RESUMEN

BACKGROUND: The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population. METHODS: Association analyses between DR15 and the clinical and demographic variables were made. RESULTS: We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P < .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018).

Asunto(s)

Predisposición Genética a la Enfermedad/epidemiología , Predisposición Genética a la Enfermedad/genética , Subtipos Serológicos HLA-DR/genética , Esclerosis Múltiple/epidemiología , Esclerosis Múltiple/genética , Adulto , Brasil/epidemiología , Estudios Transversales , Femenino , Subtipos Serológicos HLA-DR/sangre , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/sangre