RESUMEN

L-MTP-PE (1), an immunomodulator and its metabolite MDP (4) were synthesized from labeled l-alanine and its protected derivative, respectively. The key intermediate product for the labeled L-MTP-PE synthesis, [(13) C3 ,D4 ]-alanyl-cephalin (2A), was synthesized from [(13) C3 ,D4 ]-l-alanine (3A) in three steps. The key intermediate product for labeled MDP synthesis, amine 11, was prepared from [(13) C3 ,(15) N]-Boc-l-alanine (5A) in two steps.

Asunto(s)

Acetilmuramil-Alanil-Isoglutamina/análogos & derivados , Acetilmuramil-Alanil-Isoglutamina/química , Acetilmuramil-Alanil-Isoglutamina/síntesis química , Fosfatidiletanolaminas/química , Fosfatidiletanolaminas/síntesis química , Acetilmuramil-Alanil-Isoglutamina/metabolismo , Técnicas de Química Sintética , Marcaje Isotópico , Fosfatidiletanolaminas/metabolismo