RESUMEN
As neoplasias ósseas malignas se apresentam sob diversas formas e, na maioria dos casos, por serem assintomáticas e de crescimento rápido, são detectadas já em estágios avançados, o que aumenta o porte da cirurgia e piora o prognóstico do paciente. Este trabalho tem por objetivo apresentar os diversos recursos imaginológicos que podem ser utilizados para o diagnóstico precoce e estadiamento das neoplasias malignas do complexo bucal e maxilofacial, bem como as limitações e indicações de cada exame, sempre procurando estabelecer um protocolo eficaz e acessível para o paciente, além de tornar a cirurgia mais conservadora e adequada a cada caso
Asunto(s)
Humanos , Neoplasias Óseas , Diagnóstico por Imagen , Neoplasias Óseas/etiología , Neoplasias Óseas/patología , Tomografía Computarizada por Rayos X , Espectroscopía de Resonancia MagnéticaRESUMEN
Hsp32 is a heat shock gene in D. discoideum. We have previously observed that heat stress-induced change produces a broad band on Northern blots, suggesting that more than one population of mRNA is present under those conditions. This was not the result of a defect in the splicing of the hsp32 mRNA, nor did it result from the use of a different transcription start site under heat shock conditions. Here, we show that the broad banding pattern reflects the appearance of a transcript with a poly(A) tail that is approximately 100 nt longer than that seen in unstressed cells. Experiments indicated that this tail was not a property of newly synthesized mRNA but rather a response to heat stress. This response appeared to be specific to the hsp32 transcript and did not result in the retention of the RNA in the nucleus. These results document a relatively unusual heat shock response and also indicate that the nature of the response differs among RNAs and has selective consequences.
Asunto(s)
Dictyostelium/genética , Proteínas de Choque Térmico/genética , Respuesta al Choque Térmico/genética , Poli A/metabolismo , Proteínas Protozoarias , ARN/metabolismo , Animales , Medios de Cultivo/farmacología , Dictyostelium/química , Dictyostelium/metabolismo , Células Eucariotas/citología , Células Eucariotas/efectos de los fármacos , Células Eucariotas/metabolismo , Expresión Génica/efectos de los fármacos , Expresión Génica/genética , Regulación de la Expresión Génica/efectos de los fármacos , Proteínas de Choque Térmico/efectos de los fármacos , Poli A/genética , ARN/efectos de los fármacos , ARN/genética , ARN Mensajero/efectos de los fármacos , ARN Mensajero/genética , ARN Mensajero/metabolismo , Temperatura , Factores de TiempoRESUMEN
We have cloned, from Dictyostelium discoideum, a cDNA encoding a new heat-shock (HS) protein (Hsp) with a predicted molecular mass of 31,447 Da. Outside of its low molecular mass, this Hsp does not share any similarity with the small Hsp currently identified or with alpha-crystallins. Northern blot analysis indicates that this HS-inducible gene is also developmentally regulated
.