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Owing to the influence of human activities, the issue of heavy metal pollution in farmland soil at the urban-rural fringe has become increasingly prominent. An accurate understanding of the characteristics of soil-crop heavy metal pollution in these areas is of great significance for ensuring food safety and promoting social sustainable development. Most of the existing studies rely on small-scale field monitoring, but research at the national level has not effectively captured the unique pollution dynamics of this urban-rural interface. Based on the published literature, the present study investigated the status of heavy metal pollution in the soil-crop system within China's urban-rural fringe through Meta-analysis. On this basis, the study evaluated the risks to human health associated with heavy metals in major crops in a given region. The results showed that heavy metals were accumulated in farmland soil in the urban-rural fringe of China, especially in Cd ï¼Igeo = 0.89ï¼ pollution, and its distinct spatial heterogeneity patterns emerged. When considering different types of cultivated land, paddy fields and irrigated land exhibited a higher tendency of heavy metal accumulation. From the varying urbanization levels, the accumulation of heavy metals in soils of small and medium-sized cities was more obvious. For crops in the urban-rural fringe, Cd and Pb had the highest exceedance rate in rice ï¼28.25% and 39.64%ï¼ and wheat ï¼27.72% and 42.72%ï¼. The health risk assessment results of heavy metals in crops showed that Cd was the main element that posed human health risks, which had some degree of non-carcinogenic risk and unacceptable carcinogenic risk to both children and adults.
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Ciudades , Productos Agrícolas , Monitoreo del Ambiente , Metales Pesados , Contaminantes del Suelo , Contaminantes del Suelo/análisis , China , Metales Pesados/análisis , Productos Agrícolas/crecimiento & desarrollo , Suelo/química , AgriculturaRESUMEN
Platensilin, platensimycin, and platencin are potent inhibitors of ß-ketoacyl-acyl carrier protein synthase (FabF) in the bacterial and mammalian fatty acid synthesis system, presenting promising drug leads for both antibacterial and antidiabetic therapies. Herein, a bioinspired skeleton reconstruction approach is reported, which enables the unified synthesis of these three natural FabF inhibitors and their skeletally diverse analogs, all stemming from a common ent-pimarane core. The synthesis features a diastereoselective biocatalytic reduction and an intermolecular Diels-Alder reaction to prepare the common ent-pimarane core. From this intermediate, stereoselective Mn-catalyzed hydrogen atom-transfer hydrogenation and subsequent Cu-catalyzed carbenoid C-H insertion afford platensilin. Furthermore, the intramolecular Diels-Alder reaction succeeded by regioselective ring opening of the newly formed cyclopropane enables the construction of the bicyclo[3.2.1]-octane and bicyclo[2.2.2]-octane ring systems of platensimycin and platencin, respectively. This skeletal reconstruction approach of the ent-pimarane core facilitates the preparation of analogs bearing different polycyclic scaffolds. Among these analogs, the previously unexplored cyclopropyl analog 47 exhibits improved antibacterial activity (MIC80 = 0.0625 µg/mL) against S. aureus compared to platensimycin.
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Adamantano , Aminobenzoatos , Aminofenoles , Anilidas , Compuestos Policíclicos , Aminofenoles/química , Aminofenoles/farmacología , Aminofenoles/síntesis química , Compuestos Policíclicos/química , Compuestos Policíclicos/farmacología , Compuestos Policíclicos/síntesis química , Adamantano/química , Adamantano/farmacología , Adamantano/síntesis química , Adamantano/análogos & derivados , Anilidas/farmacología , Anilidas/química , Anilidas/síntesis química , Aminobenzoatos/farmacología , Aminobenzoatos/química , Aminobenzoatos/síntesis química , Antibacterianos/farmacología , Antibacterianos/síntesis química , Antibacterianos/química , Staphylococcus aureus/efectos de los fármacos , Estructura Molecular , Reacción de Cicloadición , Pruebas de Sensibilidad Microbiana , Estereoisomerismo , Inhibidores Enzimáticos/farmacología , Inhibidores Enzimáticos/síntesis química , Inhibidores Enzimáticos/químicaRESUMEN
Metal halide perovskites (MHPs) have emerged as attractive candidates for producing green hydrogen via photocatalytic pathway. However, the presence of abundant defects and absence of efficient hydrogen evolution reaction (HER) active sites on MHPs seriously limit the solar-to-chemical (STC) conversion efficiency. Herein, to address this issue, we present a bi-functionalization strategy through decorating MHPs with a molecular molybdenum-sulfur-containing co-catalyst precursor. By virtue of the strong chemical interaction between lead and sulfur and the good dispersion of the molecular co-catalyst precursor in the deposition solution, a uniform and intimate decoration of the MHPs surface with lead sulfide (PbS) and amorphous molybdenum sulfide (MoSx) co-catalysts is obtained simultaneously. We show that the PbS co-catalyst can effectively passivate the Pb-related defects on the MHPs surface, thus retarding the charge recombination and promoting the charge transfer efficiency significantly. The amorphous MoSx co-catalyst further promotes the extraction of photogenerated electrons from MHPs and facilitates the HER catalysis. Consequently, drastically enhanced photocatalytic HER activities are obtained on representative MHPs through the synergistic functionalization of PbS and MoSx co-catalysts. A solar-to-chemical (STC) conversion efficiency of ca. 4.63% is achieved on the bi-functionalized FAPbBr3-xIx, which is among the highest values reported for MHPs.
