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1.
Int J Clin Oncol ; 29(8): 1122-1132, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38696052

RESUMEN

BACKGROUND: The Union for International Cancer Control and American Joint Committee on Cancer tumor staging system is used globally for treatment planning. As it may be insufficient for tumor staging of lower gingival carcinomas, we proposed the mandibular canal tumor staging system. In this study, we aimed to compare the two systems for such tumor staging and to identify prognostic markers. METHODS: This multicenter, retrospective study included patients with lower gingival squamous cell carcinoma who underwent radical surgery during 2001-2018. We compared survival rates (Kaplan-Meier estimator) and patient stratification according to the two systems. RESULTS: The proposed system yielded more balanced patient stratification than the existing system. Progression in the tumor grade according to the proposed system was associated with a poorer prognosis. The 5-year overall and disease-specific survival rates for the entire cohort were 74.9% and 81.8%, respectively. Independent factors affecting overall survival were tumor stage according to the proposed system, excision margins, and number of positive nodes, whereas those affecting disease-specific survival were excision margins and number of positive nodes. CONCLUSIONS: Subsite-specific tumor classification should be used for patients with oral cancer, and our results suggest that mandibular canal tumor classification may be effective for patients with lower gingival carcinoma.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias Gingivales , Estadificación de Neoplasias , Humanos , Masculino , Estudios Retrospectivos , Femenino , Persona de Mediana Edad , Neoplasias Gingivales/patología , Neoplasias Gingivales/cirugía , Neoplasias Gingivales/mortalidad , Anciano , Pronóstico , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/cirugía , Carcinoma de Células Escamosas/mortalidad , Adulto , Tasa de Supervivencia , Anciano de 80 o más Años , Mandíbula/patología , Mandíbula/cirugía
2.
SciELO Preprints; dez. 2023.
Preprint en Español | SciELO Preprints | ID: pps-7582

RESUMEN

Odontogenic oral lesions in pediatric patients It is essential to understand the pathogenesis of odontogenic tumors. The clinical presentation, microscopic features, and prognosis are addressed for odontogenic lesions in the newborn, but familiarity with these entities is essential due to the different therapeutic implications of these diagnoses. The case we present is a five-day-old newborn in the Neonatology service of the Dos de Mayo National Hospital, Peru, the reason for consultation was "he was born with a lump in his mouth." On clinical inspection, a palatine lobe was found. The palatine lobe was presented for inspection. Conventional outpatient surgery is performed to remove the foreign body, completely removing the tumor. The surgical specimen was sent to pathology, which confirmed the definitive diagnosis: congenital epulis of the newborn.


Lesiones orales odontogénicos en pacientes pediátricos es esencial comprender la patogénesis de los tumores odontogénicos. La presentación clínica, las características microscópicas y el pronóstico se abordan para las lesiones odontogénicos en el recién nacido, pero la familiaridad con estas entidades es esencial debido a las diferentes implicaciones terapéuticas de estos diagnósticos. El caso que presentamos es un recién nacido de cinco días en el servicio de Neonatología del Hospital Nacional Dos de Mayo, Perú, el motivo de consulta "nació con un bulto en la boca". En la inspección clínica se encontró un lóbulo palatino. Presentaba a la inspección el lóbulo palatino. Se realiza una cirugía convencional ambulatoria para retirar el cuerpo extraño, extirpando de manera total la tumoración. Se envió la pieza quirúrgica a patología, en los resultando confirmaron como diagnóstico definitivo: épulis congénito del recién nacido.


Lesões orais odontogênicas em pacientes pediátricos É essencial compreender a patogênese dos tumores odontogênicos. A apresentação clínica, as características microscópicas e o prognóstico são abordados nas lesões odontogênicas do recém-nascido, mas a familiaridade com essas entidades é essencial devido às diferentes implicações terapêuticas desses diagnósticos. O caso que apresentamos é um recém-nascido de cinco dias atendido no serviço de Neonatologia do Hospital Nacional Dos de Mayo, Peru, o motivo da consulta foi "ele nasceu com um caroço na boca". Na inspeção clínica, foi encontrado um lobo palatino. O lobo palatino foi apresentado para inspeção. A cirurgia ambulatorial convencional é realizada para retirada do corpo estranho, retirando completamente o tumor. A peça cirúrgica foi encaminhada ao serviço de patologia, que confirmou o diagnóstico definitivo: epúlide congênita do recém-nascido.

