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1.
Sensors (Basel) ; 24(17)2024 Aug 24.
Artículo en Inglés | MEDLINE | ID: mdl-39275410

RESUMEN

In this article, the authors present the design of a compact multiband monopole antenna measuring 30 × 10 × 1.6 mm3, which is aimed at optimizing performance across various communication bands, with a particular focus on Wi-Fi and sub-6G bands. These bands include the 2.4 GHz band, the 3.5 GHz band, and the 5-6 GHz band, ensuring versatility in practical applications. Another important point is that this paper demonstrates effective methods for reducing mutual coupling through two meander slits on the common ground, resembling a defected ground structure (DGS) between two antenna elements. This approach achieves mutual coupling suppression from -6.5 dB and -9 dB to -26 dB and -13 dB at 2.46 GHz and 3.47 GHz, respectively. Simulated and measured results are in good agreement, demonstrating significant improvements in isolation and overall multiple-input multiple-output (MIMO) antenna system performance. This research proposes a compact multiband monopole antenna and demonstrates a method to suppress coupling in multiband antennas, making them suitable for internet of things (IoT) sensor devices and Wi-Fi infrastructure systems.

2.
Sensors (Basel) ; 24(17)2024 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-39275576

RESUMEN

Wi-Fi fingerprint-based indoor localization methods are effective in static environments but encounter challenges in dynamic, real-world scenarios due to evolving fingerprint patterns and feature spaces. This study investigates the temporal variations in signal strength over a 25-month period to enhance adaptive long-term Wi-Fi localization. Key aspects explored include the significance of signal features, the effects of sampling fluctuations, and overall accuracy measured by mean absolute error. Techniques such as mean-based feature selection, principal component analysis (PCA), and functional discriminant analysis (FDA) were employed to analyze signal features. The proposed algorithm, Ada-LT IP, which incorporates data reduction and transfer learning, shows improved accuracy compared to state-of-the-art methods evaluated in the study. Additionally, the study addresses multicollinearity through PCA and covariance analysis, revealing a reduction in computational complexity and enhanced accuracy for the proposed method, thereby providing valuable insights for improving adaptive long-term Wi-Fi indoor localization systems.

3.
Sensors (Basel) ; 24(17)2024 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-39275609

RESUMEN

Wi-Fi fingerprint indoor localization uses Wi-Fi signal strength measurements obtained from a number of access points. This method needs manual data collection across a positioning area and an annotation process to label locations to the measurement sets. To reduce the cost and effort, this paper proposes a Wi-Fi Semi-Supervised Generative Adversarial Network (SSGAN), which produces artificial but realistic trainable fingerprint data. The Wi-Fi SSGAN is based on a deep learning, which is extended from GAN in a semi-supervised learning manner. It is designed to create location-labeled Wi-Fi fingerprint data, which is different to unlabeled data generation by a normal GAN. Also, the proposed Wi-Fi SSGAN network includes a positioning model, so it does not need a external positioning method. When the Wi-Fi SSGAN is applied to a multi-story landmark localization, the experimental results demonstrate a 35% more accurate performance in comparison to a standard supervised deep neural network.

4.
Reprod Med Biol ; 23(1): e12606, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39263384

RESUMEN

Purpose: This study aimed to evaluate the protective effects of edible bird nest (EBN) against the detrimental impact of Wi-Fi on male reproductive health. Specifically, it examines whether EBN can mitigate Wi-Fi-induced changes in male reproductive hormones, estrogen receptors (ER), spermatogenesis, and sperm parameters. Methods: Thirty-six adult male rats were divided into six groups (n = 6): Control, Control EBN, Control E2, Wi-Fi, Wi-Fi+EBN, and Wi-Fi+E2. Control EBN and Wi-Fi+EBN groups received 250 mg/kg/day EBN, while Control E2 and Wi-Fi+E2 groups received 12 µg/kg/day E2 for 10 days. Wi-Fi exposure and EBN supplementation lasted eight weeks. Assessments included organ weight, hormone levels (FSH, LH, testosterone, and E2), ERα/ERß mRNA and protein expression, spermatogenic markers (c-KIT and SCF), and sperm quality. Results: Wi-Fi exposure led to decreased FSH, testosterone, ERα mRNA, and sperm quality (concentration, motility, and viability). EBN supplementation restored serum FSH and testosterone levels, increased serum LH levels, and the testosterone/E2 ratio, and normalized mRNA ERα expression. Additionally, EBN increased sperm concentration in Wi-Fi-exposed rats without affecting motility or viability. Conclusions: EBN plays a crucial role in regulating male reproductive hormones and spermatogenesis, leading to improved sperm concentration. This could notably benefit men experiencing oligospermia due to excessive Wi-Fi exposure.

