RESUMEN

The polymorphic and solubility behaviour of the active pharmaceutical ingredient Venlafaxine free base, which is used as an antidepressant, is studied. Using differential scanning calorimetry and slurry experiments, an enantiotropic relation between the three forms was found. Transition temperatures were determined using solubility data and compared with calculated transition temperatures based on the melting enthalpies and temperatures of the different forms. The solubility of Venlafaxine in heptane, toluene and methanol shows a large deviation from ideal behaviour. The deviations are to a large extent determined by the temperature dependence of the difference in fusion enthalpy of the undercooled melt and the solid.

Asunto(s)

Antidepresivos/química , Ciclohexanoles/química , Solventes/química , Termodinámica , Rastreo Diferencial de Calorimetría , Cristalización , Estabilidad de Medicamentos , Estructura Molecular , Transición de Fase , Solubilidad , Temperatura , Temperatura de Transición , Clorhidrato de Venlafaxina , Difracción de Rayos X