3.
Indian J Surg Oncol ; 14(3): 733-741, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37900650

RESUMEN

In India, oral cancers are the major cause of cancer-related death. Tongue and buccal mucosa being the major subsites in oral cancer have varying clinicopathological presentations. This study is intended to know the difference in clinicopathological behavior of these two subsites. This retrospective study included 474 patients of which 232 patients had tongue cancer and 242 patients had buccal alveolar complex (BAC) cancer. Comparison between the pathological characters including pattern of nodal involvement was analyzed. Disease-free survival (DFS) and factors influencing the DFS were analyzed and compared using Cox regression analysis. Mean age of the study population was 52.7 years. Tongue oral squamous cell carcinoma (OSCC) differed significantly from BAC OSCC in terms of age of presentation, tumor staging, and perineural invasion. Among neck nodal involvement, tongue OSCC commonly involved level IIa (p < 0.001) whereas BAC involved level Ib (p < 0.001). At a median follow-up of 27 months, 141 patients had disease recurrence, tongue OSCC commonly recurred in neck (p = 0.008), and BAC OSCC relapsed at primary site (p = 0.001). Patients older than 45 years with BAC cancer had lesser risk of recurrence (HR, 0.30; 95% CI, 0.2-0.5; p < 0.0001). Pathological tumor stage in tongue cancer (HR, 14.9; 95% CI, 2.6-84.8; p = 0.002) and grade of tumor differentiation in BAC OSCC (HR, 9.2; 95% CI, 1.9-43.3; p < 0.005) were the most significant factors that influenced tumor recurrence. There was a significant difference in factors influencing disease recurrence among tongue and BAC OSCC. Also, pattern of nodal metastasis and pattern of recurrence were different. Hence, further research on OSCC may be done site specific. Supplementary Information: The online version contains supplementary material available at 10.1007/s13193-023-01750-8.

4.
Beijing Da Xue Xue Bao Yi Xue Ban ; 55(4): 702-707, 2023 Aug 18.
Artículo en Chino | MEDLINE | ID: mdl-37534655

RESUMEN

OBJECTIVE: To define the clinical factors that influence local recurrence and survival in patients with lower gingival squamous cell carcinoma (LGSCC) and determine whether bone invasion is an independent prognostic factor for them. METHODS: A total of 104 patients with LGSCC hospitalized in Peking University Stomatology Hospital from June 2013 to December 2015 were enrolled in this retrospective study.All the patients were followed-up for more than 3 years.The degree of bone invasion was assessed using preoperative imaging data (CT and panoramic radiograph).The degree of bone invasion was divi-ded into four categories: no bone invasion, invasion of cortical bone, invasion of bone marrow cavity, and invasion of the mandibular canal.According to the central position of tumor, it was divided into two types: anterior mandibular invasion (anterior region of the mental foramen) and posterior mandibular invasion (posterior region of the mental foramen). RESULTS: of different invasion depth groups were compared using Mann-Whitney U test.P value < 0.05 was considered to be statistically significant.Kaplan-Meier survival analysis method was used to draw survival curve, and COX regression was used to explore the risk ratio (HR) and 95% confidence interval (CI) of prognostic factors of LGSCC. RESULTS: The follow-up results showed that the 1-, 3-, and 5-year survival rates of LGSCC in this group were 91%, 84%, 82%, respectively.32.7%(34/104) of patients had cervical lymph node metastasis.The cervical lymph node metastasis rate of the anterior segment of the mandible was 12.5%(2/16), and 36.4%(32/88) for the posterior segment of the mandible (P < 0.05).Univariate and multivariate COX analysis showed that the N stage and local recurrence were the prognostic factors of LGSCC patients (P < 0.05). CONCLUSION: As the degree of mandibular invasion increases, the prognosis of patients with mandibular gum cancer becomes worse.N stage and local recurrence are prognostic risk factors for LGSCC.The incidence of cervical lymph node metastasis for LGSCC is related to the primary tumor location.It is concluded that tumors located at the posterior of the mandible might be more prone to cervical lymph node metastasis than the anterior of the mandible.Thus various levels of cervical lymph node dissection strategies should be adopted for different sites of LGSCC.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias Gingivales , Humanos , Masculino , Femenino , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Neoplasias Gingivales/patología , Estudios Retrospectivos , Pronóstico , Metástasis Linfática
5.
Artículo en Español | IBECS | ID: ibc-222283