5.
N Am Spine Soc J ; 19: 100531, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39286293

RESUMEN

Background: The aging spine often presents multifaceted surgical challenges for the surgeon because it can directly and indirectly impact a patient's spinal alignment and quality of life. Elderly and osteoporotic patients are predisposed to progressive spinal deformities and potential neurologic compromise and surgical management can be difficult because these patients often present with greater frailty. Methods: This was a literature review of spinal alignment changes, preoperative considerations, and spinal alignment considerations for surgical strategies. Results: Many factors impact spinal alignment as we age including lumbar lordosis flexibility, hip flexion, deformity, and osteoporosis. Preoperative considerations are required to assess the patient's overall health, bone mineral density, and osteoporosis medications. Careful radiographic assessment of the spinopelvic parameters using various classification/scoring systems provide the surgeon with goals for surgical treatment. An individualized surgical strategy can be planned for the patient including extent of surgery, surgical approach, extent of the constructs, fixation techniques, vertebral augmentation, ligamentous augmentation, and staging surgery. Conclusions: Surgical treatment should only be considered after a thorough assessment of the patient's health, deformity, bone quality and corresponding age matched alignment goals. An individualized treatment approach is often required to tackle the deformity and minimize the risk of hardware related complications and pseudarthrosis. Anabolic agents offer a promising benefit in this patient population by directly addressing and improving their bone quality and mineral density preoperatively and postoperatively.

6.
Nano Lett ; 2024 Sep 13.
Artículo en Inglés | MEDLINE | ID: mdl-39268850

RESUMEN

Advanced photodetectors are crucial for high-fidelity optical communication. However, the tradeoff between high external quantum efficiency (EQE) and high light fidelity (Li-Fi) frequency often limits data transmission accuracy and timeliness. Here, we report a photodetector consisting of lead sulfide (PbS) colloidal quantum dots (CQDs) with near-infrared responsiveness and perovskite frameworks responsible for the charge transport to overcome the EQE × Li-Fi constraint. Optimizing the PbS CQDs distribution and trap depth in the perovskite layer enhances charge injection, achieving a device gain of 11892% for 1200 nm photons and a response frequency of 24 kHz at -2 V. The device exhibits a record EQE × Li-Fi frequency product of 106 Hz. We have applied the detector to near-infrared optical communications at a data transfer rate of 2000 bits per second (2 kbps) to demonstrate the advances in high fidelity, the device retains over 98% of the original waveform information in its output.

7.
Exp Neurol ; 380: 114919, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39142370

RESUMEN

Oxidative stress can impair the endothelial barrier and thereby enable autoantibody migration in Neuromyelitis optica spectrum disorder (NMOSD). Tissue-specific vulnerability to autoantibody-mediated damage could be explained by a differential, tissue-dependent endothelial susceptibility to oxidative stress. In this study, we aim to investigate the barrier integrity and complement profiles of brain and retinal endothelial cells under oxygen-induced oxidative stress to address the question of whether the pathomechanism of NMOSD preferentially affects the brain or the retina. Primary human brain microvascular endothelial cells (HBMEC) and primary human retinal endothelial cells (HREC) were cultivated at different cell densities (2.5*104 to 2*105 cells/cm2) for real-time cell analysis. Both cell types were exposed to 100, 500 and 2500 µM H2O2. Immunostaining (CD31, VE-cadherin, ZO-1) and Western blot, as well as complement protein secretion using multiplex ELISA were performed. HBMEC and HREC cell growth phases were cell type-specific. While HBMEC cell growth could be categorized into an initial peak, proliferation phase, plateau phase, and barrier breakdown phase, HREC showed no proliferation phase, but entered the plateau phase immediately after an initial peak. The plateau phase was 7 h shorter in HREC. Both cell types displayed a short-term, dose-dependent adaptive response to H2O2. Remarkably, at 100 µM H2O2, the transcellular resistance of HBMEC exceeded that of untreated cells. 500 µM H2O2 exerted a more disruptive effect on the HBMEC transcellular resistance than on HREC. Both cell types secreted complement factors H (FH) and I (FI), with FH secretion remaining stable after 2 h, but FI secretion decreasing at higher H2O2 concentrations. The observed differences in resistance to oxidative stress between primary brain and retinal endothelial cells may have implications for further studies of NMOSD and other autoimmune diseases affecting the eye and brain. These findings may open novel perspectives for the understanding and treatment of such diseases.


