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Background: Chronic obstructive pulmonary disease (COPD) is characterised by persistent and progressive airflow limitations. The study aimed to determine the relationship between eosinophil values in patients with stable and exacerbated COPD, and the relationship of eosinophil values with two drug regimens used as maintenance therapy in stable COPD. Materials and methods: This cross-sectional study and the variables used in this study were eosinophil counts in stable and exacerbated COPD patients. Results: Eighty-three patients with stable and exacerbated COPD were included. Stable COPD (63.9%) was predominant, with the highest degree of symptoms in group A 18 patients (34%) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2; 35 patients (66%). The degree of COPD exacerbation was dominated by Type II COPD 15 patients (50%). Eosinophil counts in patients with stable COPD were less than 100 cells/mm3 37 patients (44.6%), while in patients with COPD exacerbation, it was greater than 100 cells/mm3 with a total of 30 patients (36.1%). Long acting muscarinic antagonist class of drugs was the most used treatment as maintenance therapy in stable COPD 34 patients (64.2%). Conclusion: The eosinophil counts in patients with COPD exacerbation were significantly higher than those in patients with stable COPD. The provision of maintenance therapy in the long acting ß-2 agonist + inhaled glucocorticosteroid group of stable COPD patients was generally provided to COPD patients with eosinophil values greater than 100 cells/mm3, and the provision of long-term maintenance therapy in stable COPD patients was generally given to COPD patients with eosinophil values less than 100 cells/mm3.
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@#Objective To investigate the clinic effectiveness of self-managing on stable chronic obstructive pulmonary disease (COPD).Methods 60 stable COPD patients were divided into the experiment group and control group according to their compliance to the management. The compliant patients (experiment group) received the rehabilitation education. They were assessed with the St. George's respiratory questionnaire (SGRQ) before and a year after treatment. Results After treatment, the scores of activity restriction and the total score of SGRQ in the experiment group improved more than that in the control (P<0.05). Conclusion Self-management is important for improving quality of life in stable COPD.
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@#ObjectiveTo investigate the effect of nutritional status on the parameters of pulmonary function, respiratory muscle strength and drive in patients with chronic obstructive pulmonary disease (COPD).MethodsThe nutritional status of 79 COPD patients at stable period was evaluated regularly, and their pulmonary function and parameters of respiratory muscle strength and drive were examined routinely, and the results were compared with 53 healthy subjects (control group) of the same age and gender.ResultsThe indexes of nutritional status in the COPD patients were all obviously lower than those in the control group (P<0.05～0.01). The parameters of pulmonary function including FEV1, FVC, FEV1%, FVC% and FEV1%/FVC% in the control group were all markedly higher than those in the common nutritional status group and bad nutritional status group, and those were higher in the common nutritional status group than in the bad nutritional status group (P<0.05～0.01). The parameters of respiratory muscle strength including maximal mouth inspiratory pressure (Pmip) and maximal mouth expiratory pressure (PmEp) in the control group were obviously higher than those in the common nutritional status group and bad nutritional status group, but the drive parameter of P0.1 was markedly lower than those in the latter two groups, the Pmip and PmEp in the bad nutritional status group were obviously lower than those in the common nutritional status group, but the P0.1 was obviously higher than that in the common nutritional status group (P<0.05～0.01).ConclusionCOPD patients at stable period are often accompanied by malnutrition, and the nutritional status is decisive to the declined degrees of the parameters of pulmonary function, respiratory muscle strength and drive.