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In this study, a Meta-analysis was used to investigate the pollution status of eight farmland soil heavy metal elements (As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) in China. Meanwhile, their spatiotemporal changes and differences between different types of cultivated land were explored. The research data were chosen from 449 relevant literature data collected by CNKI and Web of Science from 2005 to 2021, and the Meta-analysis used a weighted method based on "sampling numbers", "study area", and "standard deviation". The results showed that the national average values of the eight heavy metal elements in Chinese farmland soil were ω(As)11.00 mg·kg-1, ω(Cd)0.350 2 mg·kg-1, ω(Cr)62.91 mg·kg-1, ω(Cu)28.87 mg·kg-1, ω(Hg)0.135 1 mg·kg-1, ω(Ni)28.91 mg·kg-1, ω(Pb)34.67 mg·kg-1,and ω(Zn)90.24 mg·kg-1. Compared with their background values, all elements except As accumulated to some extent, and Cd and Hg accumulated the most, exceeding their background values by 177.9% and 340.3%, respectively. The research results indicated that Cd and Hg were the main pollution elements in farmland soil in China, and their accumulation was mainly influenced by human activities. In terms of their temporal and spatial changes, the Yunnan-Guizhou Plateau and the eastern coast were the most concentrated areas of pollution cases, and the pollution center shifted from the middle reaches of the Yangtze River to the southwest over time. The accumulation of heavy metals in farmland soil was affected by crop planting types, and the accumulation of heavy metals in vegetable and paddy soil was significantly greater than that in other cultivated land types.
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Mercurio , Metales Pesados , Contaminantes del Suelo , Humanos , Suelo , Granjas , China , Cadmio , Plomo , Monitoreo del Ambiente/métodos , Medición de Riesgo , Contaminantes del Suelo/análisis , Metales Pesados/análisisRESUMEN
Metal-organic frameworks (MOFs) have emerged as promising platforms for photocatalytic hydrogen evolution reaction (HER) due to their fascinating physiochemical properties. Rationally engineering the compositions and structures of MOFs can provide abundant opportunities for their optimization. In recent years, high-entropy materials (HEMs) have demonstrated great potential in the energy and environment fields. However, there is still no report on the development of high-entropy MOFs (HE-MOFs) for photocatalytic HER in aqueous solution. Herein, the authors report the synthesis of a novel p-type HE-MOFs single crystal (HE-MOF-SC) and the corresponding HE-MOFs nanosheets (HE-MOF-NS) capable of realizing visible-light-driven photocatalytic HER. Both HE-MOF-SC and HE-MOF-NS exhibit higher photocatalytic HER activity than all the single-metal MOFs, which are supposed to be ascribed to the interplay between the different metal nodes in the HE-MOFs that enables more efficient charge transfer. Moreover, impressively, the HE-MOF-NS demonstrates much higher photocatalytic activity than the HE-MOF-SC due to its thin thickness and enhanced surface area. At optimum conditions, the rate of H2 evolution on the HE-MOF-NS is ≈13.24 mmol h-1 g-1, which is among the highest values reported for water-stable MOF photocatalysts. This work highlights the importance of developing advanced high-entropy materials toward enhanced photocatalysis.
