001), com exceção da Mão Dinâmica (Mdi: p=0,648), mão direcionadora (MD: p=0,738) e do indicador de mão não direcionadora (MnD: p=0,605). Todas as faixas médias emitidas pelos especialistas internacionais foram superiores às dos especialistas nacionais, indicando que os primeiros consideram de maior importância o treinamento de vários indicadores de lateralidade no drible no basquetebol introdutório. Neste sentido, recomenda-se realizar um trabalho metodológico com especialistas nacionais a fim de melhorar a compreensão da importância do treinamento da lateralidade em todas as suas manifestações, especificando aspectos relacionados ao treinamento técnico e técnico-táctico, incluindo o drible como técnica fundamental.

Lateralization, being the motor preference of one side of the body over the other, has practical applications in sports, since the control and empowerment of the right-handed and non-right-handed side require previous analysis and specific development strategies. In this sense, and as a first step of the research, it is proposed as an objective to validate theoretically through national and international specialists a proposal of laterality indicators to be taken into account in the training of dribbling in initiation basketball. The research is theoretical-descriptive, of correlational order and qualitative analysis, studying the theoretical criteria issued by 13 national basketball specialists (Group 1) and ten foreign specialists (Group 2). Of the nine indicators analyzed, in 6 there were significant differences in the criteria issued by each independent group (LV: p=0.000; LH: p=0.000; LC: p=0.002; Pdi: p=0.000; PE: p=0.000 and ME: p=0.001), with the exception of the Dynamic Hand (Mdi: p=0.648), director hand (MD: p=0.738) and the non-director hand indicator (MnD: p=0.605). All the average ranges issued by the international specialists were higher than in the national specialists, indicating that the former consider of greater importance the training of various indicators of laterality in the dribbling of initiation basketball. In this sense, it is recommended to carry out methodological work with national specialists in order to improve the understanding of the importance of laterality training in all its manifestations, specifying aspects related to technical and technical-tactical training, including dribbling as a fundamental technique.

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The aim of this study was to determine paired asymmetries (right-left) in the autopods of bovine hindlimbs using geometric morphometry (GM). A total of 28 hindlimb right-left matched autopods belonging to healthy Brown Pyrenean calves were assessed. Dorsoplantar radiographs were obtained for each autopod. The bone shape was compared on right and left pairs by means of GM techniques, using a set of 15 landmarks. The results suggest that right and left distal limbs are, despite a perceived resemblance of symmetry, differently directionally developed in shape, with right hindlimbs tending to supinate (rotate outwards) and left hindlimbs tending to pronate (rotate inwards). This unevenness is probably related to the mediolateral forces' contribution of each limb in carrying out the tasks of propulsion and control during walking, and/or a consequence of a laterality associated with a lateralized grazing posture. Our findings prompt a new reassessment of the function of each bovine hindlimb during standing and locomotion.

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ABSTRACT: This work aims to verify the effectiveness of the semi-adjustable articulator (SAA) when compared to a clinical examination of samples in individuals comparing the number of occlusal interferences. The research was carried out at FAESA (Integrated University of São Pedro), in which two independent researchers compared occlusal interferences in protrusion and laterality movements in the clinical examination and in models mounted on a semi-adjustable articulator, with carbon from Baush, in 77 patients who attended to the graduation clinic. Data were tabulated and evaluated by the Mann- Whitney statistical test and data normality was verified by the Kolmogorov-Smirnov test. When analyzing the interference of protrusion on central incisors, it was found that the mean was higher for the SAA on clinical examination. As for the right laterality in the canine guides, it was observed that the clinical examination had a higher interference average in relation to the SAA. The same was true for left laterality, where the mean interference was also higher for the clinical examination. That is, by increasing the values of occlusions in the SAA, the values of occlusions in the clinical examination also increase. As central incisor protrusions between the SAA and clinical examination were moderately positive, there was a strong positive relationship for the right sides and a moderate positive relationship for the left sides. It is concluded that a semi-adjustable articulator is an effective tool for the diagnosis and planning of the dentist, due to its ability to simulate mandibular movements. However, such a tool requires prior knowledge for an ideal assembly for treatment success.

