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The illegal trade in totoaba (Totoaba macdonaldi) is causing adverse social, ecological, and economic impacts. This illegal activity is accelerating the overexploitation of totoaba and pushing the critically endangered vaquita (Phocoena sinus) closer to extinction. Despite extensive efforts to recover vaquita populations, scant attention has been given to the totoaba trade as an independent issue. As a result, data on the totoaba trade are limited, which hampers robust analyses and development of effective interventions to reduce illegal harvesting. We used a previously developed framework specifically designed to examine dynamics of illegal markets and guide measures to mitigate illegal use of totoaba. This framework separates markets into 3 analytical levels: characterization of participating actors (e.g., fishers, intermediaries); examination of how actors interact within the market (e.g., organization of supply chains); and assessment of the overall market dynamics that result from these interactions (e.g., factors determining price and quantity). We reviewed existing literature (108 initial articles) and interviewed key market actors, academics, and nongovernmental organization experts (14) to obtain data for this framework. Our findings offer an overview of the totoaba illegal market operation, highlighting intervention points (e.g., customs agents) and areas where additional information is required to decrease information gaps (e.g., US local market). We describe the structure and complexity of this market, emphasizing the influential role of organized crime in shaping its dynamics (e.g., controlling prices paid to fishers and stockpiling). By providing a systematic and in-depth understanding of the market operation, we aimed to establish a benchmark for effective interventions and future research aimed at reducing uncertainties. Our results provide a crucial step toward addressing this critical issue and can help facilitate development of effective strategies to combat the illegal totoaba trade and promote biodiversity conservation more broadly.

Evaluación de las intervenciones potenciales para reducir el mercado ilegal de la totoaba Resumen El mercado ilegal de totoaba (Totoaba macdonaldi) causa impactos sociales, ecológicos y económicos adversos. Esta actividad ilegal acelera la sobreexplotación de la totoaba y acerca a la extinción a la vaquita marina (Phocoena sinus), especie en peligro crítico de extinción. A pesar de los grandes esfuerzos por recuperar las poblaciones de vaquita, el comercio de totoaba recibe poca atención como problema independiente. Como resultado, los datos sobre este comercio son limitados, lo que dificulta el análisis sólido y el desarrollo de intervenciones eficaces para reducir la captura ilegal. Utilizamos un marco desarrollado previamente y diseñado específicamente para examinar la dinámica de los mercados ilegales y orientar las medidas para mitigar el uso ilegal de la totoaba. Este marco separa los mercados en tres niveles analíticos: caracterización de los actores participantes (por ejemplo, pescadores, intermediarios); análisis de cómo interactúan los actores dentro del mercado (por ejemplo, organización de las cadenas de suministro); y evaluación de la dinámica general del mercado que resulta de estas interacciones (por ejemplo, factores que determinan el precio y la cantidad). Revisamos la bibliografía existente (108 artículos iniciales) y entrevistamos a actores clave del mercado, académicos y expertos de organizaciones no gubernamentales (14) para obtener datos para este marco. Nuestras conclusiones ofrecen una visión general del funcionamiento del mercado ilegal de totoaba y destacan los puntos de intervención (por ejemplo, los agentes aduanales) y las áreas en las que se requiere información adicional para reducir los vacíos informativos (por ejemplo, el mercado local estadunidense). Describimos la estructura y complejidad de este mercado, destacando el influyente papel de la delincuencia organizada en la configuración de su dinámica (por ejemplo, controlando los precios pagados a los pescadores y el almacenamiento). Al proporcionar una comprensión sistemática y en profundidad del funcionamiento del mercado, pretendemos establecer un punto de referencia para intervenciones eficaces y futuras investigaciones encaminadas a reducir las incertidumbres. Nuestros resultados suponen un paso crucial para abordar esta cuestión crítica y pueden ayudar a facilitar el desarrollo de estrategias eficaces para combatir el comercio ilegal de totoaba y promover la conservación de la biodiversidad de forma más amplia.

