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Application of chemical acaricides in the control of ticks has led to the problem of tick-acaricide control failure. To obtain an understanding of the possible risk factors involved in this tick-acaricide control failure, this study investigated tick control practices on communal farms in the north-eastern part of the Eastern Cape Province (ECP) of South Africa. A semi-structured questionnaire designed to document specific farm attributes and acaricide usage practices was administered at 94 communal farms from the Oliver Tambo District municipality of the ECP. Data collected indicated that the main acaricide chemicals used at plunge dips of inland and coastal areas were synthetic pyrethroid formulations. Most (75%) farmers claimed not to have noticed a significant reduction in numbers of actively feeding and growing ticks on cattle after several acaricide treatments. Based on the farmers' perceptions, leading factors that could have led to tick-acaricide control failure included: weak strength of the dip solution (76%); poor structural state of dip tanks (42%); and irregular tick control (21%). The rearing of crossbreeds of local and exotic cattle breeds, perceived weak strength of the dip solution and high frequency of acaricide treatment, were statistically associated with proportions of farms reporting tick-acaricide control failure. Furthermore, approximately 50% of farms reported at least four tick control malpractices, which could have resulted in the emergence and spread of tick-acaricide control failure. Other sub-optimal tick control practices encountered included incorrect acaricide rotation, and failure to treat all cattle in a herd. This data will inform and guide the development of management strategies for tick-acaricide control failure and resistance in communal farming areas.

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This longitudinal study used a person-centered approach to differentiate fear of missing out (FoMO) among subgroups of individuals using latent profile analysis (LPA). The subgroups were identified according to trait-FoMO (a specific predisposition) and state-FoMO (a specific cognition in the online context) items. Data were collected from 1125 participants (70.04 % female, age range 17-26 years, Mage = 20.52 years). The LPA showed five distinct profiles: highest FoMO, high trait-FoMO high state-FoMO, high trait-FoMO low state-FoMO, low trait-FoMO high state-FoMO, and low trait-FoMO low state-FoMO. We further explored how these profiles relate to social media use. The results revealed significant differences between profiles in terms of social media engagement, social media self-control failure, and problematic social media use and could be used to predict social media use behaviors of 437 participants (77.35 % female, age range 18-27 years, Mage = 20.60 years) six months later. Thus, the combination of high trait-FoMO and high state-FoMO may mean more frequent social media engagement and could be an important risk factor for social media self-control failure and problematic social media use. Additionally, state-FoMO should be considered in prevention and intervention strategies aimed at addressing young adults' problematic social media use.

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BACKGROUND: Spodoptera frugiperda (J. E. Smith) is a widespread agricultural pest with several records of resistance to different insecticides and Bt proteins, including the neurotoxic insecticides chlorpyrifos (organophosphate) and lambda-cyhalothrin (pyrethroid). Here, we (i) characterized and monitored the susceptibility of field populations of S. frugiperda to chlorpyrifos (194 populations) and lambda-cyhalothrin (197 populations) collected from major maize-growing regions of Brazil from 2003 to 2016, and (ii) compared gene expression levels of laboratory-selected, chlorpyrifos- and lambda-cyhalothrin-resistant strains to a susceptible reference strain (Sf-ss) of S. frugiperda. RESULTS: The susceptibility monitoring detected average survival ranging from 29.3% to 36.0% for chlorpyrifos, and 23.1% to 68.0% for lambda-cyhalothrin. The resistance ratio of the chlorpyrifos-resistant strain (Clo-rr) was 25.4-fold and of the lambda-cyhalothrin-resistant strain (Lam-rr) was 21.5-fold. We identified 1098 differentially expressed genes (DEGs) between Clo-rr and Sf-ss, and 303 DEGs between Lam-rr and Sf-ss. Functional analyses of the DEGs revealed the up-regulation of several detoxification enzymes, mainly cytochrome P450 belonging to CYP3 and CYP6 clans. Genes associated with regulatory processes, such as the forkhead box class O (FoxO) transcription factor were also up-regulated. Variant analysis of target-site mutations for both pesticides identified the A201S and F290V mutations in acetylcholinesterase-1, both occurring in heterozigosis in the Clo-rr S. frugiperda strain. CONCLUSION: Our data show that the overexpression of the enzymatic detoxification machinery is the main difference to explain the resistance of Clo-rr and Lam-rr strains of S. frugiperda to chlorpyrifos and lambda-cyhalothrin, although a target-site mutation also contributes to the Clo-rr resistance to chlorpyrifos. © 2023 Society of Chemical Industry.

