RESUMEN

Chronic diabetic wounds present formidable challenges, marked by uncontrolled bacterial infections, prolonged inflammation, and impaired angiogenesis. The evolving landscape of photo-responsive antibacterial therapy holds great promise in addressing these multifaceted issues, with a particular focus on leveraging the distinctive properties of 2D heterojunction materials. In this investigation, we engineered composite sprayed hydrogels, seamlessly integrating Bi/MoS2 nano-heterojunctions. Capitalizing on the synergistic interplay between photocatalytic antibacterial and photothermal antibacterial mechanisms, the Bi/MoS2 heterojunction, guided by its localized surface plasmon resonance, demonstrated outstanding antibacterial efficacy within a mere 10-minute exposure to 808 nm near-infrared light. This accelerated sterilization both in vitro and in vivo, consequently expediting wound healing. The sprayed composite gel not only furnishes protective shielding for skin tissues but also fosters endothelial cell proliferation, vascularization, and angiogenesis. This safe and ultrafast sterilizing hydrogel presents immense potential for application in antimicrobial dressings, thereby offering a promising avenue for diabetic wound healing.

Asunto(s)

RESUMEN

This work utilizes a handheld electrospinning device to prepare a novel nanofibrous composite membrane in situ for packaging freshness. It can realize pick-and-pack and is easy to operate. The nanofibrous membrane is based on PVB as the matrix material, adding Camellia oil (CO) and ZnO-TiO2 composite nanoparticles (ZT) as the active material. The antimicrobial property of the CO and the photocatalytic activity of the nanoparticles give the material good antimicrobial and ethylene degradation functions. Meanwhile, this nanofibrous membrane has good mechanical properties, suitable moisture permeability and good optical properties. The nanofibrous membrane are suitable for both climacteric and non- climacteric fruits. Its use as a cling film extends the shelf life of strawberries by 4 days and significantly slows the ripening of small tomatoes. Therefore, this nanofibrous membrane has great potential for application in the field of fruit preservation.

Asunto(s)

RESUMEN

Introduction: Despite the absence of definitive evidence indicating that the cp4-epsps gene and its resultant recombinant proteins have significant harmful effects on either human or animal health, the safety assessment of genetically modified (GM) crops expressing the CP4-EPSPS proteins has been controversial. This study endeavor was aimed at evaluating the potential risks posed by the CP4-EPSPS protein in transgenic crops, thereby contributing to the advancement of risk assessment methodologies in the context of genetically engineered crops. Methods: To ascertain the appropriate daily dosages for oral gavage administration, the expression levels of the CP4-EPSPS protein in a recombinant yeast were quantified. Subsequently, physiological and biochemical analysis, metabolomics, and metagenomic analysis were conducted based on a 90-day Sprague-Dawley (SD) rats feeding experiment, respectively, thereby enhancing the depth and precision of our risk assessment framework. Results: The results from the physiological and biochemical analysis, organ pathological, blood metabolism, gut microbiota, and correlation analysis of metabolites and gut microbiota revealed several biomarkers for further risk assessment. These biomarkers include clinical biochemical indexes such as total bilirubin (TBIL), direct bilirubin (DBIL), creatine kinase (CK), and lactate dehydrogenase (LDH); metabolites like Methionine, 2-Oxovaleric acid, and LysoPC (16:0); and gut microbiota including Blautia wexlerae, Holdemanella biformis, Dorea sp. CAG 317, Coriobacteriaceae and Erysipelotrichaceae. Conclusion: In conclusion, the risk can be significantly reduced by directly consuming inactivated recombinant CP4-EPSPS. Therefore, in everyday life, the risk associated with consuming GM foods containing recombinant CP4-EPSPS is substantially reduced after heat treatment.