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The emergence and evolution of engineering biology, and its potential to address multiple global challenges is associated with the rise of biofoundries. These innovation intermediaries are facilities that employ advanced automation and computational analytics to accelerate engineering biology applications. Yet, for biofoundries to fully achieve their promise of generating applications that address grand societal challenges, they need to meet three key challenges: translation of research technology and its commercialization, attention to sustainability, and responsible innovation. Using web content analysis and interviews, this paper explores the functions and capabilities undertaken by existing public biofoundries, the extent to which they address these three challenges, and opportunities and models for enhancement. We also probe the roles undertaken by three other contrasting types of innovation intermediaries to identify practices and opportunities for integration and partnering with public biofoundries. We find that public biofoundries exhibit relatively strong capabilities for research translation, whereas efforts toward sustainability and responsibility are generally less prominent. For biofoundry enhancement, we propose an organisational model based on external partnering where public biofoundries are positioned as intermediaries within regional innovation systems. The framework put forward is reproducible and could be used in other contexts for assessing innovation intermediary organisational functions and capabilities toward meeting societal challenges.

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BACKGROUND: In the Netherlands, neighborhood sport coaches (NSCs) play an important role as intermediaries in promoting physical activity (PA) in the neighborhood. Gamification is the use of game elements in nongame contexts; it can be implemented with or without technology and holds promise for promoting PA. NSCs infrequently make use of this option. OBJECTIVE: This study aims to understand barriers to, and facilitators of, using gamification to promote PA, as perceived by NSCs. METHODS: A total of 25 semistructured interviews were conducted with NSCs in the Netherlands. The interviews were audiotaped, transcribed, and analyzed by means of thematic analysis using ATLAS.ti (version 22; ATLAS.ti Scientific Software Development GmbH) software. The deductive coding was informed by the capability, opportunity, motivation, behavior model and the theoretical domains framework, complemented by inductive coding. RESULTS: Barriers and facilitators identified as factors influencing the implementation of gamification were related to 7 themes. NSCs required technical, creative, and promotion skills; knowledge about existing gamification tools; and social support from their employer and professional network. Financial costs were identified as a barrier to the successful implementation of gamification. Lack of clarity regarding stakeholders' responsibility to implement gamification could further hamper implementation. In general, NSCs were positive about investing time in implementing gamification and expected positive effects from implementing it. CONCLUSIONS: To overcome identified barriers, a clear overview of tools, best practices, and available subsidies must be created, a gamification network must be established, the responsibility of NSCs must be clarified, and guidance must be offered on the promotion of gamification.

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Background: Intermediaries are health-related workers who facilitate connections to local physical activities. Intermediaries deliver interventions by receiving referrals, conducting assessments, connecting referred individuals to activities and/or services in the community, and following up with them over time. However, it is unclear whether individuals who are referred to physical activities by an intermediary improve their physical activity levels, and what their perspectives and experiences are of participating in this intervention. To date there has been a lack of studies investigating the effect of this intervention on physical activity using appropriate outcome measures. Methods: This will be a mixed methods pilot feasibility study. Participants will be individuals referred or self-referred to an intermediary and connected to local physical activities. Participants will be recruited through two types of intermediary services in Ireland; social prescribing and local sports partnerships. A total of 30 participants will be recruited (15 per service). Baseline demographic information will be taken upon enrolment to the study and three questionnaires will be completed: the International Physical Activity Questionnaire - Short Form, Self-Efficacy for Exercise Scale and Short Warwick Edinburgh Mental Well-being Scale. The questionnaires will be repeated after 12 weeks and in addition semi-structured interviews will be carried out to explore intervention content and delivery, as well as acceptability of the intervention and evaluation design. Discussion: This overall aim of this proposed study is to investigate the feasibility of an intervention delivered by an intermediary to improve physical activity and health-related outcomes of community-dwelling individuals. Registration: ClinicalTrials.gov (NCT06260995).

