RESUMEN
A series of biochemical and immunological investigations was performed in a group of 33 silicosis patients and in 34 controls. The results obtained suggest future prospects of utilizing the following tests as silicotic-fibrosis markers: alpha 2-globulin and ceruloplasmin levels, activity of certain lysosomal enzymes (beta-galactosidase and beta-acetylglucosaminidase), IgM and IgG immunoglobulins, elastases, and the C4 component of the complement.
Asunto(s)
Silicosis/diagnóstico , Acetilglucosaminidasa/sangre , Adulto , alfa-Globulinas/análisis , Ceruloplasmina/análisis , Complemento C3/análisis , Complemento C4/análisis , Creatinina/sangre , Humanos , Hidroxiprolina/orina , Inmunoglobulinas/análisis , Masculino , Persona de Mediana Edad , Elastasa Pancreática/sangre , Silicosis/inmunología , Silicosis/metabolismo , beta-Galactosidasa/sangreAsunto(s)
Agranulocitosis/inducido químicamente , Contaminantes Ocupacionales del Aire/efectos adversos , Derivados del Benceno/efectos adversos , Benceno/efectos adversos , Industria Química , Adulto , Femenino , Humanos , Recuento de Leucocitos/efectos de los fármacos , Masculino , Persona de Mediana Edad , PoloniaAsunto(s)
Contaminantes Ocupacionales del Aire/efectos adversos , Benceno/efectos adversos , Industria Química , Adulto , Derivados del Benceno/efectos adversos , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Femenino , Cefalea/inducido químicamente , Humanos , Masculino , Persona de Mediana Edad , Hipersensibilidad Respiratoria/inducido químicamenteRESUMEN
In the group of 349 women exposed to organic solvents, chiefly extraction naphtha, n-hexane and toluene, medical examinations were carried out. Among them the 100 persons without signs of chronic intoxication were selected. In this group the following examinations were performed: Graham-Kendall's and Bender's psychologic tests, electroencephalograms, testing motor conduction of peripheral nerves. In the exposed and control groups urinary phenol and hippuric acid content was determined. Air solvents concentration at work environment was also measured. Within the examined group, psychologic tests score was as follows: 37 persons without organic changes, 28 on the border-1 and of the norm, 35 with cortical organic changes. No significant difference in average urinary phenol and hippuric acid content was found in 3 groups mentioned above. The hippuric acid excretion in the exposed group was significantly higher than in the control one. Hippuric acid in workers with normal and abnormal electrocardiograms was at the same level. No difference in the hippuric acid concentration in groups with normal and slowed nerve conduction velocity was noticed. The urinary phenol content in the exposed and control groups was at the same level. At some work posts extraction naphtha and toluene concentration exceeded MAC. Cortical organic changes and subclinical neuropathy were significantly more frequent in workers exposed to high concentrations of extraction naphtha and toluene. The authors suppose that subclinical signs, detectable by means of psychologic and neurophysiologic methods, may be considered as early symptoms of individual reaction to organic solvents.
Asunto(s)
Adhesivos/toxicidad , Contaminantes Ocupacionales del Aire/toxicidad , Zapatos , Solventes/toxicidad , Adulto , Femenino , Hipuratos/orina , Humanos , Nervio Mediano/efectos de los fármacos , Memoria a Corto Plazo/efectos de los fármacos , Persona de Mediana Edad , Conducción Nerviosa/efectos de los fármacos , Nervio Peroneo/efectos de los fármacos , Fenoles/orina , Nervio Tibial/efectos de los fármacos , Nervio Cubital/efectos de los fármacosRESUMEN
This paper was aimed at an evaluation of two different methods of carboxyhemoglobin determination in blood: colorimetric method according to Wolff and conductometric method. In result of this comparison it has been established that Wolff's method was less accurate and gave higher results than did the conductometric method. Reliability of both methods was evaluated and the reasons for Wolff's method errors were discussed.