RESUMEN

Near-field direct-writing electrospinning technology can be used to produce ordered micro/nanofiber membrane dressings. The application of this technology can simply realize the control of dressing porosity, compound different functional substances, and adjust their distribution, thus improving the defects of common dressings such as insufficient breathability, poor moisture retention performance, and single function. Herein, a novel multifunctional wound dressing was prepared to utilize near-field direct-writing electrospinning technology, in which calf skin collagen type I (CSC-I) and polycaprolactone (PCL) were used as the composite matrix, Hexafluoroisopropanol (HFIP) as the solvent, and erythromycin (ERY) as an anti-infective drug component. The results show that the micro/nanofiber membranes prepared by near-field direct-writing electrospinning technology can all present a complete mesh structure, excellent thermal stability, and good moisturizing properties. Moreover, the composite fiber membrane loaded with ERY not only had obvious antibacterial properties against E. coli and S. thermophilus but also a better slow-release function of drugs (it is rare to have both in traditional wound dressings). Therefore, this experimental design can provide relevant theories and an experimental foundation for preparing a new type of medical dressing with drug loading and has good guiding significance for the application and promotion of near-field direct-writing electrospinning in medical dressings.

RESUMEN

In this study, a novel Fe-based nanomaterial catalyst (Fe0/FeS) was synthesized via a self-heating process and employed to explore its impact on the formation of humic substances and the mitigation of microplastics. The results reveal that Fe0/FeS exhibited a significant increase in humic acid content (71.01 mg kg-1). Similarly, the formation of humic substances resulted in a higher humification index (4.91). Moreover, the addition of Fe0/FeS accelerated the degradation of microplastics (MPs), resulting in a lower concentration of MPs (9487 particles/kg) compared to the control experiments (22792 particles/kg). Fe0/FeS significantly increased the abundance of medium-sized MPs (50-200 µm) and reduced the abundance of small-sized (10-50 µm) and large-sized MPs (>1000 µm). These results can be attributed to the Fe0/FeS regulating the ▪OH production and specific microorganisms to promote humic substance formation and the degradation of MPs. This study proposes a feasible strategy to improve composting characteristics and reduce contaminants.

Asunto(s)

RESUMEN

A diabetic wound is a typical chronic wound with a long repair process and poor healing effects. It is an effective way to promote diabetic wound healing to design electrospinning nanofiber films with drug-assisted therapy, good air permeability and, a multilayer functional structure. In this paper, a diabetic wound dressing with a "sandwich-like" structure was designed. Metformin hydrochloride, loaded in the hydrophilic PVA inner layer, could effectively promote diabetic wound healing. The drug release was slowed down by osmosis. The laminate film dressing had good mechanical properties, with tensile strength and elongation at break reaching 5.91 MPa and 90.47 %, respectively, which was close to human skin. The laminate film loaded with erythromycin and puerarin in the hydrophobic PLA outer layer had good antibacterial properties. In addition, due to the high specific surface of the electrostatic spun film, it exhibited high water vapor permeability. It facilitates the gas exchange between the wound and the outside world. The cell experiments proved that the laminate film dressing had good biocompatibility. There was no toxic side effect on cell proliferation. In the diabetic animal wound model, it was shown that the closure rate of diabetic wound repair by laminate film reached 91.11 % in the second week. Our results suggest that the "sandwich-like" nanofiber film dressing could effectively promote the healing process and meet the various requirements of diabetic wound dressing as a promising candidate for future clinical application of chronic wound dressings.

Asunto(s)

RESUMEN

Bacterial and fungal contamination have become major factors in fruit spoilage and damage, posing a potential risk to human health. In this work, polylactic acid (PLA) nanofibers combined with Ag2O-hemp fibers for a good antimicrobial effect were developed and applied to antimicrobial fruit fresh-keeping packages. The results of molecular simulation calculations showed that the strength of hydrogen bonds between Ag2O and hemp fibers reached 45.522 kJ·mol-1, which proved that Ag2O and with hemp fibers formed a stable deposition. The Ag2O-hemp fibers modified electrospun polylactic acid nanofibrous composite film exhibited favorable mechanical properties. The tensile strength reached 5.23 ± 0.05 MPa and the elongation at break reached 105.56 ± 3.95 %. The obtained nanofibrous composite film has good antibacterial activity against E. coli, S. aureus, A. niger, and Penicillium, which indicated that they could effectively inhibit the growth of bacteria and fungi. The cell experiments proved that the nanofibrous composite film had good biocompatibility with a cell survival rate of 100 %. The experimental results on the fresh-keeping of red grapes showed that the PLA nanofibrous composite film modified by the Ag2O-hemp fibers could effectively prolong the spoilage time of red grapes at room temperature. Compared with the blank group, the freshness period of PLA nanofiber film modified by Ag2O-hemp fibers could be extended for more than 5 days. The hardness of 15 days (1.94 ± 0.19 × 105 Pa) was basically the same as that of 1 day (2.05 ± 0.06 × 105 Pa). The results were superior to commercially available PE preservation films. The above research results indicated that the Ag2O-hemp fibers modified PLA nanofibrous composite film had potential application prospects in the field of fruit fresh-keeping package.