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The COVID-19 pandemic generated diverse impacts and responses in agricultural value chains worldwide. Cocoa is a key crop for Ecuadorian exports, and the analysis of effects the pandemic had on value chain actors contributes to the understanding of their individual capacities to coping with a major shock. The purpose of this study was to assess the number and severity of impacts and responses implemented by two links in the cocoa value chain to the pandemic, based on a survey of 158 cocoa farmers and 52 cocoa intermediaries from the main cocoa-producing provinces of the northern coast of Ecuador in 2021. Surveyed farmers and part of the intermediaries form part of the sustainability program of a large Swiss chocolate manufacturer. The impacts and responses reported were grouped into seven resources according to the Activity System Approach. Then, a comparison between groups was applied using the Wilcoxon rank sum test for nonparametric data, determining the most severe impacts and effective resilience responses among the actors. The results reveal that farmers and intermediaries were similarly affected by the pandemic, reporting 21 and 16 negative impacts, respectively. Farmers experienced a higher number and severity of impacts on financial and social resources, while intermediaries on human and material resources. The strongest impact was the loss of sales, reported by 65% of farmers and 58% of intermediaries. Farmers implemented more social responses that they judged highly effective, while intermediaries implemented more human responses that they judged highly effective. Public policy should enhance the social resources of farmers by strengthening their associativity and the capacities of their members, as mechanisms to mitigate their vulnerability to future health and climate crises. The financial resources of both actors should be protected through public credit and agricultural insurance.

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El facilitador es un profesional que posibilita el ejercicio del derecho de acceso a la justicia a las personas con discapacidad intelectual y del desarrollo, favoreciendo los principios de equidad, participación, accesibilidad y autodeterminación. En el presente estudio, se realiza una revisión bibliográfica para determinar la presencia de esta figura en el panorama internacional y su perfil formativo. En el derecho internacional, actualmente, podemos encontrarla en algunos países nórdicos, Reino Unido, Israel, Azerbaiyán, Taiwán, Sudáfrica, Kenia, Canadá, varios estados de EE. UU., México y Chile, así como en parte del territorio australiano y Nueva Zelanda. En España, la figura aparece en la última reforma de la legislación civil y procesal (Ley 8/2021, de 2 de junio). En su perfil formativo encontramos tanto la educación formal como no formal de estos profesionales. El perfil del facilitador habrá de ajustarse a las necesidades de las personas con discapacidad intelectual y del desarrollo y del contexto que requiera la facilitación. (AU)

Intermediaries are professionals who enable the effective right of access to justice for people with intellectual and developmental disabilities, ensuring principles of equity, participation, accessibility and self-determination for them. This paper analyzes the presence and formative background of this figure from an international comparative perspective. Nowadays, we can find these professionals in the international law across different countries: some Nordic countries, United Kingdom, Israel, Azerbaijan, Taiwan, South Africa, Kenya, Canada, part of the USA, Mexico and Chile, Australia and New Zealand. In Spain, intermediaries are considered in the latest reform of the civil and procedural legislation (Law 8/2021, June the 2nd). This paper analyzes the formative background of this figure from an international comparative perspective. We find both formal and non-formal education in the background of these professionals. There is no doubt their profile must adjust to the needs of people with intellectual and developmental disabilities and the contexts that require the facilitation. (AU)

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Intermediation and transformative capacity building are identified as important issues in sustainability transformations. Yet the connection of these two concepts has not been systematically analysed. This empirical, qualitative case study on active transport in Finland investigates intermediation in building local transformative capacity. The study shows that intermediaries are a heterogeneous group of actors that support transformative capacity building by facilitating the flows of knowledge, linking actors, forming ties across different scales, and supporting visioning and strategic planning. Intermediation manifests in five of the seven elements of local transformative capacity building. Our study, thus, contrasts with previous understanding wherein intermediation is considered only as a criterion for multiform governance. As intermediation is central in building transformative capacity, it should be better acknowledged, particularly by authorities and policymakers to secure legitimacy, operational capabilities, and funding for intermediaries.

