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Objective:To explore the application value of neuroendoscopic Endoport technique in resection of intracranial lesions involving the interventricular foramen.Methods:A retrospective analysis was performed; 21 patients with intracranial lesions involving the interventricular foramina accepted treatment by neuroendoscopic Endoport technique in our hospital from January 2018 to August 2020 were chosen. The surgical results and prognoses at follow-up were discussed.Results:In these 21 patients, total removal of the lesions was achieved in 19 patients, and subtotal removal in 2 patients; perioperative complications included 1 patient with postoperative hemorrhage and 1 patient with intracranial infection. During the follow-up of 3-30 months, except for 1 patient lost of follow-up, Karnofsky performance scale scores at the last follow-up were 85.5±3.5, and no signs of tumor recurrence were found during the imaging follow-up.Conclusion:Neuroendoscopic Endoport technique can help to safely and effectively remove intracranial lesions involving the interventricular foramen, and the patients enjoy good prognosis.
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BACKGROUND: Rat developmental toxicity including embryolethality and teratogenicity (mainly ventricular septal defects [VSDs] and wavy ribs) was produced by an N-phenylimide herbicide that inhibits protoporphyrinogen oxidase (PPO) common to chlorophyll and heme biosynthesis. Major characteristics of the developmental toxicity included species difference between rats and rabbits, compound-specific difference among structurally similar herbicides, and sensitive period. Protoporphyrin accumulation in treated fetuses closely correlated with the major characteristics. Iron deposits in erythroblastic mitochondria and degeneration of erythroblasts were observed in treated rat fetuses. In this study we investigated fetal anemia and subsequent developmental effects in rats, and inhibition of PPO in rats, rabbits, and humans by the herbicides in vitro. METHODS: Fetuses were treated on gestational day (GD) 12 and removed on GDs 13 through 20. All litters were examined externally. One half of litters were examined for blood and skeletal development, and the other half for interventricular foramen closure. Effects on PPO were determined in mitochondria from embryos and adult livers. RESULTS: Fetal anemia in rats was evident on GDs 13 through 16. Subsequently, enlarged heart, delayed closure of the foramen, reduced serum protein, and retarded rib ossification were observed. In vitro PPO inhibition exhibited species- and compound-specific differences corresponding to the developmental toxicity. CONCLUSION: We propose that developmental toxicity results from PPO inhibition in primitive erythroblasts, causing transient fetal anemia followed by death. Compensatory enlargement of the fetal heart results in failure of interventricular foramen closure and VSD. Reduced serum protein leads to delayed ossification and wavy ribs.
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Anemia/embriología , Anemia/patología , Feto/anomalías , Feto/embriología , Herbicidas/toxicidad , Imidas/toxicidad , Animales , Benzoxazinas/farmacología , Proteínas Sanguíneas/metabolismo , Recuento de Eritrocitos , Femenino , Mortalidad Fetal , Feto/efectos de los fármacos , Feto/patología , Corazón/efectos de los fármacos , Corazón/embriología , Hemo/biosíntesis , Hemoglobinas/metabolismo , Herbicidas/química , Humanos , Imidas/química , Concentración 50 Inhibidora , Ftalimidas/farmacología , Embarazo , Protoporfirinógeno-Oxidasa/antagonistas & inhibidores , Protoporfirinógeno-Oxidasa/metabolismo , Conejos , Ratas Sprague-Dawley , Costillas/anomalías , Costillas/embriología , Especificidad de la EspecieRESUMEN
OBJECTIVES: Lesions around interventricular foramen are difficult to remove for their important adjacent structures. We classify these tumors according their location on Magnetic Resonance Image (MRI) to help us resect these lesions. METHODS: Thirty-two tumors around the interventricular foramen were studied according their location and anatomic relations in MRI. RESULTS: Tumors around interventricular foramen were classified into three types. The first one mainly locates in lateral ventricle and the second one growth both in lateral ventricle, interventricular foramen and third ventricle, while the third one mainly in third ventricle. Different surgical approaches were adopted according their classification and the patients recovered well. CONCLUSION: This classification can help us to chose the surgical approach for these tumors.
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Encéfalo/patología , Neoplasias del Ventrículo Cerebral/patología , Tercer Ventrículo/patología , Adolescente , Adulto , Encéfalo/cirugía , Neoplasias del Ventrículo Cerebral/cirugía , Niño , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos/métodos , Tercer Ventrículo/cirugía , Resultado del Tratamiento , Adulto JovenRESUMEN
Amongst the contributions in anatomy and surgery of the celebrated Monros was the contentious "discovery" by Monro Secundus of the interventricular foramen. Monro's account (1783) was vehemently criticized in London, especially by Charles Bell for presuming to describe something which was already well known and for inaccuracies. Monro with some justification in 1797 disputed this attack, although his anatomical description was shown by later anatomists to be mistaken.
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Anatomía/historia , Ventrículos Cerebrales/anatomía & histología , Inglaterra , Historia del Siglo XVIII , Historia del Siglo XIX , EscociaRESUMEN
Objective To study the clinical application anatomy of interventricular foramen and offer a base for operation.Methods Interventricular foramens were observed in 15 adult cadaveric brainThirty- two patients of obstructive hydrocephalus were operated to observe the structure of interventricular foramen un- der neuroendoscope.Results Interventricular foramen was a poriform structure which consists of fornixan- terior pole of thalamencephalon and choroid plexus and was a oval shape in most of themThe plane of the fo- ramen was a included angle with the median sagittal planeThe septal veinthalamostriate veinthalamen- cephal and even the floor of third ventricle could be observed clearly in endoscope.At the same timewe found the foramen had a significant change in obstructive hydrocephalus.Conclusion The interventricular foramen has a simple relatively structure but a variation on size and shape especially in obstructive hydroceph- alusA clearly comprehension of it's structure and adjacent is a base to microsurgery and endoscopic surgery on the foramen.