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The 5-year survival rate for patients with lung cancer, the world's second most frequent malignant tumor, is less than 20%, and its prognosis cannot be clearly predicted. Our aim was to analyze the epidermal growth factor receptor (EGFR) rs763317 (G>A) single nucleotide polymorphism and its association with prognosis in Chinese Han lung cancer patients. 839 patients with primary lung cancer were recruited, and genomic DNA was extracted and genotyped by SNPscan. Kaplan-Meier technique and multivariate Cox proportional hazards model were used to analyze the association between prognosis and EGFR polymorphism rs763317. A significant association after stratification by age, significantly increased lung cancer risk was associated with the AA homozygous genotype of rs763317 (adjusted hazard ratio = 2.53, 95% CI: 1.31-4.88, p=0.005), and conferred a poor survival for lung cancer patients (MST: median survival time: 13.6 months) compared with GG genotype (MST: 41.5 months), and in the recessive model AA genotype (AA vs. GG + GA; adjusted hazard ratio = 2.57, 95% CI: 1.34-4.93, p=0.004) who were young (<60 years) had a significantly increased risk of death. The EGFR polymorphism rs763617 might serve as a significant genetic marker for predicting the prognosis of lung cancer.
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Carcinoma de Pulmón de Células no Pequeñas , Neoplasias Pulmonares , Humanos , Carcinoma de Pulmón de Células no Pequeñas/genética , Pueblos del Este de Asia , Receptores ErbB/genética , Predisposición Genética a la Enfermedad , Genotipo , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patología , Polimorfismo de Nucleótido Simple , PronósticoRESUMEN
Ruthenium (Ru) has been considered a promising electrocatalyst for electrochemical hydrogen evolution reaction (HER) while its performance is limited due to the problems of particle aggregation and competitive adsorption of the reaction intermediates. Herein, we reported the synthesis of a zinc (Zn) modified Ru nanocluster electrocatalyst anchored on multiwalled carbon nanotubes (Ru-Zn/MWCNTs). The Ru-Zn catalysts were found to be highly dispersed on the MWCNTs substrate. Moreover, the Ru-Zn/MWCNTs exhibited low overpotentials of 26 and 119 mV for achieving current intensities of 10 and 100 mA cm-2 under alkaline conditions, respectively, surpassing Ru/MWCNTs with the same Ru loading and the commercial 5 wt% Pt/C (47 and 270 mV). Moreover, the Ru-Zn/MWCNTs showed greatly enhanced stability compared to Ru/MWCNTs with no significant decay after 10,000 cycles of CV sweeps and long-term operation for 90 h. The incorporation of Zn species was found to modify the electronic structure of the Ru active species and thus modulate the adsorption energy of the Had and OHad intermediates, which could be the main reason for the enhanced HER performance. This study provides a strategy to develop efficient and stable electrocatalysts towards the clean energy conversion field.
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The practical deployment of promising NiFe-based oxygen evolution reaction (OER) electrocatalysts is heavily limited due to the constrain in both stability and activity under industrial conditions. Herein, a 3D free-standing NiFe(oxy)hydroxide-based electrode with Schottky junction is constructed, in which NiFe(oxy)hydroxide (NiFe(OH)x ) nanosheets are chemically assembled on the top of metal-like Ni3 S2 scaffold that are in situ formed on commercial Ni mesh. Such an assembly enhances the binding strength of each components, promotes the charge transfer across the interfaces, and modulates the electronic and nanostructural features of NiFe(OH)x . Consequently, the electrode delivers current densities of as high as 500 and 1000 mA cm-2 for OER at overpotentials of only 248 and 270 mV with long-term stability in 1 m KOH. When it was paired with a NiMo hydrogen evolution cathode in a practical two-electrode system, a current density of 1000 mA cm-2 is achieved at a low cell voltage of ≈1.61 V at 80 °C in 30% KOH without losing performance for at least 1500 h. This is the best performance reported thus far for alkaline water electrolysis under industrial conditions, demonstrating its great potential for practical applications.