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Background: Reporting on strategies to advance implementation outcomes is imperative. The current study reports descriptive information about external implementation support (EIS) provided over 5 years to 13 regions in North Carolina and South Carolina scaling an evidence-based system of parenting and family supports. Regional support teams operating through the Implementation Capacity for Triple P (ICTP) projects employed core practice components (CPCs) for EIS as proposed by Aldridge et al. and further operationalized by members of The Impact Center at FPG Child Development Institute, UNC-Chapel Hill. Method: Practice activities associated with CPCs were developed and iteratively refined across the study period. ICTP regional support teams systematically tracked their use of CPCs and related activities following each substantive support interaction. Tracking included the duration of time a CPC was employed and the use of specific practice activities associated with that CPC. Data were aggregated by month of the relationship to account for differential start dates across regions. Results: From November 2016 through December 2021, ICTP support teams tracked 749 support interactions with Triple P regions in North Carolina and South Carolina. Monthly support decreased year over year, though dose varied considerably. Patterns of CPC use indicated a high dose of "foundational" and "co-design" CPCs early, followed by a blended and more diverse use thereafter, with some notable trends. Practice activities considered essential to influencing intended practice outcomes were characterized by higher rates of use. Like CPCs, practice activities were used dynamically across the study period. Conclusions: This descriptive study offers a case study for how EIS might be operationalized, tracked, and employed. Findings suggest several interpretations that might refine our understanding and use of EIS. Although the nature of this practical report precludes generalizability of findings, directions for future research and practice are discussed.

More needs to be known about how external support providers work with organizational, system, and community partners to improve their efforts to implement innovative programs and practices. Although a handful of models of external support have emerged in the literature, support strategies or activities are not often tracked systematically or prospectively. In the current study, we report on the adoption, operationalization, and use of a recently proposed model of external support across 13 regions in North Carolina and South Carolina scaling an evidence-based system of parenting and family interventions. Teams of external support providers tracked their activities using the model across more than 5 years. Results provide a description of what external support might look like across long-term support engagements, noting key patterns about dose of support and use of activities that might be responsible for influencing intended support outcomes. The study offers several findings that might refine our understanding and use of external support strategies. In addition, the study lays groundwork for examining additional research questions, such as the feasibility of support processes and whether and how support activities influence support outcomes.

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Background: External implementation support (EIS) is a well-recognized feature of implementation science and practice, often under related terms such as technical assistance and implementation facilitation. Existing models of EIS have gaps related to addressing practice outcomes at both individual and organizational levels, connecting practice activities to intended outcomes, or grounding in well-established theories of behavior and organization change. Moreover, there have been calls to clarify the mechanisms of change through which EIS influences related outcomes. Method: In this article, we theorize about mechanisms of change within EIS. Our theorizing process aligns with the approach advocated by Kislov et al. We aim to consolidate prior EIS literature, combining related constructs from previous empirical and conceptual work while drawing on our extensive EIS experience to develop a higher-order, midrange theory of change. Results: Our theory of change is empirically and practically informed, conceptually situated within an established grand theory of change, and guided by eight practice principles and social cognitive theory. The theory of change proposes 10 core practice components as mechanisms of change within EIS. When used according to underlying theory and principles, they are believed to contribute to favorable practice outcomes at individual, team, organizational, and system levels. The model offers flexibility by recognizing the need for sequential support processes and the demand to practice in dynamic and responsive ways. Case examples are presented to illustrate major themes and patterns of the model in action. Conclusions: The proposed model is intended to support prospective EIS studies by conceptualizing discernable practice components with hypothesized relationships to proximal and distal practice outcomes. The model can be behaviorally operationalized to compliment and extend competency-based approaches to implementation support practitioner (ISP) training and coaching. Over time, the model should be refined based on new empirical findings and contributions from ISPs across the field.

There are few models that help us understand how external support providers work with organizational, system, and community partners to improve their efforts to implement innovative programs and practices. Existing models typically describe characteristics and features of the process but lack grounding in well-established theories of behavior and organizational change. In this paper, we theorize about mechanisms of change within the support process, which we label core practice components, and explain how their use might improve implementation efforts through shorter- and longer-term practice outcomes. We believe that our model holds promise for informing future advancements in both research and practice. Foremost, the core practice components lend themselves to behavioral definitions and thus being observed and reported in action. In research, this will allow the relationships we propose in our model to be tested and refined over time, resulting in an incremental accumulation of knowledge. In practice, a greater understanding of core practice components and their relationships to key practice outcomes offers ways to enhance training and coaching activities for external support providers. The model may also aid support providers to more effectively navigate the support process and plan more timely and effective support strategies.