Asunto(s)

RESUMEN

Poly(ε-caprolactone) (PCL)-incorporated lignin-chitosan biomass-based nanocomposite porous scaffolds have been effectively prepared by templating oil-in-water Pickering high internal phase emulsions (HIPEs). PCL is dissolved in oil and chitosan and lignin nanoparticles originate in water. The continuous phase of the emulsions is gelled by cross-linking of chitosan with genipin and then freeze-dried to obtain porous scaffolds. The resulting scaffolds display interconnected and tunable pore structures. An increase in PCL content increases the mechanical strength and greatly reduces the water absorption capacity of the scaffolds. Scaffolds loaded with the anti-bacterial drug enrofloxacin show a slow drug release profile, adjustable release rate, and favorable long-term anti-bacterial activity. Moreover, Pickering emulsion templates with suitable viscosity are used as 3D printing inks to construct porous scaffolds with personalized geometry. The results imply that the simplicity and versatility of the technique of combining freeze-drying with Pickering HIPE templates is a promising approach to fabricate hydrophobic biopolymer-incorporated biomass-based nanocomposite porous scaffolds for biomedical applications.

RESUMEN

As the most commonly used additive manufacturing technology, fused deposition modeling (FDM) still faces some technical issues caused by temperature change-induced unsteady thermal stress and warping. These issues can further lead to the deformation of printed parts and even terminate the printing process. In response to these issues, this article established a numerical model of temperature field and thermal stress field for FDM by finite element modeling and "birth-death element" technique to predict the deformation of the part. What makes sense in this process is that the logic of elements sort based on ANSYS Parametric Design Language (APDL) was proposed to sort the meshed elements, which was aimed to perform FDM simulation quickly on the model. In this work, the effects of the sheets shape and infill line directions (ILDs) on the distortion during FDM were simulated and verified. From the analysis of stress field and deformation nephogram, the simulation results indicated that ILD had greater effects on the distortion. Moreover, the sheet warping became most serious when the ILD was aligned with the diagonal of the sheet. The simulation results matched well with the experimental results. Thus, the proposed method in this work can be used to optimize the printing parameters for FDM process.

RESUMEN

To promote natural waste resource utilization, a novel biocomposite, composed of waste crab shells and poly (lactic acid) matrix, was developed by combining chemical treatment and 3D printing. A crab shell powder (ISCSP) with an abundant porous structure and a high specific surface area was obtained by treatment with hydrochloric acid and sodium hydroxide. Importantly, under the optimal printing parameters determined by the finite element analysis, test samples, and porous bones were successfully printed using CSP/PLA composites by a commercial fused deposition modeling (FDM) 3D printer. The morphology, mechanical and thermal properties, antibacterial properties, and biocompatibility of the CSP/PLA composites were then assessed. Our results revealed that the tensile strength and flexural strength of the ISCSP/PLA composites reached 58.71 and 90.11 MPa, which were 28.6 % and 28.8 % higher than that of pure PLA, respectively. The glass transition and melting temperatures of the composites remained similar to those of pure PLA. Interestingly, the addition of CSP increased PLA crystallinity, which could be attributed to the nucleation effect of CSP in the system. The antibacterial activity of the PLA-1.5ESCSP composite samples against Escherichia coli (E. coli) was greater than 99 %. More importantly, the live/dead assay showed that the CSP/PLA composites possessed excellent biocompatibility. Therefore, the developed CSP/PLA biocomposites are potential feedstocks for 3D printing in bone tissue engineering and may be used as graft substitutes in reparative and reconstructive surgery. They are especially beneficial due to their superior mechanical and thermal properties, excellent antibacterial activities, and significant biocompatibility.