Asunto(s)
Encéfalo , Células Endoteliales , Peróxido de Hidrógeno , Estrés Oxidativo , Retina , Humanos , Estrés Oxidativo/fisiología , Estrés Oxidativo/efectos de los fármacos , Células Endoteliales/metabolismo , Células Endoteliales/efectos de los fármacos , Retina/metabolismo , Encéfalo/metabolismo , Peróxido de Hidrógeno/farmacología , Células Cultivadas , Barrera Hematoencefálica/metabolismo , Barrera Hematoencefálica/efectos de los fármacos
8.
BMC Genom Data ; 25(1): 77, 2024 Aug 27.
Artículo en Inglés | MEDLINE | ID: mdl-39192187

RESUMEN

OBJECTIVES: Roscoea is a Sino-Himalayan alpine genus in pantropical family Zingiberaeae. As traditional Tibetan medicinal plants, many species of this genus are threatened by digging, logging, land clearance, grazing and climate change. Roscoea debilis is an endemic species in the Hengduan Mountains with a narrow distribution range. In this study, the assembled and annotated genome of Roscoea was presented in order to furnish significant resources for comparative and functional genomic investigations. The first complete reference genome of Roscoea is expected to shed light on research on conservation and evolutionary biology. DATA DESCRIPTION: A chromosome-level genome of 1601.04 Mb was obtained for R. debilis by combining Illumina short reads (107.28 Gb) and PacBio Hi-Fi reads (64.08 Gb), achieving high-quality sequencing coverage of roughly 67 × and 40 ×. The assembly was additionally assisted by 271.65 Gb Hi-C data (169 ×), which resulted in a contig N50 of 136.17 Mb and a scaffold N50 of 90.48 Mb. Benchmarking Universal Single-Copy Orthologs (BUSCO) assessment results revealed that most of the core embryophyta genes (98.7%) in the BUSCO dataset (embryophyta_odb10) were successfully identified. Additionally, 96.44% of the genomic sequences were accurately mapped onto twelve pseudochromosomes.


Asunto(s)
Genoma de Planta , Genoma de Planta/genética , Zingiberaceae/genética , Anotación de Secuencia Molecular , Secuenciación de Nucleótidos de Alto Rendimiento , Genómica/métodos , Filogenia
9.
Micromachines (Basel) ; 15(7)2024 Jun 29.
Artículo en Inglés | MEDLINE | ID: mdl-39064361

RESUMEN

A miniaturized and wideband four-port multiple-input multiple-output (MIMO) antenna pair for Wi-Fi mobile terminals application is proposed. The proposed antenna pair consists of four multi-branch antenna elements arranged orthogonally, with an overall size of 40 × 40 × 3.5 mm3 and each antenna element size of 15.2 × 3.5 mm × 0.8 mm3. The performance of the proposed antenna shows the advantages of a wide frequency band, low mutual coupling, high efficiency, and a compact structure. The wideband characteristics of the antenna elements are achieved through multi-mode resonance. The suppression of coupling is accomplished by strategically positioning the four compact antenna elements to ensure their maximum radiation directions are orthogonal, thus eliminating the need for an additional decoupling structure. In this paper, the proposed antenna is optimized in terms of the parameters then simulated and measured. The simulated results illustrate that an impedance bandwidth of the antenna is about 15% (5.06~5.88 GHz) with S11 < -10 dB, excellent port isolation exceeds 20 dB between all ports, a high radiation efficiency ranges from 51.2% to 89.9%, the maximum gain is 4.5 dBi, and the ECCs are less than 0.04. The measured results show that the -10 dB impedance bandwidth of the antenna is about 13% (5.13~5.80 GHz), the isolation between the antenna elements is better than 21 dB, the radiation efficiency ranges from 51.8% to 92.3%, the maximum gain is 5.3 dBi, and the ECCs are less than 0.05. The proposed four-port MIMO antenna works on the 5G LTE band 46 and Wi-Fi 6E operating bands. As a mobile terminal antenna, the proposed design scheme demonstrates excellent performance and applicability, fulfilling the requirements for 5G mobile terminal applications.

