RESUMEN
OBJECTIVES: To evaluate whether induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex after stimulation of the right maxillary canine and to examine whether these metabolic changes and the subjective pain intensity perception correlate. METHODS: Ten male volunteers were included in the pain group and compared with a control group of 10 other healthy volunteers. The pain group received a total of 87-92 electrically induced pain stimuli over 15 min to the right maxillary canine tooth. Contemporaneously, they evaluated the subjective pain intensity of every stimulus using an analogue scale. Neurotransmitter changes within the left insular cortex were evaluated by MR spectroscopy. RESULTS: Significant metabolic changes in glutamine (+55.1%), glutamine/glutamate (+16.4%) and myo-inositol (-9.7%) were documented during pain stimulation. Furthermore, there was a significant negative correlation between the subjective pain intensity perception and the metabolic levels of Glx, Gln, glutamate and N-acetyl aspartate. CONCLUSION: The insular cortex is a metabolically active region in the processing of acute dental pain. Induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex resulting in significant alterations in metabolites. Negative correlation between subjective pain intensity rating and specific metabolites could be observed.
Asunto(s)
Espectroscopía de Resonancia Magnética/métodos , Dolor/patología , Nervio Trigémino/patología , Adulto , Ácido Aspártico/análogos & derivados , Ácido Aspártico/metabolismo , Corteza Cerebral/patología , Electrodos , Femenino , Ácido Glutámico/metabolismo , Glutamina/metabolismo , Humanos , Inositol/metabolismo , Masculino , Persona de Mediana Edad , Modelos Anatómicos , Neurotransmisores/metabolismo , Estudios Prospectivos , Protones , Enfermedades Dentales/patologíaRESUMEN
Magnetic resonance enteroclysis is a promising technique that allows assessment of the small bowel but needs invasive nasoduodenal intubation. We propose a non-invasive distension method for magnetic-resonance imaging (MRI) in which ispaghula, dissolved in an aqueous solution with meglumine gadoterate taken orally over 4 h forms a viscous hydrogel within the intestinal lumen. MRI results from ten volunteers showed good luminal distension, constant signal homogeneity, optimum demarcation of the bowel content from surrounding tissues, and a low rate of artefacts. Our method permits non-invasive high quality MRI of the small bowel.
Asunto(s)
Catárticos/farmacología , Intestino Delgado/efectos de los fármacos , Imagen por Resonancia Magnética/métodos , Psyllium/farmacología , Adulto , Femenino , Humanos , Enfermedades Intestinales/diagnóstico , Masculino , Persona de Mediana EdadRESUMEN
Hypothyroidism is known to affect nearly every organ and organ system of the human body. The goal of the present study was to gain insight into the phosphorus metabolism and bioenergetic function of striated (calf) muscle and liver in patients with hypothyroidism before and after thyroid hormone treatment. With an ISIS (image-selected in vivo spectroscopy) magnetic resonance (MR) technique for volume selection, phosphorus-31 metabolism of the calf muscle in 10 patients and of the liver in seven patients with severe hypothyroidism was studied before and after treatment. In addition, spectra from the calf muscle and liver were obtained in 10 healthy volunteers. Relative to those from the healthy subjects, the P-31 MR spectra from patients with hypothyroidism showed a significantly diminished phosphocreatine/inorganic phosphate ratio (P less than .01). After thyroid hormone substitution therapy, this ratio returned to normal values within several weeks. No statistically significant changes in the spectra of liver tissue could be detected. The results support the theory that hypothyroidism induces a hormone-dependent, fully reversible impairment of the energy metabolism of striated muscle. Changes in liver metabolism observed with biochemical methods are apparently not detectable with state-of-the-art P-31 MR spectroscopy.
Asunto(s)
Hipotiroidismo/metabolismo , Hígado/metabolismo , Músculos/metabolismo , Fósforo/metabolismo , Adulto , Metabolismo Energético/fisiología , Femenino , Humanos , Hipotiroidismo/tratamiento farmacológico , Espectroscopía de Resonancia Magnética , Masculino , Hormonas Tiroideas/fisiología , Hormonas Tiroideas/uso terapéutico , TiroidectomíaRESUMEN
We studied the feasibility of using the surface coil probe technique for the noninvasive in vivo study of ocular tumors by phosphorus 31 magnetic resonance spectroscopy. The characteristic organophosphate metabolites of suspected uveal melanomas before proton beam irradiation were determined qualitatively by phosphorus 31 magnetic resonance spectroscopy in vivo using a three-turn surface coil. Spectra of choroidal hemangioma, osteoma, and metastasis were also obtained in vivo and compared with those of uveal melanomas. Analysis of spectra performed at 1.5 T showed significant peaks of phosphomonoesters, inorganic phosphate, phosphodiesters, phosphocreatine, and adenosine 5'-triphosphates. The unusually high concentration of phosphodiesters may be considered as a marker for uveal melanomas and other choroidal tumors. By analyzing the ratio of phosphocreatine to phosphodiesters spectral area values, we interpreted qualitatively spectra of intraocular tumors to differentiate malignant tumors from benign lesions. Nevertheless, the main limitation of interpreting the spectra was their contamination by signals from surrounding tissues.
Asunto(s)
Neoplasias del Ojo/metabolismo , Imagen por Resonancia Magnética , Melanoma/metabolismo , Neoplasias de la Úvea/metabolismo , Adulto , Anciano , Biomarcadores de Tumor/metabolismo , Ojo/metabolismo , Femenino , Humanos , Masculino , Melanoma/secundario , Persona de Mediana Edad , Compuestos Organofosforados/metabolismo , Isótopos de FósforoRESUMEN
In order to study perfusion effects in MRI under different conditions we developed two different kinds of phantoms. The first phantom exhibits linear capillary flow with several capillaries within one voxel. The second consists of an anion exchange resin with beads forcing the spins to change directions such that they undergo accelerations and decelerations. Both phantoms were imaged with standard spin-echo sequences and signal intensities were quantified at various echo times. Qualitative and quantitative agreements of the data with the results obtained by computations of signal loss due to spin-phase phenomena are excellent, thus suggesting that perfusion effects can be fully understood using these phenomena. It is argued that the phantoms used in conjunction with conventional spin-echo sequences represent a realistic model for studying true capillary networks in conjunction with specialized perfusion sequences.