Asunto(s)
Agranulocitosis/complicaciones , Anfotericina B/uso terapéutico , Cetoconazol/uso terapéutico , Leucemia Linfoide/complicaciones , Leucemia Mieloide Aguda/complicaciones , Micosis/etiología , Neutropenia/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Micosis/tratamiento farmacológicoRESUMEN
Transitional and squamous-cell carcinomas of the bladder that were transplanted and successfully retransplanted in further passages to NMRI nu/nu mice were used to test the efficacy of chemotherapy. Mitomycin and bleomycin consistently retarded tumor growth; results with platinex and methotrexate were variable. Combination therapy was not much better than single-drug therapy. Substances that proved effective in the mouse model produced some response in the corresponding patients in a series of patients on specific chemotherapy. In a previous study we have shown that tumor growth of transplanted human bladder carcinoma accelerates, unlike transplanted renal cell carcinoma when successfully subpassaged, resulting in a uniformly fast growing rate similar in all transplanted tumors including those which initially started with slow growing rates. Most importantly, however, tests in a given tumor conducted on a slow-growing early passage and on a fast-growing late passage produced different results. We concluded that this finding might explain the clinical observation that tumor remission due to chemotherapy in patients with metastatic bladder carcinoma does not last very long and seldom prolongs survival. It is assumed--it is not proved--that substances that proved effective in fast growing passages are probably likely to yield greater prolongation of life than those effective in slow-growing passages.
Asunto(s)
Antineoplásicos/uso terapéutico , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Transicionales/tratamiento farmacológico , Neoplasias de la Vejiga Urinaria/tratamiento farmacológico , Anciano , Animales , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Bleomicina/uso terapéutico , Cisplatino/uso terapéutico , Femenino , Humanos , Masculino , Metotrexato/uso terapéutico , Ratones , Ratones Desnudos , Persona de Mediana Edad , Mitomicinas/uso terapéutico , Trasplante de Neoplasias , Factores de TiempoAsunto(s)
Citarabina/uso terapéutico , Leucemia Mieloide Aguda/tratamiento farmacológico , Trastornos Mieloproliferativos/tratamiento farmacológico , Anciano , Citarabina/administración & dosificación , Relación Dosis-Respuesta a Droga , Femenino , Humanos , Cariotipificación , Leucemia Mieloide Aguda/genética , Masculino , Persona de Mediana Edad , Trastornos Mieloproliferativos/genéticaRESUMEN
A case of M4-AML (acute monoblastic leukemia) is presented which was found to be hypotetraploid (79-80-? chromosomes per metaphase) with direct chromosome preparation while 24- and 48-hour cultures contained predominantly normal and some nonclonal hyperdiploid cells. This observation emphasizes the need for both direct and culture methods to disclose the true karyotype of leukemic cells.