RESUMEN

Angiotensin converting enzyme (ACE) is a candidate gene for psychiatric disorders. We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87). There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia. In a sample of nuclear families (n = 61) made up of one or more patients with schizophrenia recruited with their parents, there was no evidence for biased transmission of ACE I/D alleles. Particularly in the case of schizophrenia, these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined.

Asunto(s)

Discinesia Inducida por Medicamentos/genética , Trastornos del Humor/genética , Peptidil-Dipeptidasa A/genética , Esquizofrenia/genética , Alelos , Estudios de Casos y Controles , ADN/genética , Discinesia Inducida por Medicamentos/enzimología , Salud de la Familia , Femenino , Frecuencia de los Genes , Genotipo , Humanos , Masculino , Trastornos del Humor/enzimología , Mutagénesis Insercional , Polimorfismo Genético , Esquizofrenia/enzimología , Eliminación de Secuencia