RESUMEN
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.
Asunto(s)
Metilación de ADN/genética , Epigénesis Genética/genética , Código de Histonas/genética , Hipertensión Pulmonar/genética , Hipertensión Pulmonar/fisiopatología , ARN no Traducido/genética , Regulación hacia Abajo/genética , Humanos , Hipertensión Pulmonar/terapia , Terapia Molecular Dirigida , Arteria Pulmonar/patología , Ubiquitinación/genética , Regulación hacia Arriba/genéticaRESUMEN
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.
Asunto(s)
Humanos , Metilación de ADN/genética , ARN no Traducido/genética , Epigénesis Genética/genética , Código de Histonas/genética , Hipertensión Pulmonar/fisiopatología , Hipertensión Pulmonar/genética , Arteria Pulmonar/patología , Regulación hacia Abajo/genética , Regulación hacia Arriba/genética , Ubiquitinación/genética , Terapia Molecular Dirigida , Hipertensión Pulmonar/terapiaRESUMEN
This article describes the case of a 67-year-old woman who presented with a typical left hemifacial spasm of 8-month duration. After 2 months, she experienced lacinating and sharp shock-like pain in the left side of her face affecting the V1 and V2 territories and a discrete attenuation of nauseous reflex on the left side. CT angiography and MRI revealed significant compression of left cranial nerves V, VII, VIII, IX and X by a giant and tortuous vertebro-basilar arterial complex. This case illustrates the nonlinearity of the relationship between the presence of the stressor factor and the actual manifestation of the disease.