10.
Data Brief ; 55: 110673, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-39049967

RESUMEN

Human Activity Recognition (HAR) has emerged as a critical research area due to its extensive applications in various real-world domains. Numerous CSI-based datasets have been established to support the development and evaluation of advanced HAR algorithms. However, existing CSI-based HAR datasets are frequently limited by a dearth of complexity and diversity in the activities represented, hindering the design of robust HAR models. These limitations typically manifest as a narrow focus on a limited range of activities or the exclusion of factors influencing real-world CSI measurements. Consequently, the scarcity of diverse training data can impede the development of efficient HAR systems. To address the limitations of existing datasets, this paper introduces a novel dataset that captures spatial diversity through multiple transceiver orientations over a high dimensional space encompassing a large number of subcarriers. The dataset incorporates a wider range of real-world factors including extensive activity range, a spectrum of human movements (encompassing both micro-and macro-movements), variations in body composition, and diverse environmental conditions (noise and interference). The experiment is performed in a controlled laboratory environment with dimensions of 5 m (width) × 8 m (length) × 3 m (height) to capture CSI measurements for various human activities. Four ESP32-S3-DevKitC-1 devices, configured as transceiver pairs with unique Media Access Control (MAC) addresses, collect CSI data according to the Wi-Fi IEEE 802.11n standard. Mounted on tripods at a height of 1.5 m, the transmitter devices (powered by external power banks) positioned at north and east send multiple Wi-Fi beacons to their respective receivers (connected to laptops via USB for data collection) located at south and west. To capture multi-perspective CSI data, all six participants sequentially performed designated activities while standing in the centre of the tripod arrangement for 5 s per sample. The system collected approximately 300-450 packets per sample for approximately 1200 samples per activity, capturing CSI information across the 166 subcarriers employed in the Wi-Fi IEEE 802.11n standard. By leveraging the richness of this dataset, HAR researchers can develop more robust and generalizable CSI-based HAR models. Compared to traditional HAR approaches, these CSI-based models hold the promise of significantly enhanced accuracy and robustness when deployed in real-world scenarios. This stems from their ability to capture the nuanced dynamics of human movement through the analysis of wireless channel characteristic from different spatial variations (utilizing two-diagonal ESP32 transceivers configuration) with higher degree of dimensionality (166 subcarriers).

11.
J Microsc Ultrastruct ; 12(2): 51-61, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39006042

RESUMEN

Introduction: Electromagnetic radiation (EMR) is widely used nowadays in various fields due to rapid expansion of technology and affects different organs such as endocrine glands. Antioxidants protect the cells and act as a free radical scavenger. Aim of Work: The aim of the study was to clarify the effect of EMR emitted from Wi-Fi router on the thyroid gland of adult male albino rats and the possible protective role of combined Vitamin C and zinc. Materials and Methods: Thirty adult male albino rats were divided into three groups: Group I (control group), Group II (received combined Vitamin C and Zinc in one tablet called IMMUNO-MASH), and Group III (experimental groups). Group III was divided into two subgroups (A and B) according to the duration of exposure: 6 h and 24 h/day. Each of these groups was divided into two equal subgroups. One was exposed only to EMR while the other was exposed to EMR and received combined Vitamin C and zinc. All rats were weighed at the beginning and at the end of the experiment. The thyroid gland was prepared for general histological, anti-calcitonin immunostaining, and ultrastructural study. Furthermore, measurement of total serum T3, T4, and thyroid-stimulating hormone (TSH) hormone levels and quantitative analysis of immunoreactive C-cells were done. Then, statistical analysis was done on the number of immunoreactive C-cells, data of the body weight, and the hormonal levels. Results: A highly significant increase in the body weight in subgroups exposed to EMR for 24 h/day was observed. Furthermore, they showed a highly significant decline in T3 and T4 levels together with a highly significant increase in TSH level. With increasing period of exposure, there was a variable degree of deterioration in the form of congestion and dilatation of blood vessels, cellular infiltration, follicular disintegration, vacuolar degeneration, and desquamated follicular cells in the colloid. The C-cells showed a significant increase in the mean number compared with the control group. Ultrastructural analysis of follicular cells revealed colloid droplets, deteriorations in rough endoplasmic reticulum, degenerating nuclei, and swollen mitochondria according to the dose of exposure. There was apparent improvement with the use of combined Vitamin C and zinc. Conclusion: Wi-Fi radiation has a very serious effect on thyroid gland morphology and activity. Moreover, experimentally induced hypothyroidism by radiation resulted in increased C-cell number. Combined Vitamin C and zinc could have a protective role against this tissue damage.

