RESUMEN
OBJECTIVE: The aim of this work was to investigate cardiovascular risk factors and oxidative stress parameters as well as sleep disturbances in polysomnography recordings of 38 postmenopausal women with insomnia. METHODS: Polysomnography recordings were performed on subjects for sleep analysis. Oxidative stress parameters were analyzed by measuring blood concentration of catalase, superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS) and glutathione. For cardiovascular risk factors, we measured plasma levels of homocysteine, folic acid and vitamin B6. RESULTS: Findings of polysomnography recordings revealed: 68% experienced decreased sleep efficiency, 50% had apnea, 7.8% had periodic leg movements and 2.6% had bruxism (involuntary gnashing and grinding of the teeth during sleep). Our results showed that the majority of our subjects presented normal concentrations of the parameters studied according to standards reached in our laboratory. The only notable exception was TBARS. In this case, only 21% displayed normal values. We also found inverse correlations between SOD activity and both age and time of menopause. CONCLUSIONS: Although all women complained of insomnia, 50% of them demonstrated apnea during polysomnography recordings. Of the parameters measuring oxidative stress, only TBARS levels were increased in our sample. Some clinical data, such as time of onset of menopause, may be associated with the oxidative stress status of these women, probably due to the lack of estrogen and to sleep disturbances, such as apnea.
Asunto(s)
Enfermedades Cardiovasculares , Estrés Oxidativo/fisiología , Posmenopausia , Trastornos del Inicio y del Mantenimiento del Sueño/epidemiología , Trastornos del Sueño-Vigilia/epidemiología , Enfermedades Cardiovasculares/sangre , Catalasa/sangre , Femenino , Ácido Fólico/sangre , Homocisteína/sangre , Humanos , Persona de Mediana Edad , Polisomnografía , Factores de Riesgo , Trastornos del Inicio y del Mantenimiento del Sueño/complicaciones , Trastornos del Sueño-Vigilia/complicaciones , Superóxido Dismutasa/sangre , Sustancias Reactivas al Ácido Tiobarbitúrico/análisis , Vitamina B 6/sangreRESUMEN
The antibody response obtained after one booster dose of rabies vaccine prepared in suckling mice brains at Serviço de Saúde Pública da Cidade do Rio de Janeiro is described. Four prime vaccinal groups were used: group I, persons who had received 16 doses 10 years before this investigation; group II, persons who had received 5 doses of the vaccine 10 years before; group III, persons who had received 9 doses 5 years before; and group IV, persons who had received 16 doses 5 years before. One booster dose of the vaccine was administered to all persons involved in the study. Blood samples were collected before vaccination (day 0), then 7 and 30 days after vaccination. Antibody titres were determined by seroneutralization test in mice (SWM). The results demonstrated that all persons who had been treated with 5, 9 or 16 doses of the vaccine 5 to 10 years before had their antibody titres increased on the 7th and 30th days after one booster dose.
Asunto(s)
Vacunas Antirrábicas/administración & dosificación , Animales , Anticuerpos Antivirales/sangre , Brasil , Relación Dosis-Respuesta Inmunológica , Humanos , Esquemas de Inmunización , Inmunización Secundaria , Ratones , Vacunas Antirrábicas/efectos adversos , Vacunas Antirrábicas/aislamiento & purificación , Seguridad , Factores de TiempoRESUMEN
Survey data from 300 randomly selected private dental practitioners working in Belo Horizonte, Minas Gerais, were used to evaluate the infection control procedures routinely practiced here. The function of this report might be to alert the teaching team from Dental Schools and the dentists to the problems that potentially contribute to the transmission of infectious disease as a first step for additional specific recommendations to an effective and safe infection controL program that we intend to discuss later.