RESUMEN

Background: To evaluate the prevalence and clinicopathological features of a large series of gingival neoplasms in Brazil. Material and methods: All gingival benign and malignant neoplasms were retrieved from the records of six Oral Pathology Services in Brazil, during a 41-year period. Clinical and demographic data, clinical diagnosis, and histopathological data were collected from the patients' clinical charts. For statistical analysis, the chi-square, median test of independent samples and the U Mann-Whitney tests were used, considering a significance of 5%. Results: From 100,026 oral lesions, 888 (0.9%) were gingival neoplasms. There were 496 (55.9%) males, with a mean age of 54.2 years. Most cases (70.3%) were malignant neoplasms. Nodules (46.2%) and ulcers (38.9%) were the most common clinical appearance for benign and malignant neoplasms, respectively. Squamous cell carcinoma (55.6%) was the most common gingival neoplasm, followed by squamous cell papilloma (19.6%). In 69 (11.1%) malignant neoplasms, the lesions were clinically considered to be inflammatory or of infectious origin. Malignant neoplasms were more common in older men, appeared with larger size, and with a time of complaint shorter than benign neoplasms (p<0.001). Conclusions: Benign and malignant tumors may appear as nodules in gingival tissue. In addition, malignant neoplasms, especially squamous cell carcinoma, should be considered in the differential diagnosis of persistent single gingival ulcers. (AU)


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Neoplasias Gingivales/epidemiología , Neoplasias Gingivales/patología , Neoplasias de la Boca , Brasil/epidemiología , Patología Bucal , Distribución de Chi-Cuadrado , Estadísticas no Paramétricas , Prevalencia
6.
Arch. pediatr. Urug ; 93(1): e305, jun. 2022. ilus
Artículo en Español | LILACS, UY-BNMED, BNUY | ID: biblio-1383646

RESUMEN

El épulis congénito es una patología neonatal muy rara. Se trata de un tumor benigno pediculado de la mucosa de los maxilares, más frecuentemente localizado en maxilar superior en relación 2-3/1. Se describe el caso de un recién nacido de sexo femenino, de término, adecuado, vigoroso. Se constata al nacimiento la presencia de un épulis congénito que causa alteraciones de la succión. Se realiza intervención quirúrgica temprana, con resolución de la patología sin complicaciones.


Congenital epulis is a very rare neonatal pathology. It is a benign pedunculated tumor of the jaw mucosa, most frequently located in the upper jaw in a 2-3 / 1 ratio. The case of a newborn, female, term, adequate, vigorous is described. Noting at birth a congenital Epulis that causes suction alterations. Early surgical intervention is perfomed with resolution of the pathology without complications.


A epúlide congênita é uma patologia neonatal muito rara. É um tumor pedunculado benigno da mucosa dos maxilares, mais frequentemente localizado no maxilar superior na proporção de 2-3/1. Descreve-se o caso de um recém-nascido, do sexo feminino, a termo, adequado, vigoroso. Verificando ao nascimento uma Epúlide congênita que causa alterações na sucção. A intervenção cirúrgica precoce é realizada com resolução da patologia sem complicações.


Asunto(s)
Humanos , Masculino , Recién Nacido , Neoplasias Gingivales/cirugía , Neoplasias Gingivales/diagnóstico , Neoplasias Gingivales/patología
7.
Cureus ; 14(4): e23897, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35530856

RESUMEN

Plasma cell granuloma (PCG), also known as inflammatory pseudotumor, is of unknown etiopathogenesis. It commonly presents in the lungs and can also occur in the liver, kidney, brain, and heart. PCG is rare in the oral cavity and even rarer in the gingiva. The clinical and radiological presentation of this disease in the oral cavity appears to be aggressive in nature and is often misdiagnosed as a malignant lesion. Histopathology helps in distinguishing PCG of gingiva from other benign and malignant lesions of the gingiva. Amlodipine and cyclosporine-induced PCG of gingiva have been reported in the literature. This report presents a rare case of generalized plasma cell granuloma of the gingiva in an adult female patient who was on hormonal therapy for infertility. Treatment consisted of complete surgical excision of the lesion and extraction of teeth with a poor prognosis. Wound healing was uneventful during the one-year follow-up period with no signs of recurrence.

