RESUMEN

Objective: To investigate whether Euterpe oleracea Mart. (açaí) seed extract (ASE) prevents maternal cardiovascular changes and intrauterine growth restriction (IUGR) in experimental preeclampsia (PE).Methods: ASE administration (200 mg/kg/day) during mid to late pregnancy in a rat model of L-NAME-induced PE.Results: ASE impaired the maternal hypertension and microalbuminuria as well as the lower fetal and placental weight in experimental PE. ASE also prevented the maternal vascular dysfunction and lipoperoxidation in this model.Conclusion: ASE protected against maternal cardiovascular changes and IUGR in the L-NAME-induced PE. The protective effect of ASE may be partly explained by its antioxidant property.

Asunto(s)

Antioxidantes/uso terapéutico , Euterpe , Retardo del Crecimiento Fetal/prevención & control , Hipertensión Inducida en el Embarazo/prevención & control , Extractos Vegetales/uso terapéutico , Preeclampsia/fisiopatología , Animales , Antioxidantes/farmacología , Femenino , Retardo del Crecimiento Fetal/fisiopatología , Hipertensión Inducida en el Embarazo/fisiopatología , Estrés Oxidativo/efectos de los fármacos , Extractos Vegetales/farmacología , Embarazo , Ratas , Ratas Wistar