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Defects are ubiquitous in semiconductors and critical to photo(electro)chemical performance, but the change of defect properties under light irradiation remains poorly understood. Herein, we studied defect change properties of Ta3N5 with transient absorption (TA) spectroscopy. A broad transient absorption (>650 nm) was observed and attributed to trapped electrons in oxygen impurities (substitution oxygen at nitrogen sites, ON), and two bleach signals at 510 and 580 nm were obtained and ascribed to free holes of Ta3N5. The charge recombination between the trapped electrons and the free holes is sensitively related to ON defects. The trap-detrapping recombination is retarded by increase of excitation intensity, which is contrary to the normal dependence of charge dynamics on excitation intensity. This abnormal dependence indicates that shallow ON⢠(singly positive charge states) defects of Ta3N5 transform to deeper ON× (neutral charge states) defects under strong light irradiation. The defect transformation results in long-lived free holes in Ta3N5 for photo(electro)catalysis.
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BACKGROUND: Persisting shoulder stiffness adversely affects quality of life by causing pain and motion restrictions especially in patients with diabetes. OBJECTIVE: The aim of this study was to evaluate the outcomes of arthroscopic capsular release in patients with idiopathic shoulder stiffness. METHOD: A literature search was conducted in electronic databases and studies were selected by following precise eligibility criteria. Random-effects meta-analyses were performed to estimate the changes at latest follow-up in scores of the Constant, American Shoulder and Elbow Surgeons (ASES), and University of California at Los Angelis (UCLA) scales, Visual Analogue Scale (VAS), and shoulder range of motion. RESULTS: Nineteen studies were included. The follow-up duration was 42 months [95% confidence interval (CI): 32, 51]. Improvements in scores of the Constant, ASES, UCLA scales, and VAS were 48.3 [95% CI: 38.0, 58.6], 44.6 [95% CI: 24.6, 64.6], 19.3 [95% CI: 16.6, 22.0], and -6.1 [95% CI: -6.9, -5.4] respectively (P< 0.05 all). Improvements in the shoulder range of motion were: abduction 82.0 [95% CI: 65.0, 98.9]; forward flexion 75.9 [95% CI: 59.7, 92.1]; external rotation 43.2 [95% CI: 37.5, 49.0]; and internal rotation 25.4 [95% CI: 15.2, 35.5] degrees; P< 0.05 all). CONCLUSION: Arthroscopic capsular release effectively improves shoulder function in patients with idiopathic shoulder stiffness.
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Liberación de la Cápsula Articular , Artropatías/cirugía , Articulación del Hombro/cirugía , Artroscopía , Humanos , Dimensión del Dolor , Rango del Movimiento Articular , Rotación , Hombro , Resultado del Tratamiento , Escala Visual AnalógicaRESUMEN
Three-dimensional (3D) organic-inorganic hybrid perovskites have demonstrated excellent capability in solar fuel production, while the two-dimensional (2D) counterparts are generally considered inferior candidates due to the high exciton binding energy and weak light absorption. Herein, contrary to our common understanding, we find that 2D perovskites can perform photocatalytic H2 production from HI splitting more efficiently than their 3D counterparts. We observed sharp difference between 2D perovskites crystals with organic phenylalkylammonium cations of different lengths and the 3D counterparts in their stabilization behavior in aqueous solution. Moreover, we show that the organic cations length of the 2D perovskites affects the nanostructures, optoelectronic properties, and the charge transfer process significantly, which determines the photocatalytic activity of the 2D perovskites. Among the 2D perovskites under investigation, phenylmethylammonium lead iodide with the shortest organic cations achieved the best solar-to-chemical conversion efficiency of ca. 1.57 %, which is the highest value ever reported for hybrid perovskites.
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The objective of this study was to predict the value of lymphocyte subsets in cancer progression. Peripheral blood was obtained from 327 untreated patients with cancer and 158 healthy volunteers. Levels of lymphocyte subsets were determined by flow cytometry. There were decreased levels of natural killer (NK) cells, CD8+ T cells, and naïve CD4+ /CD4+ T cells in untreated patients with cancer compared to those in healthy controls. Inversely, there were elevated levels of the following T-cell percentages in cancer patients compared to those in healthy controls: memory CD4+ /CD4+ , CD8+ T cells, HLA-DR/CD8+ , CD8+ CD38+ /CD8+ , and CD4+ /CD8+ . In addition, there are a decreasing trend in terms of CD4+ T-cell counts and an increase CD8+ HLA-DR/CD8+ T-cell and CD8+ CD38+ /CD8+ T-cell percentages in the advanced stage. An increasing trend with advanced tumor stage and the percentages of CD8+ HLA-DR/CD8+ T cells and CD8+ CD38+ /CD8+ T cells was shown in this study. There are a negative correlation for CD4+ T-cell counts and positive correlation for percentages of CD8+ HLA-DR/CD8+ T cell and CD8+ CD38+ /CD8+ T cells with the lymph node metastasis. In the presence of distant metastatic spread, we observed higher NK-cell counts, CD8+ HLA-DR/CD8+ T-cell percentages, CD8+ CD38+ /CD8+ T-cell percentages, as well as lower CD4+ T-cell counts than those in the absence of distant metastases spread. Abnormal levels of NK cell, CD8+ T cells, memory CD4+ /CD4+ , naïve CD4+ / CD4+ , CD8+ HLA-DR/CD8+ , CD8+ CD38+ /CD8+ , and CD4+ /CD8+ can be a potential blood biomarkers of cancer development. CD4+ T-cell counts and percentages of CD8+ HLA-DR/ CD8+ and CD8+ CD38+ / CD8+ can predict the cancer progression.