Asunto(s)

RESUMEN

Public health safety issues have been plaguing the world since the pandemic outbreak of coronavirus disease (COVID-19). However, most personal protective equipments (PPE) do not have antibacterial and anti- toxicity effects. In this work, we designed and prepared a reusable, antibacterial and anti-toxicity Polyacrylonitrile (PAN) based nanofibrous membrane cooperated with Ag/g-C3N4 (Ag-CN), Myoporum.bontioides (M. bontioides) plant extracts and Ag nanoparticles (NPs) by an electrospinning-process. The SEM and TEM characterization revealed the formation of raised, creased or wrinkled areas on the fiber surface caused by the Ag nanoparticles, the rough surface prevented the aerosol particles on the fiber surface from sliding and stagnating, thus providing excellent filtration performance. The PAN/M. bontioides/Ag-CN/Ag nanofibrous membrane could be employed as a photocatalytic bactericidal material, which not only degraded 96.37% of methylene blue within 150 min, but also exhibited the superior bactericidal effect of 98.65 ± 1.49% and 97.8 ± 1.27% against E. coli and S. aureus, respectively, under 3 hs of light exposure. After 3 cycles of sterilization experiments, the PAN/M. bontioides/Ag-CN/Ag nanofibrous membrane maintained an efficient sterilization effect. Molecular docking revealed that the compounds in M. bontioides extracts interacted with neo-coronavirus targets mainly on Mpro and RdRp proteins, and these compounds had the strongest docking energy with Mpro protein, the shortest docking radius, and more binding sites for key amino acids around the viral protein targets, which influenced the replication and transcription process of neo-coronavirus. The PAN/M.bontioides/Ag-CN/Ag nanofibrous membrane also performed significant inhibition of influenza A virus H3N2. The novel nanofiber membrane is expected to be applied to medical masks, which will improve human isolation and protection against viruses.

RESUMEN

In this work, a functionalized polycaprolactone (PCL) composite fiber combining calf-type I collagen (CO) and natural drug usnic acid (UA) was prepared, in which UA was used as an antibacterial agent. Through 3D near-field electrospinning, the mixed solution was prepared into PCL/CO/UA composite fibers (PCUCF), which has a well-defined perfect arrangement structure. The influence of electrospinning process parameters on fiber diameter was investigated, the optimal electrospinning parameters were determined, and the electric field simulation was conducted to verify the optimal parameters. The addition of 20% collagen made the composite fiber have good hydrophilicity and water absorption property. In the presence of PCUCF, 1% UA content significantly inhibited the growth rate of Gram-positive and negative bacteria in the plate culture. The AC-PCUCF (after crosslinking PCUCF) prepared by crosslinking collagen with genipin showed stronger mechanical properties, water absorption property, thermal stability, and drug release performance. Cell proliferation experiments showed that PCUCF and AC-PCUCF had no cytotoxicity and could promote cell proliferation and adhesion. The results show that PCL/CO/UA composite fiber has potential application prospects in biomedical dressing.

RESUMEN

Fluid bath-assisted three-dimensional (3D) printing is an innovative 3D printing strategy that extrudes liquid ink materials into a fluid bath to form various 3D configurations. Since the support bath can provide in situ support, extruded filaments are able to freely construct complex 3D structures. Meanwhile, the supporting function of the fluid bath decreases the dependence of the ink material's cross-linkability, thus broadening the material selections for biomedical applications. Fluid bath-assisted 3D printing can be divided into two subcategories: embedded 3D printing and support bath-enabled 3D printing. This review will introduce and discuss three main manufacturing processes, or stages, for these two strategies. The stages that will be discussed include preprinting, printing, and postprinting. In the preprinting stage, representative fluid bath materials are introduced and the bath material preparation methods are also discussed. In addition, the design criteria of fluid bath materials including biocompatibility, rheological properties, physical/chemical stability, hydrophilicity/hydrophobicity, and other properties are proposed in order to guide the selection and design of future fluid bath materials. For the printing stage, some key technical issues discussed in this review include filament formation mechanisms in a fluid bath, effects of nozzle movement on printed structures, and design strategies for printing paths. In the postprinting stage, some commonly used postprinting processes are introduced. Finally, representative biomedical applications of fluid bath-assisted 3D printing, such as standalone organoids/tissues, biomedical microfluidic devices, and wearable and bionic devices, are summarized and presented.