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Social networking site smartphone applications have been widely used among Chinese young adults. However, less is known about their effects on emotional health and the mechanisms through which they function. This study analyzes the relationship between college students' smartphone social networking service use patterns, social gratification, social media self-control failure, and emotional health. Data was collected from 360 college students in China via application log tracking and a self-administered questionnaire. Structural equation modeling results showed that, after controlling for demographic variables, the use of video social networking site smartphone applications was associated with decreased social gratification, and ultimately, adverse emotional health. Using social networking site smartphone applications late at night exhibited worse emotional health via more social media self-control failure. The implications for designing and using social media applications are discussed.

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Exerting effort in a first task can impair self-control performance in a subsequent task. Hundreds of studies have examined this ego depletion effect, but the underlying mechanisms are still unknown. By contrasting the two most prominent models, the strength model and the process model, the following question takes centre stage: Do participants fail to exert self-control because they run short of an unspecified resource or because they lack the motivation to engage in the subsequent task? We contrasted competing predictions (N = 560) from these two models by manipulating monetary incentives to be donated to charity in the first of two tasks. We found evidence of the standard ego depletion effect-self-control performance was impaired after a high- versus a low-demand task in the no-incentive conditions. Incentives had an unexpected effect: Whereas participants in the incentive conditions showed higher intrinsic, autonomous motivation, they did not exert greater effort. This unexpected finding limited the applicability of our registered predictions; thus, we opted to test updated predictions. We discuss the theoretical implications of our understanding of the processes underlying ego depletion effects and their meaning for the ongoing debate about replicability and robustness.

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With the increasing prevalence of mobile phone addiction, mobile phone addiction has been considered a prominent risk factor for internalizing or externalizing problems, such as psychological distress and irrational procrastination. However, few studies shed light on the effect of mobile phone addiction on mind wandering and the underlying mechanisms. This study speculated that the direct effect of mobile phone addiction on mind wandering may be linked to fatigue and that the level of an individual's personality characteristics, such as rumination, may influence both the direct and indirect effects of mobile phone addiction on mind wandering. To test these hypotheses, we recruited 1811 college students to complete the self-report questionnaires. The results indicated that mobile phone addiction was positively associated with mind wandering. This direct effect could be mediated by fatigue, and both the direct and indirect effects of mobile phone addiction on mind wandering could be moderated by rumination. Specifically, both the direct and indirect effects were stronger for students with high rumination. These findings enrich our understanding of how, why, and for whom mobile phone addiction is correlated with mind wandering.

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The status of insecticide resistance levels is important for applying suitable pest management approaches. The present study investigated the insecticide resistance of Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae) populations from five major cruciferous growing areas in Taiwan. The surveyed locations were distributed from central to southern Taiwan and included Taichung, Changhua, Yunlin, Chiayi, and Kaohsiung. High levels of resistance to spinosad, indoxacarb, metaflumizone, and chlorantraniliprole were recorded among the surveyed populations except in Taichung. The resistance ratios ranged from 2.376 to 1,236-fold for spinosad and 24.63-1,511-fold for indoxacarb. Similarly, those for metaflumizone and chlorantraniliprole, were 2.563-76.21- and 4.457-683.0-fold, respectively. However, Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki, emamectin benzoate, and diafenthiuron were still relatively effective against most field populations of P. xylostella. After approximately 10 generations of being maintained in the laboratory without exposure to insecticides, the resistance ratios of the Kaohsiung and Changhua populations declined to approximately 1.4-10-fold, and insecticides with control failure likelihood also began to show a negligible risk of control failure. Although spinosad, indoxacarb, metaflumizone, and chlorantraniliprole have lost their effectiveness in most field populations of P. xylostella in Taiwan, their effectiveness may be recovered in the absence of insecticide-selection pressure for approximately 10 generations. Therefore, we suggest that a constant survey of insecticide resistance and well-designed insecticide rotation based on the survey results are necessary for the effective control and insecticide resistance management of P. xylostella.

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Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scab.