8.
Cureus ; 14(1): e20904, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35145808

RESUMEN

The aim of the present article is to present the clinical case of a large peripheral ossifying fibroma that evolved from a previously diagnosed pyogenic granuloma in a 50-year-old woman. The patient was referred for treatment of a lesion over the buccal and palatal gingiva close to the left upper first molar. It was purplish-red in color, approximately 3 cm in diameter, having a smooth surface, a pedicled and bleeding base, with seven years of evolution, and diagnosed as pyogenic granuloma. After three years of evasion, the patient returned reporting an increase in the lesion and difficulty in eating. Clinically the nodule was lobular in appearance, pink in color and smooth, pediculated, firm in consistency, non-bleeding, about 5 cm in its greatest extension, extending to the maxillary tuberosity. The lesion was excised and referred for histopathological examination, which led to the diagnosis of peripheral ossifying fibroma. The patient was followed for approximately 18 months, prosthetically rehabilitated, with satisfactory healing and no clinical signs of recurrence. The possible evolution of a pyogenic granuloma to a peripheral ossifying fibroma was observed in this case, based on the histopathological changes that occurred, with the development of calcified material, fibrous maturation, and decreased vascular content of the initial lesion after three years.

9.
Indian J Cancer ; 59(4): 565-570, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36861524

RESUMEN

Background: Reconstruction of anterior segmental mandibulectomy still remains a challenge. Osteocutaneous free flap remains the ideal choice of reconstruction because it restores cosmesis and function. The use of other locoregional flaps compromises cosmesis and function. Here, we have introduced a unique technique of reconstruction with lingual cortex mandibular plate as an alternate choice for free flap. Method: Six patients aged 12-62 years underwent oncological resection for oral cancer which involved the anterior segment of the mandible. Following resection, they underwent lingual cortex mandibular plating with pectoralis major myocutaneous flap reconstruction. Adjuvant radiotherapy was delivered to all patients. Results: The mean bony defect was 9.2 cm. There were no significant perioperative events related to the surgery. None required tracheostomy and all were safely extubated with no post-surgical complications. The cosmetic and functional outcomes were acceptable. Following the completion of radiotherapy with a median follow-up of 11 months, Plate exposure occurred in one patient. Conclusion: The technique is cheap, quick and simple, and can be effectively applied in resource-constrained and demanding situations. It is possible to consider this as an alternative treatment strategy for osteocutaneous free flap in anterior segmental defects.


Asunto(s)
Osteotomía Mandibular , Músculos Pectorales , Humanos , Músculos Pectorales/cirugía , Colgajos Quirúrgicos , Extubación Traqueal , Oncología Médica
10.
Head Neck Pathol ; 16(2): 339-343, 2022 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34224081

RESUMEN

Peripheral ossifying fibromas (POFs) and peripheral odontogenic fibromas (POdFs) appear clinically similar but of different histogenesis. The novel marker SATB2 is involved in regulation of osteoblastic differentiation and phenotype. However, SATB2 expression has not been previously explored in POFs and POdFs. Given the potential for mineralized tissue formation in POFs and POdFs, and to more clarify the phenotype of the lesional cells, this study was aimed to immunohistochemically investigate SATB2 expression in POFs and POdFs. Fourteen cases of POF and POdF (7 cases each) were selected, stained for SATB2 immunohistochemically, and scored according to the percentage of positive lesional cells (0, no staining; 1 +, < 5%; 2 +, 5-25%; 3 +, 26-50%; 4 +, 51-75%; and 5 +, 76-100%), and the intensity of staining was graded as weak, moderate, or strong. The control group included the inflammatory fibrous hyperplasia-like area present in two cases, 1 case fibroma, and 1 case giant cell fibroma. Moderate to strong, and diffuse SATB2 nuclear immunoreactivity was detected in the lesional cells of all cases of POFs and POdFs with variable scores; 3-5 + for the POFs and 3-4 + for the POdFs (P = 0.101). The distribution of staining was more prominent in those lesional cells associated with the osteoid/calcification in the cases of POFs. No staining was noted in the control group. The lesional cells in both POFs and POdFs express SATB2 and may exhibit the osteoblastic-like phenotype. SATB2 staining may be useful for diagnosis of subsets of POFs with minimal or absent calcification and some POdFs with unidentifiable odontogenic epithelium.


