RESUMEN
Serial blood measurements of myoglobin (MG) revealed a common trend of change in acute macro- and microfocal myocardial infarction, focal myocardial dystrophy, angina of effort and angina at rest as well as unstable angina. Differences in myoglobinemic parameters (MG peak level, increment rate, normalization time) between different clinical variants of CHD are quantitative. It is suggested that there is an intravital relationship between each of the examined clinical variants, in their acute phase, and a specific equivalent of an acute myocardial ischemic damage focus, as shown by the degree of hypermyoglobinemia.
Asunto(s)
Enfermedad Coronaria/sangre , Mioglobina/sangre , Creatina Quinasa/sangre , Femenino , Humanos , Isoenzimas , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
Good correlation between the size of necrosis, as measured by precordial cartograms of 35 ECG leads, and blood CPK and LDH activity and myoglobin levels was demonstrated in 21 myocardial infarction patients. Myoglobin measurement is particularly informative for early diagnosis of myocardial infarction and the assessment of the size of necrosis. A formula is proposed for the estimation of the size of necrosis on the basis of variation in R waves from 35 ECG leads.
Asunto(s)
Creatina Quinasa/sangre , L-Lactato Deshidrogenasa/sangre , Infarto del Miocardio/diagnóstico , Miocardio/patología , Mioglobina/sangre , Anciano , Pruebas Enzimáticas Clínicas , Electrocardiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/sangre , Infarto del Miocardio/patología , NecrosisRESUMEN
Comparatively moderate blood fermentemia (KPK, AST, KPK-MB and LDH1) exceeding the level of the statistic M + 1S index in the control group and lasting over 3 to 7 days can be viewed as one of the diagnostic criteria of the preinfarction state. The lack of the correlation between the enzymatic characteristics and the data on blood myoglobin concentration and precordial cartography readings (ECG 35 leads) makes the use of the latter two methods more preferable in the evaluation of the area of necrosis in patients with repeated myocardial infarctions and requires a more careful approach to the prognosis of complications in this patients' group.