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PURPOSE: Predicting the response to chemoradiotherapy is critical for the optimal management of esophageal cancer; however, it remains an unmet clinical need. This study aimed to evaluate the predictive potential of peri-treatment peripheral blood cells (PBC) in disease progression hazard in esophageal cancer following chemoradiotherapy. PATIENTS AND METHODS: A total of 87 patients with primary esophageal squamous cell carcinoma were subjected to definitive concurrent chemoradiotherapy in a Phase II trial. PBC parameters (hemoglobin, neutrophils, platelets, lymphocytes, and monocytes) were collected at seven time points throughout the course of radiotherapy. The potential of peri-treatment PBC parameters to predict the 3-year cumulative hazard of tumor progression was evaluated. RESULTS: Patients with disease progression displayed distinct distribution patterns of peri-treatment PBC compared to that in patients without disease progression. Greater prediction capabilities for risk of locoregional disease progression were found in PBC collected after the start of radiotherapy compared to those in their pretreatment counterparts, and in individual parameters rather than cell-to-cell ratios. The most predictive PBC parameters were integrated by summation and designated as a PBC score (PBCS), which further augmented their predictive power. Patients classified according to their PBCS (high vs medium v. low) had significantly different 3-year cumulative hazards of locoregional progression (58% vs 29% vs 7%, P = 0.0017). Multivariate analysis confirmed that high PBCS (HR, 12.2; 95% CI, 2.0-76.3; P = 0.007) and medium (HR, 5.8; 95% CI 1.2-27.7; P = 0.028) were independent indicators of locoregional progression. CONCLUSION: Systematic analysis of PBC distribution in esophageal cancer patients undergoing definitive chemoradiotherapy could help predict long-term locoregional progression hazard after treatment.

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Although surveys of pest populations documenting evolved insecticide resistance often suggest abundant potential for insecticide control failures, studies documenting the actual occurrence of such failures in commercial agriculture are rare. If farmers currently practice adaptive management, abandoning the use of insecticides once resistance emerges, actual control failures could be rare. Here I use data gathered by independent pest management consultants to describe a case study of the realized efficacy of commercial field applications of insecticides, examining the control of Lygus hesperus Knight on cotton. On average, insecticides reduced target pest populations to 19% of their preapplication densities. Short-term efficacy of insecticides was variable, but only one severe control failure was observed (1 of 50, 2%). The rarity of severe control failures observed in this study is in agreement with the few other studies conducted in commercial settings, but additional research is needed to assess the generality of this result. Although pesticides can cause longer-term problems, including target pest resurgences and secondary pest outbreaks, risk-averse attitudes among farmers coupled with relatively consistent short-term insecticide efficacy may be potent forces propelling farmers toward the use of insecticides.

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OBJECTIVE: To investigate trends in the prevalence of hypertension and dyslipidaemia in incident type 2 diabetes (T2DM), time to antihypertensive (AHT) and lipid-lowering therapy (LLT), and the association with systolic blood pressure (SBP) and lipid control. RESEARCH DESIGN AND METHODS: Using The Health Improvement Network UK primary care database, 254 925 people with incident T2DM and existing dyslipidaemia or hypertension were identified. Among those without atherosclerotic cardiovascular disease (ASCVD) history and not on AHT or LLT at diagnosis, the adjusted median months to initiating an AHT or an LLT, and the probabilities of high SBP or lipid levels over 2 years in people initiating therapy within or after 1 year were evaluated according to high and low ASCVD risk status. RESULTS: At diabetes diagnosis, 66% and 66% had dyslipidaemia and hypertension, respectively. During 2005 to 2016, dyslipidaemia prevalence increased by 10% in people aged <60 years, while hypertension prevalence remained stable in all age groups. Among those with high ASCVD risk status in the age groups 18 to 39, 40 to 49, and 50 to 59 years, the median number of months to initiation of therapy were 20.4 (95% confidence interval [CI] 20.3-20.5), 10.9 (95% CI 10.8-11.0), and 9.5 (95% CI 9.4-9.6) in the dyslipidaemia subcohort, and 28.1 (95% CI 28.0-28.2), 19.2 (95% CI 19.1-19.3), and 19.9 (95% CI 19.8-20.0) in the hypertension subcohort. Among people with high and low ASCVD risk status, respectively, compared to early LLT initiators, those who initiated LLT after 1 year had a 65.3% to 85.3% and a 65.0% to 85.3% significantly higher probability of failing lipid control at 2 years of follow-up, while late AHT initiators had a 46.5% to 57.9% and a 40.0% to 58.7% significantly higher probability of failing SBP control. CONCLUSIONS: Significant delay in initiating cardioprotective therapies was observed, and time to first prescription was similar in the primary prevention setting, irrespective of ASCVD risk status across all T2DM diagnosis age groups, resulting in poor risk factor control at 2 years of follow-up.

