RESUMEN
The endocannabinoid system (ECS) is one of the most crucial systems in the human organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of physiological processes, including nociception, mood regulation, cognitive functions, neurogenesis and neuroprotection, appetite, lipid metabolism, as well as cell growth and proliferation. Thus, ECS proteins, including cannabinoid receptors and their endogenous ligands' synthesizing and degrading enzymes, are promising therapeutic targets. Their modulation has been employed in or extensively studied as a treatment of multiple diseases. However, due to a complex nature of ECS and its crosstalk with other biological systems, the development of novel drugs turned out to be a challenging task. In this review, we summarize potential therapeutic applications for ECS-targeting drugs, especially focusing on promising synthetic compounds and preclinical studies. We put emphasis on modulation of specific proteins of ECS in different pathophysiological areas. In addition, we stress possible difficulties and risks and highlight proposed solutions. By presenting this review, we point out information pivotal in the spotlight of ECS-targeting drug design, as well as provide an overview of the current state of knowledge on ECS-related pharmacodynamics and show possible directions for needed research.
Asunto(s)
Diseño de Fármacos , Receptores de Cannabinoides/metabolismo , Ansiedad/tratamiento farmacológico , Ansiedad/metabolismo , Agonistas de Receptores de Cannabinoides/química , Agonistas de Receptores de Cannabinoides/uso terapéutico , Antagonistas de Receptores de Cannabinoides/química , Antagonistas de Receptores de Cannabinoides/uso terapéutico , Depresión/tratamiento farmacológico , Depresión/metabolismo , Humanos , Enfermedades Neurodegenerativas/tratamiento farmacológico , Enfermedades Neurodegenerativas/metabolismo , Dolor/tratamiento farmacológico , Dolor/metabolismo , Receptores de Cannabinoides/química , Convulsiones/tratamiento farmacológico , Convulsiones/metabolismoRESUMEN
Stretchable polymer composites are a new group of materials with a wide range of application possibilities in wearable electronics. The purpose of this study was to fabricate stretchable electroluminescent (EL) structures using developed polymer compositions, based on multiple different nanomaterials: luminophore nanopowders, dielectric, carbon nanotubes, and conductive platelets. The multi-layered EL structures have been printed directly on textiles using screen printing technology. During research, the appropriate rheological properties of the developed composite pastes, and their suitability for printed electronics, have been confirmed. The structure that has been created from the developed materials has been tested in terms of its mechanical strength and resistance to washing or ironing.