Asunto(s)
Calcinosis , Fibroma Osificante , Neoplasias Gingivales , Proteínas de Unión a la Región de Fijación a la Matriz , Tumores Odontogénicos , Factores de Transcripción , Fibroma Osificante/diagnóstico , Neoplasias Gingivales/diagnóstico , Humanos , Hiperplasia , Proteínas de Unión a la Región de Fijación a la Matriz/genética , Tumores Odontogénicos/diagnóstico , Factores de Transcripción/genética
11.
J Stomatol Oral Maxillofac Surg ; 123(5): e474-e483, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-34933137

RESUMEN

OBJECTIVE: Metastasis to oral and maxillofacial region (MOMFR) is an unusual finding; representing between 1 and 1.5% of all malignancies in the maxillofacial region. A systematic review is presented to determine trends in presentation, diagnostic features, and patient outcome. METHODS: Searches of databases were carried out for papers reporting MOMFR. The variables were demographics, patient symptoms, tumor location, tumor size, histopathology, origin of the tumor, immunohistochemical studies, follow-up and survival. RESULTS: 696 cases were identified; 391 males, and 305 females. The most common race was white. The most common primary tumor for females was from breast 31.1% (n = 95), for males from lung 20.5% (n = 143). The most common location was the mandible 44.9% (n = 313), followed by gingival soft tissue 16.8% (n = 117). A frequent clinical symptom was pain with 17.5% (n = 122). The most common clinical presentation was a mass or tumor 37.4% (n = 260). The mean age was 58.8 years. The average time before diagnosis was 10.3 months, the mean follow-up after diagnosis was 13.1 months, and the average survival was 9.8 months. CONCLUSION: MOMFR shows a strong predilection for the posterior mandible, with a mass or tumor being the most common clinical presentation. They are frequently painful, and demonstrate a poor prognosis.


Asunto(s)
Neoplasias de la Boca , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/epidemiología , Neoplasias de la Boca/secundario
12.
Gen Dent ; 69(6): 54-57, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34678744

RESUMEN

The objective of this case report is to describe a congenital epulis of the newborn. A 10-day-old female neonate was brought to a dental clinic for examination of an intraoral lesion that was present at birth. No systemic changes were noted during the extraoral examination. During the intraoral examination, a nodular exophytic lesion was found in the maxillary left alveolar ridge. The appearance suggested a congenital epulis. The nodular, pedunculated lesion had a diameter of 13 mm, firm consistency, smooth surface, and color varying from pink to red. Newborns with such lesions usually have difficulty breastfeeding and may experience respiratory difficulties. The patient underwent an excisional biopsy under local infiltrative anesthesia with 2% lidocaine. Histopathologic examination of the lesion confirmed the diagnosis of congenital epulis. There were no postoperative complications. At the follow-up examination 8 days after the biopsy, her weight and length had already increased, and the oral mucosa had a normal appearance. At 8 months of age, she demonstrated continued gains in weight and length. Dentists must familiarize themselves with abnormalities that may affect the oral cavity of neonates as well as the differential diagnoses and treatment options.


Asunto(s)
Neoplasias Gingivales , Tumor de Células Granulares , Proceso Alveolar , Femenino , Neoplasias Gingivales/diagnóstico , Neoplasias Gingivales/cirugía , Humanos , Recién Nacido , Maxilar
13.
Rev Med Inst Mex Seguro Soc ; 58(2): 212-215, 2020 04 13.
Artículo en Español | MEDLINE | ID: mdl-34101567

RESUMEN

BACKGROUND: The newborn congenital epulis or granular cell tumor is a benign tumor that appears in the oral cavity of newborns with more frequency in the gingiva of the alveolar crest of the maxilla at the level of the incisive and canine area, predominantly in the female sex. It is of diagnostic importance since it can interfere with feeding, swallowing and via area, putting the health of the newborn at risk. It usually involutes spontaneously and in case of surgical treatment there are no reports of recurrence. The aim of this work was to describe the evolution according to the approach of this patient with congenital newborn epulis. CASE REPORT: The case of a patient of the newborn congenital epulis and its follow-up for 6 years is reviewed. CONCLUSIONS: The surgical treatment of the newborn congenital epulis seems to be a good option of approach without the difficulties in the feeding, suction and breathing of the newborn.