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How do people learn when to allocate how much cognitive control to which task? According to the Learned Value of Control (LVOC) model, people learn to predict the value of alternative control allocations from features of a situation. This suggests that people may generalize the value of control learned in one situation to others with shared features, even when demands for control are different. This makes the intriguing prediction that what a person learned in one setting could cause them to misestimate the need for, and potentially overexert, control in another setting, even if this harms their performance. To test this prediction, we had participants perform a novel variant of the Stroop task in which, on each trial, they could choose to either name the color (more control-demanding) or read the word (more automatic). Only one of these tasks was rewarded each trial and could be predicted by one or more stimulus features (the color and/or word). Participants first learned colors and then words that predicted the rewarded task. Then, we tested how these learned feature associations transferred to novel stimuli with some overlapping features. The stimulus-task-reward associations were designed so that for certain combinations of stimuli, transfer of learned feature associations would incorrectly predict that more highly rewarded task would be color-naming, even though the actually rewarded task was word-reading and therefore did not require engaging control. Our results demonstrated that participants overexerted control for these stimuli, providing support for the feature-based learning mechanism described by the LVOC model.

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Mosquito-borne malaria kills 429,000 people each year with the problem being acute in sub-Saharan Africa. The successes gained with long-lasting pyrethroid-treated bednets are now in jeopardy because of wide-spread, pyrethroid resistance in mosquitoes. Using crowd modeling theory normalized for standard bednet architecture, we were able to design an attract-trap-kill technology for mosquitoes that does not require insecticides. Using three-dimensional polyester knitting and heat fixation, trap funnels were developed with high capture efficacy with no egression under worst-case laboratory conditions. Field testing in Africa in WHO huts with Gen1-3 T (trap)-Nets validated our model, and as predicted, Gen3 had the highest efficacy with a 4.3-fold greater trap-kill rate with no deterrence or repellency compared to Permanet 2.0, the most common bednet in Africa. A T-Net population model was developed based on field data to predict community-level mosquito control compared to a pyrethroid bednet. This model showed the Gen3 non-insecticidal T-Net under field conditions in Africa against pyrethroid resistant mosquitoes was 12.7-fold more efficacious than single chemical, pyrethroid-treated nets.

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Intra-abdominal infection (IAI) is a deadly condition in which the outcome is associated with urgent diagnosis, assessment and management, including fluid resuscitation, antibiotic administration while obtaining further laboratory results, attaining precise measurements of hemodynamic status, and pursuing source control. This last item makes abdominal sepsis a unique treatment challenge. Delayed or inadequate source control is an independent predictor of poor outcomes and recognizing source control failure is often difficult or impossible. Further complicating issue in the debate is surrounding the timing, adequacy, and procedures of source control. This review evaluated and summarized the current approach and challenges in IAI management, which are the future research directions.

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We consider a minimalist model for the Sterile Insect Technique (SIT), assuming that residual fertility can occur in the sterile male population. Taking into account that we are able to get regular measurements from the biological system along the control duration, such as the size of the wild insect population, we study different control strategies that involve either continuous or periodic impulsive releases. We show that a combination of open-loop control with constant large releases and closed-loop nonlinear control, i.e., when releases are adjusted according to the wild population size estimates, leads to the best strategy in terms of both number of releases and total quantity of sterile males to be released. Last but not least, we show that SIT can be successful only if the residual fertility is less than a threshold value that depends on the wild population biological parameters. However, even for small values, the residual fertility induces the use of such large releases that SIT alone is not always reasonable from a practical point of view and thus requires to be combined with other control tools. We provide applications against a mosquito species, Aedes albopictus, and a fruit fly, Bactrocera dorsalis, and discuss the possibility of using SIT when residual fertility among the sterile males, can occur.

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Cyantraniliprole was recently registered for controlling the coffee berry borer Hypothenemus hampei, the main coffee pest in the world. In this study, baseline determination and resistance monitoring to cyantraniliprole were carried out in Brazilian populations of H. hampei. Evaluations were carried out for three years with representative field-collected populations from nine coffee-producing states in Brazil, using artificial diet containing the insecticide. The likelihood of control failure due to cyantraniliprole resistance was also determined. Populations from Campo do Meio, Linhares and Jaú were more susceptible (<2-fold resistance) to cyantraniliprole than populations from Patrocínio and Londrina (17-fold). Nonetheless, the frequency of cyantraniliprole resistance insects was low and not significant throughout the regions survey and the likelihood of control failure was negligible. Therefore, cyantraniliprole remains an important management tool against the coffee berry borer without current problems of control failure. However, enough field variation in susceptibility to cyantraniliprole exists justifying attention and careful management of this insecticide to prevent quick development of insecticide resistance in populations of this insect pest species.