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Biomarcadores de Tumor/metabolismo , Recuento de Linfocitos/métodos , Linfocitos/metabolismo , Neoplasias/sangre , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Microambiente Tumoral , Adulto JovenRESUMEN
Photo-thermo catalysis, which integrates photocatalysis on semiconductors with thermocatalysis on supported nonplasmonic metals, has emerged as an attractive approach to improve catalytic performance. However, an understanding of the mechanisms in operation is missing from both the thermo- and photocatalytic perspectives. Deep insights into photo-thermo catalysis are achieved via the catalytic oxidation of propane (C3 H8 ) over a Pt/TiO2 -WO3 catalyst that severely suffers from oxygen poisoning at high O2 /C3 H8 ratios. After introducing UV/Vis light, the reaction temperature required to achieve 70 % conversion of C3 H8 lowers to a record-breaking 90 °C from 324 °C and the apparent activation energy drops from 130â kJ mol-1 to 11â kJ mol-1 . Furthermore, the reaction order of O2 is -1.4 in dark but reverses to 0.1 under light, thereby suppressing oxygen poisoning of the Pt catalyst. An underlying mechanism is proposed based on direct evidence of the in-situ-captured reaction intermediates.
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Nitrogen (N), phosphorus (P), and potassium (K) exert various effects on adzuki bean yields. Our research was conducted in a semi-arid area, and four test sites were established in environments that have chernozem or sandy loam soils. During a five-year period, the effects of N, P, and K fertilizers on yield were comprehensively investigated in field trials (2014-2016) and for model-implementation trials (2017-2018), with models established prior to the latter. In the field trials, 23 treatments comprising different N, P, and K combinations significantly affected both yield and yield components, and regression analysis indicated that the experimental results were suitable for model establishment. The model subsequently demonstrated that the yield and the yield components were more sensitive to N and K fertilizer than to P fertilizer. Moreover, the yield and yield components increased. These yield increases were intense in response to the 0.5 to 1.34 levels in terms of the single effects; interaction effects; and the effects of combinations of N, P, and K fertilizers. Moreover, the effects of combinations of N, P, and K fertilizers were more significant on yield than were the single or interaction effects of N, P, and K fertilizers. The optimal fertilizer combination that resulted in high yields (≥1941.53 kg ha-1) comprised 57.23-68.43 kg ha-1 N, 36.04-47.32 kg ha-1 P2O5 and 50.29-61.27 kg ha-1 K2O. The fertilizer combination that resulted in the maximum yield was 62.98 kg ha-1 N, 47.04 kg ha-1 P2O5 and 59.95 kg ha-1 K2O (N:P2O5:K2O = 1:0.75:0.95), which produced the model-expected yield in trials at multiple sites. An economical fertilizer combination was determined on the basis of the best fertilizer measures in consideration of the cost of fertilizer and seed; this combination achieved yields of 2236.17 kg ha-1, the profit was 15,653.16 Yuan ha-1, and the corresponding rates were 57.60 kg ha-1 N, 47.03 kg ha-1 P2O5, and 31.64 kg ha-1 K2O (N:P2O5:K2O = 1:0.82:0.55).
