RESUMEN

Two new phthalideisoquinoline hemiacetal alkaloid derivatives, named corybensines A and B (1 and 2), and four known alkaloids (3-6) were isolated from the bulbs of Corydalis decumbens. Their structures were characterized by analysis of 1D/2D NMR and ECD data, quantum chemical ECD calculations, and X-ray diffraction analysis. Among them, compound 2 represents the first naturally occurring phthalideisoquinoline hemiacetal alkaloid derivative with a 2-pyrrolidinone moiety. The activity of the isolated compounds towards neuronal excitability was examined.

Asunto(s)

Alcaloides/química , Corydalis/química , Isoquinolinas/química , Neuronas/efectos de los fármacos , Alcaloides/aislamiento & purificación , Animales , Calcio/metabolismo , Células Cultivadas , China , Isoquinolinas/aislamiento & purificación , Ratones Endogámicos C57BL , Estructura Molecular , Fitoquímicos/química , Fitoquímicos/aislamiento & purificación , Raíces de Plantas/química