12.
Environ Sci Pollut Res Int ; 31(34): 46965-46978, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38981962

RESUMEN

This study examines the connection between economic policy uncertainty (EPU), CO2 emissions, and financial inclusion in developed and developing countries. Using the data from 2004 to 2021, advanced statistical techniques are employed, including Sobel test, to explore the mediating effect of financial inclusion on the relationship between economic policy uncertainty (EPU) and CO2 emissions. There is a dearth of research examining these three variables together in a single study. Similarly, using financial inclusion as a mediator in the relation of EPU and CO2 emissions is a novel concept. This article employs a multi-indicator approach to measure key variables like CO2 emissions and financial inclusion. The results indicate that uncertainties in economic policies contribute in practices that lead to higher CO2 emissions in overall panel data of 44 countries. In addition, when considering the relationship between EPU and FI, the results indicate a significant and negative relationship between EPU and FI. If there is uncertainty in economic policies, it may lead toward challenges and hurdles in financial inclusion. When the mediating affect was checked, it was found financial inclusion acts as a significant mediator in the relationship between EPU and CO2 emissions, depicting that financial inclusion fosters the environmental quality and mitigates the potential harmful effects of environmental aspects of economic policy uncertainty. Therefore, policies that promote financial inclusion should be given top priority by governments, particularly in emerging nations. Financial literacy and bank service accessibility should be promoted. These measures would lessen the impact of staggering economic policies on CO2 emissions. It is necessary for policymakers to include environmental factors, specifically those relating to carbon emissions, into economic strategies. This requires encouraging industries to adopt eco-friendly practices and coordinating economic strategies with sustainability objectives.


Asunto(s)
Dióxido de Carbono , Dióxido de Carbono/análisis , Incertidumbre , Política Ambiental , Países en Desarrollo
13.
Microbiol Resour Announc ; 13(8): e0047624, 2024 Aug 13.
Artículo en Inglés | MEDLINE | ID: mdl-38953663

RESUMEN

Mycobacterium montefiorense, a nontuberculous mycobacterium, is a causative agent of mycobacteriosis in aquatic animals, its type strain M. montefiorense ATCC BAA-256 being isolated from a moray eel. In this study, we report the complete ATCC BAA-256 genome sequence with a 5,693,452-bp-containing circular chromosome, 65.2% GC content, and 5,407 coding sequences.

14.
Sensors (Basel) ; 24(11)2024 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-38894257

RESUMEN

In the face of rising population, erratic climate, resource depletion, and increased exposure to natural hazards, environmental monitoring is increasingly important. Satellite data form most of our observations of Earth. On-the-ground observations based on in situ sensor systems are crucial for these remote measurements to be dependable. Providing open-source options to rapidly prototype environmental datalogging systems allows quick advancement of research and monitoring programs. This paper introduces Loom, a development environment for low-power Arduino-programmable microcontrollers. Loom accommodates a range of integrated components including sensors, various datalogging formats, internet connectivity (including Wi-Fi and 4G Long Term Evolution (LTE)), radio telemetry, timing mechanisms, debugging information, and power conservation functions. Additionally, Loom includes unique applications for science, technology, engineering, and mathematics (STEM) education. By establishing modular, reconfigurable, and extensible functionality across components, Loom reduces development time for prototyping new systems. Bug fixes and optimizations achieved in one project benefit all projects that use Loom, enhancing efficiency. Although not a one-size-fits-all solution, this approach has empowered a small group of developers to support larger multidisciplinary teams designing diverse environmental sensing applications for water, soil, atmosphere, agriculture, environmental hazards, scientific monitoring, and education. This paper not only outlines the system design but also discusses alternative approaches explored and key decision points in Loom's development.