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The increasing salience of sustainability concerns in financial markets has led to growing demand by financial institutions, regulatory authorities and other stakeholders for information on the Environmental, Social and Governance (ESG) credentials of companies. To address these demands, private firms providing ESG data and related products have expanded in size and in number. Reflecting the increased importance of ESG data, academics, sustainable finance practitioners and financial regulators have surveyed the emerging industry of these ESG information firms. However, to date no structured dataset on the characteristics of ESG information firms is available. The ESG Information Firms Dataset (ESGFiDa) presented in this article is a first step to address this gap. ESGFiDa consolidates the findings from the academic and gray literature on the ESG information industry and augments these with additional data gathered through desk research. Based on this multi-stage data collection process, the dataset provides 1) a meta-analysis of existing accounts of ESG information firms from a variety of sources and 2) consolidated and augmented data about 128 ESG information firms. The meta-analysis part of the dataset contains amongst others information on different estimates regarding the size of the ESG information industry that have been proposed in the literature. The second part of ESGFiDa provides data on 128 ESG information firms that have been identified from the literature and consists of five variables (Name, Type, Country, Continent, Year of incorporation, and Headquarters). In addition, mergers and acquisitions among the 128 ESG information firms are recorded in a dated and geolocated edgelist with 65 entries. These relational data can be used for network analysis. In summary, ESGFiDa offers a first systematized description of the dynamics of the emerging ESG information industry. As such, it can be of interest to students of sustainable finance from fields including finance and economics, political science, organization studies, sustainability studies and financial geography. Moreover, practitioners from financial institutions interested in the backgrounds and differences of ESG information firms as well as policymakers and financial regulators tasked with overseeing and regulating the emerging ESG information industry might find the presented dataset useful.

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Culture scholars have shown that cultural intermediaries play a crucial role in the reproduction of inequalities in consecration (Corse and Westervelt, 2002; Maguire Smith and Matthews, 2012; Miller, 2014; Ridgeway, 2011; Steinberg, 1990 cited in Bourdieu, 2010). However, the analysis of gender inequalities in reception and canonization has focused on individual bias, neglecting the contribution of scholars of hegemonic masculinity about the importance of patterned practices in the reproduction of men's dominance over women (Connell and Messerschmidt, 2005). Given that art worlds are not settings where typical markers of hegemonic masculinity are valued, such as money and physical prowess, what are the tools of hegemonic masculinity in art worlds? I answer this question through a comparative analysis of the reception of two iconic Canadian feminist novels: L'Euguélionne (2012 [1976]) by Louky Bersianik and The Handmaid's Tale (1985) by Margaret Atwood. Building on feminist scholarship, I find that the discursive apparatus of hegemonic masculinity in art worlds consists of a derogatory method of reading employed by critics in newspapers. This method of reading is founded on three discursive components: (i) a reductive reading of feminist politics; (ii) a man-centred assessment of feminism and (iii) a questioning of women's creative credibility which belittles the contribution of feminist authors. By translating the concept of boys' club (Delvaux, 2019) and identifying its derogatory method of reading, I propose a framework that illuminates how critical appraisal shapes discursive resources available for both professional and non-professional readers to draw upon for evaluation and classification of women's cultural productions and feminist engagements.

