RESUMEN
The extent to which the immunofluorescent phenomenon of homogeneous deposition of IgA in the hepatic sinusoids (so-called continuous pattern) was specific for alcoholic hepatic disease was investigated. In 66 of 320 liver biopsy specimens a continuous IgA pattern was observed. Alcoholism was mentioned in the cases of 50 of the 66 patients (76%). The biopsy specimens in the remaining 254 cases continued scanty detectable IgA (discontinuous pattern) or none. In the latter group only eight patients (3%) had histories of alcoholism. A direct correlation between a continuous IgA pattern in the hepatic sinusoids and alcohol abuse is thus inferred (P less than 0.001). Additional findings of the concomitant occurrence of IgA in the perisinusoidal linings of the liver, the wall of superficial cutaneous capillaries, capillaries of the gut, and the glomerular mesangium in association with alcoholic hepatic disease further substantiates the concept of the existence of an IgA-associated disease.
Asunto(s)
Hepatitis Alcohólica/inmunología , Especificidad de Anticuerpos , Técnica del Anticuerpo Fluorescente , Hepatitis Alcohólica/diagnóstico , Humanos , Inmunoglobulina A/análisis , Hígado/inmunología , Hepatopatías Alcohólicas/inmunologíaRESUMEN
A case of solar urticaria is described showing: (I) Action spectra for late erythema (MED), late swelling and wealing with one peak of sensitivity for erythema and wealing at 405 nm. (2) No signs of porphyria. (3) Possibly increased skin mast cells. (4) Short-lived post-irradiation fibrin deposition. (5) Haemolysis. (6) Apparent suppression of urticaria with the antihistamine Incidal.