RESUMEN
HLA-C*05:286 differs from HLA-C*05:01:01:02 by one nucleotide substitution in codon 283 in exon 5.
Asunto(s)
Genes MHC Clase I , Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , Prueba de Histocompatibilidad , Codón , Análisis de Secuencia de ADNRESUMEN
Identification of the novel HLA-C*05:279 allele that differs from C*05:01:01:11 by two nucleotide substitutions.
Asunto(s)
Antígenos HLA-C , Trasplante de Riñón , Humanos , Antígenos HLA-C/genética , Alelos , Secuenciación de Nucleótidos de Alto Rendimiento , Exones/genéticaRESUMEN
HLA-C*05:282Q differs from HLA-C*05:01:01 by one nucleotide substitution in codon -24 in exon 1.
Asunto(s)
Antígenos HLA-C , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Antígenos HLA-C/genética , Alelos , Genes MHC Clase I , Exones/genéticaRESUMEN
HLA-C*05:01:01:81Q differs from HLA-C*05:01:01:02 by one nucleotide substitution in position 202 in intron 1 (c.74-2A>G, hg19).
Asunto(s)
Genes MHC Clase I , Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Exones/genética , Alelos , Prueba de Histocompatibilidad , Análisis de Secuencia de ADNRESUMEN
Full-length sequence of HLA-C*05:01:72 covers the 5'-untranslated region (UTR), all introns and exons and the 3' UTR.
Asunto(s)
Antígenos HLA-C , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Antígenos HLA-C/genética , Secuencia de Bases , Alelos , Exones/genética , Intrones , Análisis de Secuencia de ADNRESUMEN
The novel HLA-C*05:269 allele was characterized using next-generation sequencing technology.
Asunto(s)
Genes MHC Clase I , Antígenos HLA-C , Humanos , Alelos , Secuenciación de Nucleótidos de Alto Rendimiento , Prueba de HistocompatibilidadRESUMEN
HLA-C*05:255 differs from HLA-C*05:01:01:02 by one nucleotide substitution at position 2013 in exon 5.
Asunto(s)
Genes MHC Clase I , Antígenos HLA-C , Alelos , Exones/genética , Antígenos HLA-C/genética , Secuenciación de Nucleótidos de Alto Rendimiento , HumanosRESUMEN
The novel HLA-C*05:01:68 allele was characterized using two next generation sequencing technologies.
Asunto(s)
Antígenos HLA-C , Secuenciación de Nucleótidos de Alto Rendimiento , Alelos , Genes MHC Clase I , Antígenos HLA-C/genética , HumanosRESUMEN
HLA-C*05:01:58 differs from HLA-C*05:01:01:02 by a single nucleotide change in codon 112 in exon 3.
Asunto(s)
Genes MHC Clase I , Antígenos HLA-C , Alelos , Exones/genética , Antígenos HLA-C/genética , Prueba de Histocompatibilidad , Humanos , Análisis de Secuencia de ADNRESUMEN
HLA-C*05:156 allele differs from C*05:01:01:02 by a nucleotide change in exon 2 at codon 9.
Asunto(s)
Alelos , Antígenos HLA-C/genética , Análisis de Secuencia de ADN , Secuencia de Bases , Exones/genética , Hemicigoto , Prueba de Histocompatibilidad , HumanosRESUMEN
The sequencing of exons 2-7 of a likely new HLA-C*05 allele identified the second example of HLA-C*05:142, in a male UK European, within a few months of the first example being found in Germany. C*05:142 differs from C*05:01:01:01 by a single base (395G>C) in exon 3 resulting in an amino acid substitution of R108P. Comprehensive serological HLA-Cw5 typing, using 19 antisera, indicated that C*05:142 encodes a "normal" Cw5 specificity. Failure to identify the involvement of position 108 in published HLA-C epitopes supported this assertion. The likely HLA class I C*05:142-bearing haplotype is A*02:01~C*05:142~B*44:02. This new allele has a maximum frequency of 0.00001, in 34,743 sequenced-based typed subjects, contrasting with that of C*05:01 (allele frequency 0.10441), in our local, largely UK European, blood donors.
Asunto(s)
Alelos , Epítopos/genética , Exones , Frecuencia de los Genes , Antígenos HLA-C/genética , Mutación Missense , Sustitución de Aminoácidos , Humanos , Reino UnidoRESUMEN
HLA-C*05:99N results from a single nucleotide loss compared with its closest allele HLA-C*05:01:01:01.