INTRODUCCIÓN: El épulis congénito del recién nacido, o tumor de células granulares, es un tumor benigno que aparece en cavidad oral de los recién nacidos, con mayor frecuencia en la encía de la cresta alveolar del maxilar a nivel del área incisiva y canina, predominando en el sexo femenino. Es de importancia diagnóstica, ya que puede interferir con la alimentación, la deglución y la vía área, poniendo en riesgo la salud del recién nacido. Generalmente involuciona de manera espontánea y, en caso de tratamiento quirúrgico, no hay informes de recurrencia. Decidir la forma de abordaje en un recién nacido, por la complejidad y la inmadurez del organismo, implica un gran reto para los neonatólogos, los cirujanos pediatras y los especialistas del área bucal, como son los odontopediatras y los cirujanos maxilofaciales. El objetivo de este trabajo fue describir la evolución según el abordaje de esta paciente con épulis congénito del recién nacido. CASO CLÍNICO: Se revisa el caso de una paciente con épulis congénito del recién nacido tratada quirúrgicamente y su seguimiento durante 6 años. CONCLUSIONES: De acuerdo con la evolución de este caso se puede concluir que el tratamiento quirúrgico puede ser una buena opción de abordaje sin que se presenten dificultades en la alimentación, la succión ni la respiración.


Asunto(s)
Neoplasias Gingivales , Tumor de Células Granulares , Animales , Deglución , Perros , Femenino , Neoplasias Gingivales/diagnóstico , Neoplasias Gingivales/cirugía , Humanos , Recién Nacido , Recurrencia Local de Neoplasia , Succión
14.
Rev. Hosp. Ital. B. Aires (2004) ; 37(4): 146-148, dic. 2017. ilus
Artículo en Español | LILACS | ID: biblio-1095758

RESUMEN

El linfoma difuso de células B grandes (LDCBG) es el linfoma más frecuente. La presentación clínica puede ser nodal o extranodal y sus síntomas dependen de la localización tumoral; en la mayoría de los casos están asociados a algún tipo de inmunodeficiencia. Referiremos un caso de LDCBG de presentación atípica en una localización muy infrecuente. Es importante tener en cuenta estas situaciones, ya que pueden simular otros procesos patológicos, retrasando así su correcto diagnóstico y por lo tanto un adecuado tratamiento. (AU)


Diffuse large cell lymphoma B (LDCBG) is the most common type of lymphoma. It´s clinical presentation can be nodal or extranodal and it's symptoms depend where the tumor is located and whether is associated or not with an immunodeficiency disease. We present an atypical presentation of a LDCBG in a very unusual location. It´s important to consider these kind of appearance, as they can mimic other oral pathological processes, delaying their correct diagnosis and therefore an appropriate treatment. (AU)


Asunto(s)
Humanos , Masculino , Anciano , Linfoma no Hodgkin/diagnóstico , Neoplasias Gingivales/diagnóstico por imagen , Linfoma de Células B Grandes Difuso/diagnóstico , Linfoma no Hodgkin/clasificación , Linfoma no Hodgkin/etiología , Neoplasias de la Boca/diagnóstico , Linfoma de Células B Grandes Difuso/terapia , Linfoma de Células B Grandes Difuso/diagnóstico por imagen , Seronegatividad para VIH/inmunología , Herpesvirus Humano 4/inmunología , Úlceras Bucales/patología , Mucosa Bucal/patología
15.
Int. j. odontostomatol. (Print) ; 11(2): 178-181, June 2017. ilus
Artículo en Español | LILACS | ID: biblio-893248

RESUMEN

El Fibroma Odontogénico Periférico fue definido por la OMS en el año 2005 como una neoplasia benigna rara constituida por tejido fibroso maduro y una cantidad variable de epitelio odontogénico inactivo. Dada su presentación clínica, localización y baja prevalencia suele ser mal diagnosticado como una lesión reaccional. Se presenta un caso clínico de fibroma odontogénico periférico tratado mediante remoción quirúrgica y se realiza una revisión de la bibliografía respecto a la patología con el propósito de esclarecer algunos aspectos de esta lesión, además de incluirla dentro de los posibles diagnósticos diferenciales de lesiones reaccionales gingivales. El objetivo del siguiente artículo es presentar un caso clínico de FOP tratado mediante remoción quirúrgica y aportar en el diagnóstico diferencial de las lesiones reaccionales gingivales.