RESUMEN: Este trabajo tuvo como objetivo verificar la efectividad del articulador semi-ajustable (SAA) cuando se compara con un examen clínico de muestras en individuos de acuerdo al número de interferencias oclusales. La investigación se llevó a cabo en FAESA (Universidad Integrada de São Pedro), en la que dos investigadores independientes compararon las interferencias oclusales en los movimientos de protrusión y lateralidad en el examen clínico y en modelos montados en un articulador semiajustable, con carbón de Baush, en 77 pacientes que acudieron a la clínica de graduación. Los datos se tabularon y evaluaron mediante la prueba estadística de Mann-Whitney y la normalidad de los datos se verificó mediante la prueba de Kolmogorov-Smirnov. Al analizar la interferencia de la protrusión en los incisivos centrales, se encontró que la media era mayor para el SAA en el examen clínico. En cuanto a la lateralidad derecha en las guías caninas, se observó que el examen clínico tuvo un promedio de interferencia más alto en relación al SAA. Lo mismo ocurrió con la lateralidad izquierda, donde la interferencia media también fue mayor para el examen clínico. Es decir, al aumentar los valores de oclusiones en el SAA, también aumentan los valores de oclusiones en el examen clínico. Como las protuberancias de los incisivos centrales entre el SAA y el examen clínico fueron moderadamente positivas, hubo una fuerte relación positiva para los lados derechos y una relación positiva moderada para los lados izquierdos. Se concluye que un articulador semi-ajustable es una herramienta eficaz para el diagnóstico y planificación del odontólogo, debido a su capacidad para simular movimientos mandibulares. Sin embargo, tal herramienta requiere conocimientos previos para un montaje ideal para el éxito del tratamiento.

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BACKGROUND: During embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast tumors exhibit consistently-biased incidence, gene expression, and DNA methylation. We postulate that a differential L/R tumor-microenvironment crosstalk generates different tumorigenesis mechanisms. METHODS: We performed in-silico analyses on breast tumors of public datasets, developed xenografted tumors, and conditioned MDA-MB-231 cells with L/R mammary extracts. RESULTS: We found L/R differential DNA methylation involved in embryogenic and neuron-like functions. Focusing on ion-channels, we discovered significant L/R epigenetic and bioelectric differences. Specifically, L-sided cells presented increased methylation of hyperpolarizing ion channel genes and increased Ca2+ concentration and depolarized membrane potential, compared to R-ones. Functional consequences were associated with increased proliferation in left tumors, assessed by KI67 expression and mitotic count. CONCLUSIONS: Our findings reveal considerable L/R asymmetry in cancer processes, and suggest specific L/R epigenetic and bioelectric differences as future targets for cancer therapeutic approaches in the breast and many other paired organs.

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BACKGROUND: Orthopedic surgeons experience significant musculoskeletal pain and work-related injuries while performing total joint arthroplasty (TJA). We sought to investigate the impact of operative extremity and surgeon limb dominance on surgeon physiologic stress and energy expenditure during TJA. METHODS: This was a prospective cohort study conducted at a tertiary academic practice. Cardiorespiratory data was recorded continuously in 3 high-volume arthroplasty surgeons using a smart garment that measured heart rate (HR), HR variability, respiratory rate, minute ventilation, and energy expenditure (calories) during conventional total knee (TKA) and total hip arthroplasty (THA). RESULTS: Surgeon 1 and 2 (right-handed) performed 21 right TKAs, 10 left TKAs, 13 right THAs, and 10 left THAs. Surgeon 3 (left-handed) performed 6 right TKAs, 9 left TKAs, 16 right THAs, and 10 left THAs. While performing TKA or THA, limb laterality had no significant impact on operative time and no significant differences existed in HR, HR variability, respiratory rate, minute ventilation, or energy expenditure for any right-handed or left-handed surgeons, regardless of the operative limb laterality. While performing TKA, consistently standing on the side of hand dominance was associated with decreased strain and stress, compared to always standing on the operative side. CONCLUSION: This study suggests that surgeon hand dominance and operative limb laterality do not impact energy expenditure or physiologic strain during TJA. However, consistently standing on the side of hand dominance in TKA may lead to decreased physiologic strain and stress during surgery. Further study utilizing wearable technology during TJA may provide orthopedic surgeons with information about modifiable factors that contribute to differences in physiological parameters during surgery.

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O objetivo deste estudo foi apresentar dados normativos para o TFMJT para a população brasileira. Participaram do estudo 360 pessoas, entre 06 e 49 anos, divididas em seis grupos por faixa etária, sendo 178 do sexo masculino e 182 do sexo feminino. Os dados foram apresentados separadamente para as diferentes faixas etárias, para sexo masculino e feminino. Os valores referentes às médias e ao desvio padrão foram calculados para cada uma das sete tarefas, considerando mão dominante e mão não dominante. Observou-se desempenho superior para mão dominante, com diferença significante para a soma das sete tarefas, em ambos os sexos (p=0,001). Os resultados obtidos poderão servir de parâmetros de referência para a população brasileira e contribuir para avaliações quantitativas do desempenho manual em programas de avaliação ou reabilitação do membro superior.

The aim of this study was to present normative data for the JTHF for the Brazilian population. Participated 360 individuals between 06 and 49 years old, divided into six groups by age, being 178 males and 182 females. The data were presented separately for the different age groups, for men and women. Values for means and standard deviation were calculated for each of the seven tasks, considering dominant and non-dominant hands. Superior performance was observed for the dominant hand, with a significant difference for the sum of the seven tasks, in both sexes (p = 0.001). The results obtained is a reference parameter for the Brazilian population and contribute to quantitative assessments of manual performance in programs of assessment or rehabilitation of the upper limb.