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BACKGROUND: A significant gap exists between the production of research evidence and its use in behavioral health policymaking. Organizations providing consulting and support activities for improving policy represent a promising source for strengthening the infrastructure to address this gap. Understanding the characteristics and activities of these evidence-to-policy intermediary (EPI) organizations can inform the development of capacity-building activities, leading to strengthened evidence-to-policy infrastructure and more widespread evidence-based policymaking. METHODS: Online surveys were sent to 51 organizations from English-speaking countries involved in evidence-to-policy activities in behavioral health. The survey was grounded in a rapid evidence review of the academic literature regarding strategies used to influence research use in policymaking. The review identified 17 strategies, which were classified into four activity categories. We administered the surveys via Qualtrics and calculated the descriptive statistics, scales, and internal consistency statistics using R. RESULTS: A total of 31 individuals completed the surveys from 27 organizations (53% response rate) in four English-speaking countries. EPIs were evenly split between university (49%) and non-university (51%) settings. Nearly all EPIs conducted direct program support (mean = 4.19/5 [sd = 1.25]) and knowledge-building (4.03 [1.17]) activities. However, engagement with traditionally marginalized and non-traditional partners (2.84 [1.39]) and development of evidence reviews using formal critical appraisal methods (2.81 [1.70]) were uncommon. EPIs tend to be specialized, focusing on a group of highly related strategies rather than incorporating multiple evidence-to-policy strategies in their portfolios. Inter-item consistency was moderate to high, with scale α's ranging from 0.67 to 0.85. Ratings of respondents' willingness to pay for training in one of three evidence dissemination strategies revealed high interest in program and policy design. CONCLUSIONS: Our results suggest that evidence-to-policy strategies are frequently used by existing EPIs; however, organizations tend to specialize rather than engage in a breadth of strategies. Furthermore, few organizations reported consistently engaging with non-traditional or community partners. Focusing on building capacity for a network of new and existing EPIs could be a promising strategy for growing the infrastructure needed for evidence-informed behavioral health policymaking.

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PURPOSE: Individuals with communication disabilities often face barriers when engaging with justice systems. Such barriers pose a material risk to the individual in relation to their right of equal access to justice. These barriers also pose a risk to the relevant State in potentially breaching Sustainable Development Goal 16 peace, justice and strong institutions (SDG 16). To mitigate these risks, many adversarial criminal justice systems have identified the need for accommodations to facilitate the participation of individuals with communication disabilities. RESULT: At the forefront of this movement has been the introduction of intermediaries. By facilitating effective communication between vulnerable persons and stakeholders within the legal system, intermediaries play a pivotal role in ensuring active participation in legal processes. They can also improve the forensic accuracy of the fact-finding inquiry. In this article, we outline case examples of intermediary schemes across three common law countries. As various terms are used to describe the intermediary role including communication assistants and registered intermediaries, the term intermediary will be used throughout. CONCLUSION: Although the scope of the role of intermediaries varies across settings in line with policy and legislative frameworks, we draw on shared learning across these countries to guide others in designing an intermediary scheme. We highlight the importance of knowledge sharing across contexts to realise equal access to justice for all (SDG 16).

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Diverse metabolic disorders can disrupt brain growth, and analyzing metabolism in animal models of microcephaly may reveal new mechanisms of pathogenesis. The metabolism of functioning cells in a living organism is constantly changing in response to a changing environment, circadian rhythms, consumed food, drugs, progressing sicknesses, aging, and many other factors. Metabolic profiling can give important insights into the working machinery of the cell. However, a frozen snapshot of the interconnected, complex network of reactions gives very limited information about this system. Flux analysis using stable isotope labels enables more robust metabolic studies that consider interrogate metabolite processing and changes in molecular concentrations over time.

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Background: Firms in the Marche Region, Italy, seem to struggle with understanding the importance of Industry 4.0 technologies, including blockchain technology, and delay the adoption of these innovative technologies. Methods: This paper is based on findings of three levels of qualitative analysis: the first one is a literature review; the second uses secondary sources about the diffusion of Industry 4.0 in the Marche Region and the local institutions and policies favouring it, retrieved from institutional websites and web searches; the third uses primary data which has been collected through an explorative survey conducted by sending a questionnaire to local innovative firms between 25th and the 27th of October 2022. Results: The literature review shows that collaboration between triple helix actors can foster innovation in firms. Secondary data about firms in the Marche Region describes an economy made prevalently of micro enterprises not capable of adopting Industry 4.0 technologies, and individuates some institutions located in the region having the role of innovation intermediaries that help firms innovate. Among the secondary sources, the new Smart Specialisation Strategy 2021-2027 of the Marche Region emphasises the role of Industry 4.0 for economic development which requires the involvement of the research and innovation actors present in the region. The survey conducted for this study shows that the firms that adopted Industry 4.0 technologies have strong ties and collaboration with triple helix institutions. Conclusions: Based on the findings, a triple helix model is proposed to foster the diffusion of Industry 4.0 technologies in the Marche Region, where innovation intermediaries are called to manage knowledge flows both among them and between academia, government, and industry, to activate a virtuous cycle of innovation adoption and valorisation.