15.
Sensors (Basel) ; 24(11)2024 Jun 04.
Artículo en Inglés | MEDLINE | ID: mdl-38894433

RESUMEN

Multi-link operation (MLO) is a new and essential mechanism of IEEE 802.11be Extremely High Throughput (Wi-Fi 7) that can increase throughput and decrease latency in Wireless Local Area Networks (WLANs). The MLO enables a Multi-Link Device (MLD) to perform Simultaneous Transmission and Reception (STR) in different frequency bands. However, not all MLDs can support STR due to cross-link or in-device coexistence interference, while an STR-unable MLD (NSTR-MLD) can transmit multiple frames simultaneously in more than two links. This study focuses on the problems when NSTR-MLDs share a link with Single-Link Devices (SLDs). We propose a Contention-Less Synchronous Transmission (CLST) mechanism to improve fairness between NSTR-MLDs and SLDs while increasing the total network throughput. The proposed mechanism classifies links as MLD Dominant Links (MDLs) and Heterogeneous Coexistence Links (HCLs). In the proposed mechanism, an NSTR-MLD obtains a Synchronous Transmission Token (STT) through a virtual channel contention in the HCL but does not actually transmit a frame in the HCL, which is compensated for by a synchronous transmission triggered in the MDL. Moreover, the CLST mechanism allows additional subsequent transmissions up to the accumulated STT without further contention. Extensive simulation results confirm the outstanding performance of the CLST mechanism in terms of total throughput and fairness compared to existing synchronous transmission mechanisms.

16.
Sensors (Basel) ; 24(12)2024 Jun 13.
Artículo en Inglés | MEDLINE | ID: mdl-38931610

RESUMEN

Large-scale multi-building and multi-floor indoor localization has recently been the focus of intense research in indoor localization based on Wi-Fi fingerprinting. Although significant progress has been made in developing indoor localization algorithms, few studies are dedicated to the critical issues of using existing and constructing new Wi-Fi fingerprint databases, especially for large-scale multi-building and multi-floor indoor localization. In this paper, we first identify the challenges in using and constructing Wi-Fi fingerprint databases for large-scale multi-building and multi-floor indoor localization and then provide our recommendations for those challenges based on a case study of the UJIIndoorLoc database, which is the most popular publicly available Wi-Fi fingerprint multi-building and multi-floor database. Through the case study, we investigate its statistical characteristics with a focus on the three aspects of (1) the properties of detected wireless access points, (2) the number, distribution and quality of labels, and (3) the composition of the database records. We then identify potential issues and ways to address them using the UJIIndoorLoc database. Based on the results from the case study, we not only provide valuable insights on the use of existing databases but also give important directions for the design and construction of new databases for large-scale multi-building and multi-floor indoor localization in the future.

17.
Age Ageing ; 53(5)2024 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-38752921

RESUMEN

OBJECTIVE: To investigate longitudinal associations between variations in the co-expression-based brain insulin receptor polygenic risk score and frailty, as well as change in frailty across follow-up. METHODS: This longitudinal study included 1605 participants from the Helsinki Birth Cohort Study. Biologically informed expression-based polygenic risk scores for the insulin receptor gene network, which measure genetic variation in the function of the insulin receptor, were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions. Frailty was assessed in at baseline in 2001-2004, 2011-2013 and 2017-2018 by applying a deficit accumulation-based frailty index. Analyses were carried out by applying linear mixed models and logistical regression models adjusted for adult socioeconomic status, birthweight, smoking and their interactions with age. RESULTS: The FI levels of women were 1.19%-points (95% CI 0.12-2.26, P = 0.029) higher than in men. Both categorical and continuous hePRS-IR in women were associated with higher FI levels than in men at baseline (P < 0.05). In women with high hePRS-IR, the rate of change was steeper with increasing age compared to those with low or moderate hePRS-IR (P < 0.05). No associations were detected between mePRS-IR and frailty at baseline, nor between mePRS-IR and the increase in mean FI levels per year in either sex (P > 0.43). CONCLUSIONS: Higher variation in the function of the insulin receptor gene network in the hippocampus is associated with increasing frailty in women. This could potentially offer novel targets for future drug development aimed at frailty and ageing.