Peripheral odontogenic fibroma was described by the World Health Organization (WHO) in 2005, as a rare benign tumor containing mature fibrous connective tissue with a varying amount of inactive odontogenic epithelium. Though its clinical presentation, localization and low prevalence, it tends to be misdiagnosed as a reactive lesion. We present a case report of a Peripheral Odontogenic Fibroma treated by surgical resection and a narrative review of the literature with the purpose of clarifying different aspects of this lesion besides considering it as a possible differential diagnosis of reactive gingival lesions. The purpose of this article is to present a case report of peripheral odontogenic fibroma treated by surgical resection. Also to contribute to the differential diagnosis of gingival reactive lesions.


Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Neoplasias Gingivales/cirugía , Neoplasias Gingivales/diagnóstico , Tumores Odontogénicos/cirugía , Tumores Odontogénicos/diagnóstico , Resorción Dentaria/etiología , Neoplasias Gingivales/patología , Tumores Odontogénicos/patología , Diagnóstico Diferencial , Fibroma
16.
Sultan Qaboos Univ Med J ; 17(4): e472-e476, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29372093

RESUMEN

Leiomyosarcoma (LMS) is a rare mesenchymal malignancy, of which 3-10% of cases occur in the head and neck region. We report a 22-year-old woman who was referred to the University Hospital of Siena, Italy, in 2016 with an ostensibly benign asymptomatic lump on the mandibular gingiva. The lesion grew rapidly, causing otalgia in the right ear. An excisional biopsy was performed and primary LMS was diagnosed histologically. Subsequently, the patient underwent radical re-excision of the perilesional mucosa, a partial bone resection and the extraction of four teeth. No recurrences or metastases were detectable at a 20-month follow-up. This report discusses the differential diagnosis of LMS with regards to other benign and malignant lesions and reviews the recent literature on primary and secondary oral LMS. Due to its innocuous clinical features-including its asymptomatic nature and presentation at a young age-this aggressive malignancy can go undetected; therefore, an early histopathological diagnosis is crucial.


Asunto(s)
Neoplasias Gingivales/cirugía , Leiomiosarcoma/cirugía , Femenino , Encía/anomalías , Encía/cirugía , Neoplasias Gingivales/diagnóstico , Humanos , Italia , Leiomiosarcoma/diagnóstico , Tomografía Computarizada por Rayos X/métodos , Adulto Joven
17.
Iran J Pathol ; 12(4): 397-401, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-29563937

RESUMEN

Large, atypical peripheral ossifying fibromas are known as giant peripheral ossifying fibromas. These lesions have often been associated with heterogeneous clinical and radiographic characteristics subsequently leading to their misdiagnosis. Biopsies have been the gold standard for the diagnosis of such lesions. This study reports on an acute presentation of giant peripheral ossifying fibroma, clinically mimicking a malignant lesion due to its atypical presentation along with its characteristic histological features, which led to the establishment of the diagnosis.

18.
Pol J Radiol ; 80: 395-7, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26379808

RESUMEN

BACKGROUND: Congenital epulis is a rare benign jaw tumor. It is a reactive or degenerative lesion having a mesenchymal origin; presenting as an obvious mass arising from the gingival mucosa of the maxilla or mandible, presenting in neonates. Its etiology, histopathogenesis and natural history are still not well established. It is seen usually in the female gender and mostly involves the maxillary alveolar ridge. MATERIAL/MEHODS: We report a case of a 2.7 kg male baby born with growth on his mandibular ridge which was excised and was proved to be epulis on histopathology. RESULTS: Congenital epulis is often misdiagnosed before surgery because of its rarity and a lack of awareness of the condition by clinicians. It is important for the attending pediatricians, pediatric surgeon to be aware of this rare but benign congenital tumor. CONCLUSIONS: Congenital epulis is often misdiagnosed before surgery because of its rarity and a lack of awareness of the condition by clinicians. As the clinical presentation of this congenital tumor can be distressing due to its size and aggressive appearance, it is important for the attending pediatricians, pediatric surgeon to be aware of this rare but benign congenital tumor.