Industry 4.0 (I4.0) technologies can help firms innovate their products and processes, but firms in the Marche Region, Italy, struggle adopting them. To understand what policy measures are necessary to help these firms innovate, an analysis of the Marche Region's context, key institutions, and policies is conducted and coupled with an explorative survey to firms in the Marche Region that already use I4.0 technologies. The results show that these firms collaborate with many public and private actors at the regional, national, and international levels. The paper suggests that innovation intermediaries, that are present in the region and already help firms innovate, could manage the knowledge flows among them and between government, academia, and industry so that firms can receive proper support in adopting I4.0.

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Background: Protein-protein interactions (PPIs) are essential to almost every process in a cell. Analysis of PPI networks gives insights into the functional relationships among proteins and may reveal important hub proteins and sub-networks corresponding to functional modules. Several good tools have been developed for PPI network analysis but they have certain limitations. Most tools are suited for studying PPI in only a small number of model species, and do not allow second-order networks to be built, or offer relevant functions for their analysis. To overcome these limitations, we have developed APPINetwork (Analysis of Protein-protein Interaction Networks). The aim was to produce a generic and user-friendly package for building and analyzing a PPI network involving proteins of interest from any species as long they are stored in a database. Methods: APPINetwork is an open-source R package. It can be downloaded and installed on the collaborative development platform GitLab (https://forgemia.inra.fr/GNet/appinetwork). A graphical user interface facilitates its use. Graphical windows, buttons, and scroll bars allow the user to select or enter an organism name, choose data files and network parameters or methods dedicated to network analysis. All functions are implemented in R, except for the script identifying all proteins involved in the same biological process (developed in C) and the scripts formatting the BioGRID data file and generating the IDs correspondence file (implemented in Python 3). PPI information comes from private resources or different public databases (such as IntAct, BioGRID, and iRefIndex). The package can be deployed on Linux and macOS operating systems (OS). Deployment on Windows is possible but it requires the prior installation of Rtools and Python 3. Results: APPINetwork allows the user to build a PPI network from selected public databases and add their own PPI data. In this network, the proteins have unique identifiers resulting from the standardization of the different identifiers specific to each database. In addition to the construction of the first-order network, APPINetwork offers the possibility of building a second-order network centered on the proteins of interest (proteins known for their role in the biological process studied or subunits of a complex protein) and provides the number and type of experiments that have highlighted each PPI, as well as references to articles containing experimental evidence. Conclusion: More than a tool for PPI network building, APPINetwork enables the analysis of the resultant network, by searching either for the community of proteins involved in the same biological process or for the assembly intermediates of a protein complex. Results of these analyses are provided in easily exportable files. Examples files and a user manual describing each step of the process come with the package.

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The incorporation of public organizations is meant to improve their efficiency and contribution to national and local economies. In Japan, incorporation has been implemented at the national and local levels since the late 1990s. This process alters the incentive system comprising intellectual property (IP) ownership, managerial freedom, and rent sharing, which promotes IP commercialization. This study assesses the economic consequences of the incentive system reform, taking the example of a public innovation intermediary, Kohsetsushi. Unlike the incorporation of national universities, the incorporation of Kohsetsushi is at the discretion of local governments. Therefore, there should be a comparative advantage for both incorporated and unincorporated Kohsetsushi. A dataset representative of both types of Kohsetsushi was established to estimate the average treatment effects on the treated (ATT), identify the type of selection into incorporation, and discuss the economic consequences of endogenous selection by local governments. The counterfactual analysis of licensing income revealed a negative ATT of incorporation and negative selection into not choosing incorporation. Incorporated Kohsetsushi would have had higher licensing income had they not been incorporated. The evidence does not support comparative advantage. The unintended consequence might have been caused by the lack of harmonization between the incentive and evaluation systems.

