RESUMEN
Acinetobacter baumannii has often been associated with colonization and/or infection in neonatal intensive care units (NICU). This study describes a clonal spread of carbapenem-resistant A. baumannii (CRAB) isolates in an NICU. In total, 21 CRAB isolates were collected from premature newborns. Only polymyxin B was active against such isolates. Nineteen CRAB isolates were clonally related (Cluster C, which belonged to worldwide-disseminated ST1). All newborns had peripheral access and had received ß-lactam therapy previously. The implementation of strict infection control measures was of fundamental importance to eradicate the clonal type in the study hospital.
Asunto(s)
Infecciones por Acinetobacter/epidemiología , Acinetobacter baumannii/aislamiento & purificación , Carbapenémicos/farmacología , Infección Hospitalaria/epidemiología , Transmisión de Enfermedad Infecciosa , Resistencia betalactámica , Infecciones por Acinetobacter/microbiología , Infecciones por Acinetobacter/prevención & control , Infecciones por Acinetobacter/transmisión , Acinetobacter baumannii/efectos de los fármacos , Estudios de Casos y Controles , Infección Hospitalaria/microbiología , Infección Hospitalaria/prevención & control , Infección Hospitalaria/transmisión , Femenino , Humanos , Recién Nacido , Control de Infecciones/métodos , Unidades de Cuidado Intensivo Neonatal , Masculino , Tipificación MolecularRESUMEN
The anti-inflammatory and antinociceptive effects of the benzylated cubebin derivative, obtained by reaction of (-)-cubebin with benzyl bromide, were investigated using different animal models. The (-)-o-benzyl cubebin showed a low anti-inflammatory effect (16.2%) in relation to cubebin (57%) and indomethacin (77%) in the carrageenin-induced paw edema in rats, but on the other hand it was more effective (80%) than (-)-cubebin (41%) in inhibiting acetic acid-induced writhing in mice, producing dose-response correlation with doses of 10, 20 and 40 mg/kg, respectively. Moreover, this derivative compound did not show activity in both the hot plate and the cell migration test in rats. Overall, the results showed that the benzylation of cubebin were efficient in enhancing only its analgesic activity.
Asunto(s)
Antiinflamatorios no Esteroideos/síntesis química , Antiinflamatorios no Esteroideos/farmacología , Dioxoles/síntesis química , Dioxoles/farmacología , Furanos/síntesis química , Furanos/farmacología , Acetatos , Animales , Carragenina , Edema/inducido químicamente , Edema/prevención & control , Indicadores y Reactivos , Masculino , Dimensión del Dolor/efectos de los fármacos , Piper/química , Ratas , Ratas Wistar , Tiempo de Reacción/efectos de los fármacosRESUMEN
Cubebin, a dibenzylbutyrolactone lignan isolated from the crude hexane extract of the leaves of Zanthoxyllum naranjillo, showed a significant anti-inflammatory activity by using the paw edema induced by carrageenin in rats, but did not provide a significant reduction in the cell migration for the acute carrageenin-induced inflammatory reaction in the peritoneal cavity of rats. Neither was it effective in reducing the edema induced by dextran nor the edema induced by histamine. It partially reduced the edema induced by serotonin. Moreover, it significantly reduced the edema induced by prostaglandin PGE2 and the number of writhings induced by both acetic acid and PGI2 in mice. Therefore, it may be suggested that the mechanism of action of cubebin is similar to that observed for most of the non-steroidal drugs.