19.
RGO (Porto Alegre) ; 62(3): 315-318, Jul-Sep/2014. graf
Artículo en Inglés | LILACS | ID: lil-732727

RESUMEN

Congenital epulis is an uncommon benign lesion that affects the oral cavity of newborns, and presents histological features which are similar to those of granular cell tumor. The origin of this lesion has not been fully elucidated, and many hypotheses are considered due to the large variety of cell types observed in histological sections. Epulis development occurs further in the prenatal period, and is more common in newborn females, frequently in the maxilla. This lesion usually is presentend as a nodule covered by normal oral mucosa, which in some cases, interferes with baby's breathing and feeding. This report describes the case of a two-month-old male baby who presented a pedunculated intraoral lesion in the mandibular alveolar ridge. Histological sections revealed presence of mucosal fragments with atrophic squamous stratified epithelium, and fibrous connective tissue composed of cells with granular and eosinophilic cytoplasm. A few days after initial exam, the lesion detached from alveolar ridge, and healed spontaneously.


A epúlide congênita é uma lesão benigna rara que acomete a cavidade oral de recém-nascidos e apresenta características histológicas semelhantes às do tumor de células granulares. A origem da lesão ainda não foi completamente elucidada, e as muitas hipóteses a respeito de sua histogênese baseiam-se na grande variedade de tipos celulares observados nos cortes histológicos. A epúlide desenvolve-se ainda no período pré-natal, e é mais comum em recém-nascidos do sexo feminino, ocorrendo com mais freqüência na maxila. Esta lesão costuma apresentar-se como um nódulo coberto por mucosa oral normal que, em alguns casos, interfere na respiração e na alimentação do bebê. Esse artigo descreve o caso de um bebê do gênero masculino, leucoderma, de dois meses de idade, que apresentava lesão intra-oral pediculada com implantação débil na região alveolar da mandíbula. Cortes histológicos revelaram a presença de fragmento de mucosa revestido por epitélio pavimentoso estratificado atrófico, e de tecido conjuntivo fibroso composto de células com citoplasma granular e eosinofílico abundante. Alguns dias após o exame inicial, a lesão desprendeu-se do rebordo alveolar, sofrendo resolução espontânea.

20.
Rev. colomb. anestesiol ; 39(3): 405-408, ago.-oct. 2011. ilus
Artículo en Inglés, Español | LILACS | ID: lil-594633

RESUMEN

Introducción. El épulis del recién nacido es un tumor de células granulares originado en la mucosa de la cresta alveolar dental. Se presenta como una masa de tejido blando pedunculado, que puede ser lobular o multinodular. Es más habitual en mujeres que en hombres (8:1), debido, quizás, a factores hormonales en su génesis. Puede acompañarse de otras malformaciones congénitas. El manejo anestésico se basa en su potencial dificultad para la intubación y el riesgo de sangrado. Objetivos. Presentar el caso de un recién nacido con épulis congénito y hacer revisión de esta entidad y de su manejo anestésico. Métodos y resultados. Presentación de este caso clínico. Conclusiones. Hay descritos varios tipos de anestesia, dependiendo, entre otros factores, del tamaño del tumor y de los profesionales que intervienen en su exéresis. En nuestro caso, y dadas las características del tumor, optamos por una sedación inhalatoria con O2 /aire / sevofluorane, posición en decúbito lateral e infiltración local en la base del implantación. El éxito de la intervención debe basarse en una buena colaboración quirúrgico-anestésica.


Introduction. epulis of the newborn is agranular cell tumor arising in the mucosa of the dental ridge. It presents as a pedunculated soft tissue mass that can be lobular or multinodular.It is more common in females than inmales (8:1) perhaps due to hormonal factors. It may be accompanied by other congenital malformations. Anesthetic management is based on a potentially difficult intubation and the risk of bleeding. Objectives. To present the case of a newborn with congenital epulis and to review this pathologyand its anesthetic management.Methods and Results Clinical case presentation. Conclusions. Several types of anesthesia havebeen described depending, among other factors, on tumor size and on the professionals involved in excising the lesion. In our case, and given the characteristics of the tumor, we chose inhalation sedation with O2 / air / sevoflurane, lateral decubitus position and local infiltration at the base of implantation. Good collaboration between the surgeon and the anesthetist is critical for success.


Asunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Lactante , Anestesia , Anomalías Congénitas , Neoplasias Gingivales , Tumor de Células Granulares , Laringoscopía , Anestesia , Laringoscopía
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