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BACKGROUND: Pesticide resistance is a growing issue worldwide, and susceptibility of pest populations should be monitored in migratory intersection regions for successful resistance management. We determined the susceptibility of eight noctuid species from the Florida Panhandle to bifenthrin (pyrethroid) and chlorantraniliprole (diamide). Larvae from field and laboratory populations were exposed to commercial insecticide formulations using the leaf-dip method in concentration-mortality bioassays. RESULTS: The field populations of Helicoverpa zea (Boddie), Spodoptera frugiperda (Smith), S. eridania (Stoll), S. exigua (Hubner) and Chloridea virescens (Fabricius) had reduced susceptibility to bifenthrin compared with the laboratory populations. Resistance ratios to bifenthrin were as high as 10 071-fold in S. exigua and 436-fold in S. frugiperda, while there was no reduced susceptibility in Agrotis ipsilon (Hufnagel). The susceptibility to chlorantraniliprole was similar between the field and laboratory populations studied, except for S. exigua that exhibited 630-fold resistance to the diamide. The probit regression equations indicated that the larval mortality of S. exigua and S. frugiperda populations was <80% with bifenthrin at the concentration equivalent to the label rate. Likewise, the estimated mortality of S. exigua larvae with chlorantraniliprole at the label rate concentration was <80%. CONCLUSIONS: The lepidopteran pest populations tested were variable in susceptibility to bifenthrin by contrast to more consistent susceptibility to chlorantraniliprole. These results help in the choice of effective insecticides for integrated pest management and resistance management in cropping systems colonized by migratory lepidopteran pests from the U.S. Gulf Coast region. © 2020 Society of Chemical Industry.

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The Neotropical coffee leaf miner, Leucoptera coffeella (Guérin-Mèneville & Perrottet, 1842), is a key pest species of unshaded coffee plantations in Neotropical America, particularly in Brazil, where pest management involves intensive insecticide use. As a consequence, problems of resistance to conventional insecticides are frequent, and more recently developed insecticide molecules, such as diamide insecticides, are at risk of becoming ineffective. Thus, a survey of resistance to the diamide insecticide chlorantraniliprole was carried out in high-yield coffee-producing areas in the State of Bahia, Brazil. The likelihood of control failure with this insecticide was also assessed. Spatial dependence among the insect sampling sites was assessed and spatial mapping of chlorantraniliprole resistance and risk of control failure was carried out. The frequency of chlorantraniliprole resistant populations was high (34 out of 40 populations, or 85%), particularly in western Bahia, where 94% of the populations were resistant. Resistance levels ranged from low (<10-fold) to moderate (between 10- and 40-fold) with more serious instances occurring in western Bahia. This results in lower chlorantraniliprole efficacy among these populations, with a higher risk of control failure and exhibiting spatial dependence. These findings invite attention to problems with the intensive use of this relatively recent insecticide and demand management attention, but they suggest that local, farm-based management efforts are likely to be the most effective actions against resistance problems in this pest species.

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Obesity among children and adolescents has dramatically increased over the past two to three decades and is now a major public health issue. During this same period, youth exposure to media devices also became increasingly prevalent. Here, we present the novel hypothesis that media multitasking (MMT)-the simultaneous use of and switching between unrelated forms of digital media-is associated with an imbalance between regulatory processes and reward-related responses to appetitive food stimuli, resulting in a greater sensitivity to external food cues among high media multitaskers. This, in turn, may contribute to overeating and weight gain over time. To test this hypothesis, we conducted two studies examining research participants who grew up during the recent period of escalating multitasking and obesity-and among whom 37% are overweight or obese. In Study 1, participants' propensity to engage in MMT behaviors was associated with a higher risk for obesity (as indicated by higher body mass index and body fat percentage). Next, in Study 2, a subset of participants from Study 1 were exposed to appetitive food cues while undergoing functional neuroimaging and then, using passive mobile sensing, the time participants spent in various food points-of-sale over an academic term was inferred from GPS coordinates of their mobile device. Study 2 revealed that MMT was associated with an altered pattern of brain activity in response to appetizing food cues, specifically an imbalance favoring reward-related activity in ventral striatum and orbitofrontal cortex-relative to recruitment of the frontoparietal control network. This relationship was further tested in a mediation model, whereby increased MMT, via a brain imbalance favoring reward over control, was associated with greater time spent in campus eateries. Taken together, findings from both studies suggest the possibility that media multitasking may be implicated in the recent obesity epidemic.

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Intra-abdominal infection (IAI) is a deadly condition in which the outcome is associated with urgent diagnosis, assessment and management, including fluid resuscitation, antibiotic administration while obtaining further laboratory results, attaining precise measurements of hemodynamic status, and pursuing source control. This last item makes abdominal sepsis a unique treatment challenge. Delayed or inadequate source control is an independent predictor of poor outcomes and recognizing source control failure is often difficult or impossible. Further complicating issue in the debate is surrounding the timing, adequacy, and procedures of source control. This review evaluated and summarized the current approach and challenges in IAI management, which are the future research directions.

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