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Clima Desértico , Fertilizantes , Nitrógeno/farmacología , Fósforo/farmacología , Potasio/farmacología , Vigna/crecimiento & desarrollo , China , Fertilizantes/economía , Modelos Teóricos , Análisis de Regresión , Vigna/efectos de los fármacosRESUMEN
Objective To investigate the effect of the laparotomy and laparoscopic surgery on the stress parameters and complication of patients with gastric cancer. Methods A total of 96 patients diagnosed as gastric cancer and treated by surgery in our hospital from January 2015 to January 2017 were divided into open operation group and laparoscopy group according to the operation method,48 cases in each group. Compared the operation time,bleeding volume,dissected lymph node number,postoperative hospitalization duration and anus exhausting time and complications in 6 months after surgery. The levels of WBC,CRP,TNF-α, IL-6 in serum before and after operation were detected by enzyme - linked immuno sorbent assay and compared. Results Compared with the open operation group, the bleeding volume,postoperative hospitalization duration and anus exhausting time of laparoscopy group were better with less dissected lymph node number and longer operation time, the differences were extremely significant(P ＜ 0. 01); the WBC,CRP,TNF-α, IL-6 levels of laparoscopy group at 1 day after the operation were lower than those of open operation group(P ＜ 0. 05). The incidence of complication of laparoscopy group was 22. 8％, which was less than 54. 7％ of control group, the difference was significant(P ＜ 0. 05). Conclusion Compared with the traditional open operation, laparoscopic radical gastrectomy can shorten the hospital stays and reduce the intraoperative blood loss, the stress response and complication rate after operation.
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Lignin can be a candidate as a charring agent applied in halogen-free flame retardant polymers, and incorporation of silicon and nitrogen elements in lignin can benefit to enhancing its thermal stability and charring ability. In the present work, wheat straw alkali lignin (Lig) was modified to incorporate silicon and nitrogen elements by γ-divinyl-3-aminopropyltriethoxysilane, and the modified lignin (CLig) was combined with ammonium polyphosphate (APP) as intumescent flame retardant to be applied in poly(Lactic acid) (PLA). The flame retardancy, combustion behavior and thermal stability of PLA composites were studied by the limited oxygen index (LOI), vertical burning testing (UL-94), cone calorimetry testing (CCT) and thermogravimetric analysis (TGA), respectively. The results showed a significant synergistic effect between CLig and APP in flame retarded PLA (PLA/APP/CLig) occured, and the PLA/APP/CLig had better flame retardancy. CCT data analysis revealed that CLig and APP largely reduced the peak heat release rate (PHRR) and total heat release rate (THR) of PLA, indicating their effectiveness in decreasing the combustion of PLA. TGA results exhibited that APP and CLig improved the thermal stability of PLA at high temperature. The analysis of morphology and structure of residual char indicated that a continuous, compact and intumescent char layer on the material surface formed during firing, and had higher graphitization degree. Mechanical properties data showed that PLA/APP/CLig had higher tensile strength as well as elongation at break.
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Carbon dioxide (CO2 ) and hydrogen sulfide (H2 S) are generally concomitant with methane (CH4 ) in natural gas and traditionally deemed useless or even harmful. Developing strategies that can simultaneously convert both CO2 and H2 S into value-added products is attractive; however it has not received enough attention. A solar-driven electrochemical process is demonstrated using graphene-encapsulated zinc oxide catalyst for CO2 reduction and graphene catalyst for H2 S oxidation mediated by EDTA-Fe2+ /EDTA-Fe3+ redox couples. The as-prepared solar-driven electrochemical system can realize the simultaneous conversion of CO2 and H2 S into carbon monoxide and elemental sulfur at near neutral conditions with high stability and selectivity. This conceptually provides an alternative avenue for the purification of natural gas with added economic and environmental benefits.
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Myocardial fibrosis leads to cardiac remodeling and heart failure after myocardial infarction .The mechanism of ven-tricular remodeling after myocardial infarction is complicated , which results from multi-factor interactions .TGF-β1-dependent Smads signal pathway is a definite mechanism which plays an important role in the process of myocardial fibrosis .Myocardial infarction activates the TGF-β1, which links the downstream Smads signaling to play a sustained biological effects via the ac-cumulation of activated cardiac fibroblasts and excess deposition of extracellular matrix , and the differentiation from myocardial fibroblasts to myofibroblasts .Therefore, how to block or control TGF-β1/Smads signaling pathway is an important research di-rection for the treatment of myocardial fibrosis after myocardial infarction.This paper reviews the current studies of the treat-ment of myocardial fibrosis after myocardial infarction based on the TGF-β1/Smads signaling pathway .