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Background and Objectives: Vulvovaginal infections pose significant health challenges for women, necessitating effective treatment approaches. This retrospective observational study aimed at investigating the efficacy of collagen-based vaginal ovules therapy, specifically Plurigin Ovules, in restoring cervical epithelialization and reducing inflammation in mycotic, viral, and bacterial cervico-vaginitis. Materials and Methods: A total of 398 women with cervico-vaginitis were included in the study, categorized into three groups: bacterial cervico-vaginitis (Group A), viral cervico-vaginitis (Group B), and fungal cervico-vaginitis (Group C). Participants received vaginal therapy with Plurigin Ovules for three months. Vaginal health parameters were assessed at baseline (T0) and after six months (T1) using various diagnostic tests and analyzed with appropriate statistical tests. Results: Significant improvement in cervico-vaginitis was observed in all three groups. At T1, 87.7% patients of Group A, 66.7% of Group B, and 71.5% of Group C achieved infection resolution (all p < 0.05). Positive colposcopy results decreased across all groups (p < 0.001). Positive vaginal swabs and altered vaginal pH decreased in group A and C (p < 0.001). Positive HPV tests decreased in Group B (p < 0.001). Positive Pap tests and clinical examinations decreased significantly across all groups (p < 0.001). The odds ratios were calculated to reveal the significant associations between these diagnostic outcomes. The therapy was well-tolerated, and no major adverse events were reported. Conclusion: Plurigin Ovules exhibited promising therapeutic outcomes in the three cervico-vaginitis conditions studied. Bacterial cervico-vaginitis showed the most significant improvement, followed by fungal and viral cervico-vaginitis. These findings emphasize the potential of Plurigin Ovules as an effective therapeutic option for cervico-vaginal inflammation and infection, highlighting its role in promoting re-epithelialization and reducing inflammatory processes in the cervix and vagina.

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Cervicitis is an inflammatory condition of cervix, when presented along with vaginal discharge; it is termed as cervico-vaginitis. These can be infective, hence important to diagnose due to risk of spreading to upper genital tract. This cross-sectional study was undertaken to evaluate the microbiological spectrum in cervicitis or cervico-vaginitis among 100 sexually active women by Gram stain and Multiplex Real time polymerase chain reaction. Bacterial vaginosis 21(21%) was the most common RTI. Among STIs, genital mycoplasmas were the predominant infections hence further research is required to understand their pathogenesis.

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INTRODUCTION: Cervico-vaginitis is usually the initial infection which, when undiagnosed, can evolve to salpingitis with tubal infertility, ectopic pregnancy, and chronic pelvic pain as consequences. This study aimed at identifying the sociodemographic profile and clinical presentation of women diagnosed with cervico-vaginitis, as well as the microorganisms isolated. MATERIALS AND METHODS: This cross-sectional, descriptive study was carried out between October 1, 2013, and March 31, 2014. Women diagnosed with cervico-vaginitis were recruited. The main variables recorded were maternal age, occupation, marital status, number of sexual partners, clinical presentation, and microorganisms identified. Data were analyzed using SPSS 20.0. RESULTS: The mean maternal age was 25.5 ± 5.6 years. Students were more represented (41.1%), 66% were single, and 69.6% had ≥2 sexual partners. The most frequent symptom was abnormal vaginal discharge (100%). The most frequent microorganisms isolated were genital tract mycoplasmas (67.9%) and Chlamydia trachomatis (55.3%). DISCUSSION: Acute cervico-vaginitis is common among young, single women with multiple sexual partners. Genital tract mycoplasmas were the commonest germs isolated followed by Chlamydia trachomatis. CONCLUSION: Cervico-vaginitis is very common in our setting. Screening for genital tract mycoplasmas should be the first to be requested to women with cervico-vaginitis.