Asunto(s)
Fragilidad , Redes Reguladoras de Genes , Receptor de Insulina , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Edad , Envejecimiento/genética , Antígenos CD , Encéfalo/metabolismo , Finlandia , Fragilidad/genética , Fragilidad/diagnóstico , Evaluación Geriátrica , Hipocampo/metabolismo , Estudios Longitudinales , Receptor de Insulina/genética , Receptor de Insulina/metabolismo , Factores de Riesgo , Factores Sexuales
18.
Sensors (Basel) ; 24(10)2024 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-38793999

RESUMEN

The complexity and the criticality of automotive electronic implanted systems are steadily advancing and that is especially the case for automotive software development. ISO 26262 describes requirements for the development process to confirm the safety of such complex systems. Among these requirements, fault injection is a reliable technique to assess the effectiveness of safety mechanisms and verify the correct implementation of the safety requirements. However, the method of injecting the fault in the system under test in many cases is still manual and depends on an expert, requiring a high level of knowledge of the system. In complex systems, it consumes time, is difficult to execute, and takes effort, because the testers limit the fault injection experiments and inject the minimum number of possible test cases. Fault injection enables testers to identify and address potential issues with a system under test before they become actual problems. In the automotive industry, failures can have serious hazards. In these systems, it is essential to ensure that the system can operate safely even in the presence of faults. We propose an approach using natural language processing (NLP) technologies to automatically derive the fault test cases from the functional safety requirements (FSRs) and execute them automatically by hardware-in-the-loop (HIL) in real time according to the black-box concept and the ISO 26262 standard. The approach demonstrates effectiveness in automatically identifying fault injection locations and conditions, simplifying the testing process, and providing a scalable solution for various safety-critical systems.

19.
Sci Total Environ ; 932: 172929, 2024 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-38703852

RESUMEN

Firework (FW) events occur during various festivals worldwide and substantially negatively influence both air quality and human health. However, the effects of FWs on the chemical properties and formation of organic aerosols are far from clear. In this study, fine particulate matter (PM2.5) samples were collected in a suburban area in Qingdao, China during the Chinese Spring Festival. The concentrations of chemical species (especially carbonaceous components) in PM2.5 were measured using a combination of several state-of-the-art techniques. Our results showed that mass concentrations of water-soluble sulfate, potassium and chloride ions, and organic carbon drastically increased and became the predominant components in PM2.5 during FW events. Correspondingly, both the number and fractional contributions of sulfur (S)-containing subgroups (e.g., CHOS and CHONS compounds) and some chlorine (Cl)-containing organic (e.g., CHOSCl and CHONSCl) compounds identified using ultrahigh-resolution Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) increased. The S- and Cl-containing compounds unique to the FW display period were identified, and their chemical characterization, sources, and formation mechanisms were elucidated by combining FT-ICR MS and quantum chemical calculations. Our results suggest that FW emissions play notable roles in both primary and secondary organic aerosol formation, especially for CHOS- and Cl-containing organic compounds.

20.
Sensors (Basel) ; 24(9)2024 Apr 29.
Artículo en Inglés | MEDLINE | ID: mdl-38732949

RESUMEN

With the escalating demand for Radio Frequency Identification (RFID) technology and the Internet of Things (IoT), there is a growing need for sustainable and autonomous power solutions to energize low-powered devices. Consequently, there is a critical imperative to mitigate dependency on batteries during passive operation. This paper proposes the conceptual framework of rectenna architecture-based radio frequency energy harvesters' performance, specifically optimized for low-power device applications. The proposed prototype utilizes the surroundings' Wi-Fi signals within the 2.4 GHz frequency band. The design integrates a seven-stage Cockroft-Walton rectifier featuring a Schottky diode HSMS286C and MA4E2054B1-1146T, a low-pass filter, and a fractal antenna. Preliminary simulations conducted using Advanced Design System (ADS) reveal that a voltage of 3.53 V can be harvested by employing a 1.57 mm thickness Rogers 5880 printed circuit board (PCB) substrate with an MA4E2054B1-1146T rectifier prototype, given a minimum power input of -10 dBm (0.1 mW). Integrating the fabricated rectifier and fractal antenna successfully yields a 1.5 V DC output from Wi-Fi signals, demonstrable by illuminating a red LED. These findings underscore the viability of deploying a fractal antenna-based radio frequency (RF) harvester for empowering small electronic devices.

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