RESUMEN
Thirty two patients with proven chronic bacterial prostatitis were treated with ciprofloxacin 500 mg twice daily orally for four weeks. The causative organisms, cultured from prostatic fluid were Enterobacteriaceae (19 patients), enterococci (9), staphylococci (4), streptococci (3), non-fermentative Gram-negative rods (2) and anaerobic bacteria (9). Nineteen patients had pure cultures, 13 mixed cultures. The susceptibility of all organisms to ciprofloxacin, sulfamethoxazole, trimethoprim and doxycyclin was determined by agar dilution. The effect of therapy was measured by clinical parameters and by repeated cultures of prostatic fluid during and after therapy up to six months. Clinical cure (at one month after therapy) was obtained in 22 patients, improvement in seven; two patients did not respond, one patient had to stop during therapy because of severe nausea. No other side effects were noted. Ciprofloxacin may be a useful alternative drug in the treatment of prostatitis.
Asunto(s)
Infecciones Bacterianas/tratamiento farmacológico , Ciprofloxacina/uso terapéutico , Prostatitis/tratamiento farmacológico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Ensayos Clínicos como Asunto , Infecciones por Enterobacteriaceae/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Five different enzyme activities were estimated in ejaculates obtained from 96 men visiting our infertility clinic. Sperm count showed a significant positive correlation with aspartate-aminotransferase (GOT) and alanine-aminotransferase (GPT). Acid phosphatase was positively correlated with gamma-glutamyl transpeptidase (GGTP) and citrate and negatively with fructose. GGTP showed similar relationships with citrate and fructose. For beta-glucuronidase a low positive correlation with GGTP and GOT was detected. The enzyme activities of 27 ejaculates with a high viscosity were not significantly different from the activities of ejaculates with normal liquefaction. The conclusion is reached that insufficient prostatic enzyme secretion is not the cause of abnormal liquefaction in these patients.
Asunto(s)
Semen/enzimología , Aglutinación Espermática , Fosfatasa Ácida/análisis , Alanina Transaminasa/análisis , Aspartato Aminotransferasas/análisis , Humanos , Masculino , Recuento de Espermatozoides , Motilidad Espermática , gamma-Glutamiltransferasa/análisisRESUMEN
The in-vitro activity of ciprofloxacin against 376 urinary pathogens was determined. The minimal inhibitory concentrations for 90% of the Enterobacteriaceae were 0.03-0.23 mg/l, for Pseudomonas aeruginosa 0.37 mg/l, for Streptococcus faecalis 0.75 mg/l and for Staphylococcus aureus 0.92 mg/l. A 100 mg dose of ciprofloxacin was administered intravenously to 25 patients undergoing prostatectomy. The concentrations in prostate and serum were measured at different intervals. Peak levels in prostate were 3.0 micrograms/g attained 20 min after administration. Peak serum levels were 1.2 mg/l attained 20 min after administration. Serum and prostate elimination was slowly. The overall serum: prostate ratio 1:2.1.
Asunto(s)
Antiinfecciosos Urinarios/metabolismo , Próstata/metabolismo , Prostatitis/tratamiento farmacológico , Quinolinas/metabolismo , Anciano , Antiinfecciosos Urinarios/farmacología , Ciprofloxacina , Enterobacteriaceae/efectos de los fármacos , Enterococcus faecalis/efectos de los fármacos , Humanos , Cinética , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Próstata/microbiología , Prostatectomía/efectos adversos , Prostatitis/etiología , Pseudomonas aeruginosa/efectos de los fármacos , Quinolinas/farmacología , Staphylococcus aureus/efectos de los fármacosRESUMEN
Gamma-glutamyltranspeptidase (GGTP) and beta-glucuronidase activity were measured with commercial kits in 104 ejaculates. The two enzyme activities showed a positive correlation and GGTP activity was significantly correlated with sperm number and citrate concentration. GGTP activity is probably from prostatic origin. Ejaculates with abnormal liquefaction had a lower mean GGTP activity compared with ejaculates which showed normal liquefaction. In contrast beta-glucuronidase activity did not show such a difference.