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How do performances contribute to meaning-making processes in cultural fields? This paper focuses on the spaces where performances happen and how music is framed and staged by intermediaries. I engage critically with cultural pragmatics from a Bourdieusian perspective to argue that performance contexts are central to the structure of music scenes, and that fusion may be understood as a moment when the "rules of the game" (Bourdieu 1993) of a cultural field are enacted, perpetuated, or contested. This article points to the role that cultural intermediaries play in shaping performances, interpreting systems of collective representation, and achieving fusion. I devise a framework to analyze how the Parisian music scene is organized and structured by a pure/impure binary linking specific music genres to performance contexts. I also examine how cultural intermediaries in Paris work within this frame, playing with performance "rules" to shape audiences' understandings and experiences of music in particular venues. Drawing on ethnographic observations conducted in two major venues, I show how bookers attempt to transform the "rules of the game" and position their venues as part of the avant-garde by mixing "pure" and "impure" elements of performance during the events.

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US-American philosopher Norman O. Brown (1913-2002) was one of the very few twentieth-century intellectuals to situate hermaphroditism at the core of their work. Although Brown's publications became cult books of the then emerging protest subcultures and were eventually regarded as milestones in the history of Freudian revisionism, the reception of his views on hermaphroditism has been insubstantial. The present contribution focuses at first on Brown's attempt to supersede binary sexuality and its same-sex/other-sex combinatories by positing an ambit of hermaphroditic reconciliation that emerges from the depths of the unconscious, but is effectual only as an eschatological ideal. Against this backdrop, Brown's consequential neglect of Charles Darwin's universalization of corporeal hermaphroditism and of Magnus Hirschfeld's conception of human sexual intermediariness are analyzed and assessed.

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Background: One pathway to addressing childhood obesity is through implementing evidence-based practices (EBPs) shown to promote nutrition and physical activity in K-12 school settings. Assess, Identify, Make it happen (AIM) is a strategic planning process to engage stakeholders in implementing EBPs in their K-12 schools. Local Public Health Agencies (LPHAs) are a potential partner to facilitate this process to a broader audience of rural school communities. Methods: A process and outcome evaluation design was applied in this study to examine the extent to which LPHAs effectively implemented AIM with rural/frontier schools in comparison to university staff. Data collection included post-meeting surveys completed by facilitators, a post-intervention interview with facilitators, a survey of school task force members at the end of the AIM process, and systematic documentation of the intervention. Results: Reach -Among the 26 eligible elementary schools, 18 (69%) agreed to participate. Effect -In total, schools facilitated by LPHAs fully implemented an average of 4.0 changes per school, while schools facilitated by the university staff fully implemented an average of 3.7 changes. Adoption -Among the five LPHAs in the target region, all five agreed to partner on the initiative, but some agencies were unable to identify sufficient personnel to facilitate all schools in their catchment area. Implementation -(1) In total, 89 of 94 (95%) meetings scheduled by LPHA facilitators occurred. 47 of 48 (98%) meetings scheduled by the university staff occurred. (2) The university staff self-reported 93% of agenda items in the AIM process as "completely" followed while LPHA facilitators reported 41% of agenda items as "completely" followed. (3) Task force satisfaction with the AIM process and facilitator showed limited variance across LPHAs and university-facilitated schools. Maintenance -Of the 16 school districts that agreed to participate in the school-based version of AIM, 9 (56%) also participated in a district-wide version of AIM 2 years later. Conclusion: AIM is an effective process for implementing EBPs in elementary schools when facilitated by LPHAs. Effective partnerships, a nuanced approach to fidelity, scalability considerations, and the role of technical assistance and training all contributed to the successful implementation of this LPHA-Elementary school partnership.