RESUMEN
2D materials have shown great potential as electrode materials that determine the performance of a range of electrochemical energy technologies. Among these, 2D copper-based materials, such as Cu-O, Cu-S, Cu-Se, Cu-N, and Cu-P, have attracted tremendous research interest, because of the combination of remarkable properties, such as low cost, excellent chemical stability, facile fabrication, and significant electrochemical properties. Herein, the recent advances in the emerging 2D copper-based materials are summarized. A brief summary of the crystal structures and synthetic methods is started, and innovative strategies for improving electrochemical performances of 2D copper-based materials are described in detail through defect engineering, heterostructure construction, and surface functionalization. Furthermore, their state-of-the-art applications in electrochemical energy storage including supercapacitors (SCs), alkali (Li, Na, and K)-ion batteries, multivalent metal (Mg and Al)-ion batteries, and hybrid Mg/Li-ion batteries are described. In addition, the electrocatalysis applications of 2D copper-based materials in metal-air batteries, water-splitting, and CO2 reduction reaction (CO2 RR) are also discussed. This review also discusses the charge storage mechanisms of 2D copper-based materials by various advanced characterization techniques. The review with a perspective of the current challenges and research outlook of such 2D copper-based materials for high-performance energy storage and conversion applications is concluded.
RESUMEN
In this work, we developed a novel label-free and highly sensitive electrochemical (EC) biosensor for detection of microRNA (miRNA), which was based on the target-triggered and the Cu-based metal-organic frameworks (Cu-MOFs) mediated CHA-HCR dual-amplification process. Initially, the target miRNA triggered the catalytic hairpin assembly (CHA) process of hairpin DNA 1 (H1) and hairpin DNA 2 (H2) to produce massive double-stranded DNA (H1/H2) which could hybridize with the single-stranded DNA 1 (P1) to form capture probe (P1/H1/H2) on electrode surface, realizing the first amplification of input signals. Subsequently, hybridization chain reaction (HCR) between signal probe (H3-AuNPs/Cu-MOFs) and hairpin DNA 4 (H4) was activated by above capture probe (P1/H1/H2), leading to the second amplification of input signals. After the HCR process, numerous Cu-MOFs were immobilized on the electrode surface, which brought out the enhancement of electrochemical signals generating by Cu-MOFs. Herein, Cu-MOFs not only offered the lager surface area to decorate with gold nanoparticles (AuNPs) and hairpin DNA 3 (H3), but also served as the signal probe (H3-AuNPs/Cu-MOFs) to produce electrochemical signals by hybridizing with the capture probe on electrode surface. Therefore, the ingenious design of CHA-HCR-Cu-MOFs scheme enables the sensitive analysis of microRNA-21 (miR-21) with a broad linear range from 0.1 fM to 100 pM and a lower LOD of 0.02 fM. In addition, the outstanding specificity of this sensing strategy allows it successfully to be applied for determining miR-21 in real biological samples.