Asunto(s)

RESUMEN

Step-scheme (S-scheme) photocatalysts have been proposed for highly efficient charge separation and strong redox activity in the photocatalysis field. Here, we reported a facile strategy to obtain the S-scheme heterojunction composite TiO2/chlorophyll (Chl). The S-scheme heterojunction enables the significant improvement of electron transfer efficiency at the interfacial heterojunction of TiO2/Chl. Also, the lifted conduction band and valence band of TiO2/Chl resulted in more than 1.61 times generation of reactive oxidizing species, compared to that of bare TiO2. In addition, TiO2/Chl was applied as a photocatalytic bactericidal material to fabricate commercial masks for prolonged life span of the mask. The TiO2/Chl-coated mask filter exhibited excellent bactericidal effect on Escherichia coli under light illumination (2.94 × 107 cfu E. coli were killed by 1 cm-2 coated mask filters within illumination of 3 h), while commercial mask filters showed no bactericidal effect. After three circulation-sterilization tests, the TiO2/Chl-made mask filter maintained the initial bactericidal effect, which greatly extended the life span of the mask that presents a promising strategy to alleviate the supply stress of masks.

Asunto(s)

RESUMEN

Currently, the degradation of organic pollutants in wastewater by photocatalytic technology has attracted great attention. In this study, a new type of 3D printing material with photocatalytic activity was first prepared to print a water treatment equipment, and then a layer of silver-loaded TiO2 was coated on the equipment to further improve the catalytic degradation performance. The composite filaments with a diameter of 1.75 ± 0.05 mm were prepared by a melt blending method, which contained 10 wt% of modified TiO2 and 90 wt% of PLA. The silver-loaded TiO2 was uniformly coated on the equipment through a UV-curing method. The final results showed that those modified particles were uniformly dispersed in the PLA matrix. The stable printing composite filaments could be produced when 10 wt% TiO2 was added to the PLA matrix. Moreover, the photocatalytic degradation performance could be effectively improved after 5 wt% of silver loading was added. This novel facility showed good degradability of organic compounds in wastewater and bactericidal effect, which had potential applications for the drinking water treatment in the future.

RESUMEN

Flexible aqueous battery is considered to be one of the most promising energy storage devices for powering flexible electronics. However, inferior interfacial compatibility in electrode-electrolyte interfaces and inefficient ionic channel of electrolytes usually result in potential troubles when applied in practical applications. Herein, we report a mild synthetic route to a sodium lignosulfonate-polyacrylamide hydrogel electrolyte with a high adhesiveness to achieve low electrode-electrolyte interfacial resistance and fast ionic conduction. Comprehensive experiments show that the catechol groups from sodium lignosulfonate demonstrate strong interactions with both cathode and anode materials, and thus greatly reduce the contact resistances across the electrodes. Meanwhile, the existence of sulfonate groups significantly enhances the ionic conductivity of the hydrogel electrolyte. Benefiting from this design, a low ohmic resistance of 3.8 Ω (i.e., 11.4 Ω cm2 ), a low charge transfer resistance of 22.5 Ω (i.e., 67.5 Ω cm2 ), a high ionic conductivity of 31.1 mS cm-1 as well as a 100% capacity retention upon harsh bending deformation can be realized in the flexible zinc ion battery, which are significantly superior to those in the traditional candidates. The present investigation provides new insight into addressing the interfacial issue plaguing flexible energy storage devices.

Asunto(s)

RESUMEN

Curcumin (Cur), appeared to provide huge potential in biomedical application. However, its therapeutic efficacy was greatly limited as the result of poor solubility and instability. To address these limitations, we create a new type of hollow mesoporous titania nanoparticle (HMTN) to encapsulate Cur. HMTN was decorated with a layer of hydrophilic polyethylenimine (PEI), which controlled the release rate of Cur inside the pore due to its dendritic structure. Combined with the folic acid (FA) mediated targeting effect, the potential multifunctional Cur loaded titania nanoparticle (Cur-FA-PEI-HMTN) showed excellent biocompatibility and bioavailability, as well as the UV-responsive drug release properties. The operating parameters to prepare hollow structure were studied and the Cur-FA-PEI-HMTN nanosystem had been fully characterized by Brunauer-Emmet-Teller, Fourier transform infrared spectroscopy, transmission electron microscope, thermal gravity analysis, differential thermal analysis, x-ray diffraction, dynamic light scattering and zeta potential. In addition, the hemolytic test, as well as CCK8, flow cytometry, