RESUMEN
BACKGROUND: Barrett esophagus (BE) is considered precursor condition of esophageal adenocarcinoma. Its incidence and prevalence are increasing in general population. Studies reported that metabolic syndrome (MS) or diabetes mellitus (DM) is related to increased risk of BE. Current study was to assess and better understand the relationship between MS /DM and BE. METHODS: Electronic search was conducted in the database Pubmed/Medline (-December, 2015), Embase (-December, 2015), Cochrane Library (-December, 2015), and Web of Knowledge (-December, 2015). Studies included were assessed with summary odds ratios (ORs) with 95% confidence intervals (CIs) and compared exposure group with control group. The heterogeneity was examined by the funnel plot and the Egger's test. Subgroup analyses and sensitive analyses were performed for the detection of possible heterogeneity and impact on stability of analysis results. RESULTS: Twelve publications met the criteria and included 355,311 subjects were analyzed. The pooled results showed MS was closely associated with increased risk of BE (ORâ=â1.23; 95%CI 1.03-1.47; Pâ=â0.024), and yet DM did not significantly increase the risk of BE (ORâ=â1.07; 95%CI 0.82-1.38; Pâ=â0.627). Substantial heterogeneities were detected. No significant publication bias was detected by Egger's test (Pâ=â0.23). CONCLUSIONS: Based on the results of current meta-analysis, MS is associated with increased risk of BE. Further long-term follow-up prospective study needs to verify the current results, and definite pathophysiological mechanism needs to be further investigated and clearly elucidated.
Asunto(s)
Esófago de Barrett/epidemiología , Esófago de Barrett/fisiopatología , Síndrome Metabólico/epidemiología , Síndrome Metabólico/fisiopatología , Distribución por Edad , Anciano , China/epidemiología , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Estudios Observacionales como Asunto , Pronóstico , Ensayos Clínicos Controlados Aleatorios como Asunto , Índice de Severidad de la Enfermedad , Distribución por SexoRESUMEN
OBJECTIVE: To explore the association of CCR5δ32, CCR2-64I and SDFl-3 A gene polymorphisms with HIV-1-infection in Chinese population. METHODS: A meta-analysis was performed to identify case-control studies of CCR5δ32, CCR2-64I and SDFl-3 A polymorphisms from the literatures. RESULTS: Fourteen studies of CCR5δ32 were found, involving a total of 1607 cases and 1632 controls. Compared with the wild-type homozygote wt/wt, the pooled odds ratios (95%CI) of wt/mt, mt/mt, and wt/mt+mt/mt genotypes of CCR5δ32 gene polymorphisms were 1.156 (0.808, 1.654), 0.997 (0.198, 5.022), and 1.149 (0.808, 1.634), respectively. Twelve studies of CCR2-64I were identified, including 1415 cases and 1239 controls. Compared with the wild-type homozygote wt/wt, the pooled odds ratios (95%CI) of wt/mt, mt/mt, and wt/mt+mt/mt genotypes of CCR2-64I gene polymorphisms were 1.005 (0.844, 1.197), 1.191 (0.808, 1.754), and 1.028 (0.870, 1.214), respectively. Ten studies of SDFl-3 A were found, involving 1179 cases and 1003 controls. Compared with the wild-type homozygote wt/wt, the pooled odds ratios (95%CI) of wt/mt, mt/mt, and wt/mt + mt/mt genotypes of SDF1-3 A gene polymorphisms were 1.010 (0.830, 1.228), 1.188 (0.860, 1.643), and 1.038 (0.861, 1.250). CONCLUSION: CCR5δ32, CCR2-64I and SDFl-3 A gene polymorphisms do not show strong correlations to HIV-1-infection in Chinese population. These 3 genes may not have protective effect against HIV-1 infection in Chinese population, suggesting the susceptibility of Chinese population to the infection.
Asunto(s)
Quimiocina CXCL12/genética , Infecciones por VIH/genética , Polimorfismo Genético , Receptores CCR2/genética , Receptores CCR5/genética , Alelos , Pueblo Asiatico/genética , Frecuencia de los Genes , Genotipo , VIH-1 , HumanosRESUMEN
OBJECTIVE: To observe the inhibitory effect of resveratrol against the cytopathogenicity of enterovirus type 71. METHODS: The cytotoxicity of resveratrol on Vero cells was detected using cell counting kit-8 (CCK-8). The antiviral activity of resveratrol in different stages of infection, with ribavirin as the control, was evaluated by determining the virus inhibition rate, medium effective concentration (IC(50)), and selection index (SI). RESULTS: Resveratrol was nonpoisonous to Vero cells with an median toxic concentration (TC50) of 307.6 mmol/L. Resveratrol produced an obvious inhibitory effect against enterovirus type 71 only before the cell infection by the virus (IC(50)=20.2 mmol/L , SI=15.2), and once the cells were infected, resveratrol no longer had such antiviral effect. CONCLUSIONS: Resveratrol may offer some protection against enterovirus type 71 in vitro.
Asunto(s)
Antivirales/farmacología , Medicamentos Herbarios Chinos/farmacología , Enterovirus/efectos de los fármacos , Estilbenos/farmacología , Animales , Chlorocebus aethiops , Resveratrol , Células VeroRESUMEN
OBJECTIVE: Serum p53 protein overexpression was detected in population exposed to traffic exhaust gas to study the relation between traffic exhaust gas and the increased risk in p53 gene mutation. METHODS: Serum p53 protein expression was measured by enzyme-linked immunosorbent assay. Relationship between different types of job and serum p53 protein overexpression were studied by pearson Chi-square tests. RESULTS: Results on serum p53 protein overexpression on jobs outside of office (5.74%) were not significantly higher than jobs inside the office. However, it suggested that traffic police men (12.12%) working outside of office, with whose length of service longer than 30 years had a significant overexpression of serum p53 protein than the others (5.36%) whose length of service was less than 30 years (P < 0.05, OR = 2.43, 95% CI: 1.11 - 5.33). Overexpression rate of p53 protein appeared to be 6.89% in the group whose average weekly exposure hours were more than 40 hours, which was significant higher than the group whose exposed hours were less than 40 hours (P < 0.05, OR = 1.71, 95% CI: 1.03 - 2.81). CONCLUSION: The result suggested that traffic exhaust gas was likely to cause mutation of p53 gene and increasing the incidence of lung cancer.
Asunto(s)
Neoplasias Pulmonares/etiología , Exposición Profesional , Proteína p53 Supresora de Tumor/sangre , Emisiones de Vehículos/efectos adversos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Genes p53 , Humanos , Masculino , Persona de Mediana Edad , MutaciónRESUMEN
OBJECTIVE: To investigate the adaptability and psychological health status of the students from the military medical universities enrolled in the medical support service for military training on the sea, so as to provide more pertinent and specific psychological advice for students in military medical universities. METHODS: The psychological health status of 139 students were assessed by issuing a self-rating symptom scale (SCL-90) before the training and later before the maneuvers commenced, respectively. RESULTS: Except for obsessive-compulsive and interpersonal sensitivity factors, significant increases were recorded in the scores for other factors immediately before the maneuvers as compared with those recorded before the training (P<0.01, P<0.05). The positive symptom rates of various factors measured before the maneuvers were also higher. CONCLUSIONS: It is the essential task for daily psychological health education to help the students foster psychological self-regulation ability and cope with stresses to strengthen their psychological well-being. Building self-confidence, improving the adaptability and conquering fears should be the primary concern of the psychological advisors before military actions.