RESUMEN
Cellular samples and subsequent cone biopsy samples from the same site in 18 patients were screened for infection with human papillomavirus (HPV) types 16 and 18 (HPV 16/18) by DNA hybridization. Filter hybridization of cells collected using cervical swabs was significantly less sensitive (with only 4 positive results) in detecting HPV 16/18 DNA sequences than was in situ hybridization of tissue sections (with 16 positive results). The in situ hybridization results correlated well with the cytologic and histologic findings of cervical intraepithelial neoplasia of grades II (mild dysplasia) and III (severe dysplasia and carcinoma in situ).
Asunto(s)
Cuello del Útero/microbiología , ADN Viral/análisis , Papillomaviridae/aislamiento & purificación , Infecciones Tumorales por Virus/diagnóstico , Autorradiografía , Biopsia , Cuello del Útero/citología , Femenino , Humanos , Hibridación de Ácido Nucleico , Papillomaviridae/genética , Neoplasias del Cuello Uterino/microbiologíaAsunto(s)
Infecciones por Adenoviridae/patología , Infecciones por Adenovirus Humanos/patología , Adenovirus Humanos/aislamiento & purificación , ADN Viral/aislamiento & purificación , Hibridación de Ácido Nucleico , Papillomaviridae/aislamiento & purificación , Infecciones Tumorales por Virus/patología , Neoplasias del Cuello Uterino/patología , Tonsila Faríngea/patología , Adulto , Secuencia de Bases , Cuello del Útero/patología , Femenino , Humanos , Persona de Mediana EdadRESUMEN
MCA is a tissue adhesive which can be delivered transcervically to the Fallopian tubes by means of the FEMCEPT device. In the patients treated with this system, both prior to hysterectomy and on an ambulatory basis, there have been no significant complications or side effects. In the most recent series of ambulatory patients treated with the REMCEPT-MCA system, the bilateral tubal closure rate was 78%.
PIP: Clinical trials of methylcyanoacrylate (MCA), a tissue adhesive injected to occlude fallopian tubes for tubal sterilization, were conducted in ambulatory patients and are presented. 3 small series of patients are described; most received .4-ml injections, but 23 of the 131 total subjects received .6-ml injections. Outcome was determined by hysterosalpingography. Bilateral closure rate after 1 treatment in series 1 (n=28) was 64%. In the 2nd series the bilateral closure rate was 54% after 1 injection; after a 2nd injection in the 2nd series, the rate was 78%, but overall the closure rate for this group after 2 injections was 65% (n=102). In the 3rd series, bilateral closure rate was 78% after 1 injection; this series used .6-ml injections and represents a dramatic improvement over the preceding series. Complications include pain at site of injection, mild to moderate cramping, and transient vagal reaction. The procedure takes 5 minutes or less. 2 uterine pregnancies have occurred to date, and no ectopic pregnancies were reported. MCA is a low-viscosity fluid in a monomeric form which rapidly polymerizes when placed in contact with body fluids.
Asunto(s)
Cianoacrilatos , Esterilización Tubaria/métodos , Adhesivos Tisulares , Atención Ambulatoria , Ensayos Clínicos como Asunto , Cianoacrilatos/administración & dosificación , Femenino , Humanos , Adhesivos Tisulares/administración & dosificaciónAsunto(s)
Colorantes , Trompas Uterinas , Histerectomía , Cianoacrilatos , Femenino , Humanos , ViscosidadRESUMEN
In a prospective study the interrelations between the sexual history of young women and the results of cervix smears were investigated. The main interest was focused on females bearing a high risk of developing a carcinoma of the cervix due to their sexual behaviour. 569 volunteers up to the age of 25 underwent vaginal examination and subsequently ecto- and endocervical smears were performed. Information about the sexual life was obtained using a questionnaire. These data as well as the results of the smears were stored and analyzed by a computer. The results were compared with references in the literature. They reveal some new aspects of sexuality in young people. The median age of the menarche in this investigation was 12,7 years in correspondence with the literature. The age of the first coitus was found to be in the range reported by other authors. Another point of interest was the use of oral contraceptives in respect to possible epithelial changes of the cervix. Practising oral contraception, the relation between contraceptives of the combined type and the sequential type was 10:1. Most young females discontinue the use of oral contraceptives at least once a year usually for a period of 2 months. The majority of young women had coital experiences with only one partner. A tendency toward promiscuity was not discernible. Inspite of coital experience, a substantial number (15,1%) did not practice any kind of contraception. Besides the use of oral contraceptives (81%), temporary experience with physical (37,2%) and chemical methods (19,8%) were reported. Nearly half of the pregnancies stated in the questionnaires were interrupted. The incidence of contamination with trichomonas and candida was reduced in comparison with the literature. According to results reported by other authors, a higher frequency of positive smears was expected. Among 569 samples, only one smear Pap. III D was found in a 20 year old girl with inconspicious sexual history. Women under the age of 25 years belonging to the risk group should be included in routine check-up with cervical smears.
Asunto(s)
Coito , Frotis Vaginal , Adolescente , Adulto , Factores de Edad , Anticonceptivos Orales/efectos adversos , Femenino , Humanos , Menarquia , Encuestas y Cuestionarios , Factores de Tiempo , Neoplasias del Cuello Uterino/inducido químicamente , Neoplasias del Cuello Uterino/diagnóstico , Neoplasias del Cuello Uterino/etiologíaRESUMEN
From 1967 to 1974 vaginal and cervical smears of about 46,000 teenage girls and young women up to the age of 25 were examined. Among these were 250 doubtful and positive cases (0,54%). Of the 67 positive ones 46 cases were known to be histologically examined (69%); 8 times an invasive carcinoma and 38 times a carcinoma in situ were found. Women under the age of 25 should therefore be included in routine check-up with cervical and vaginal smears.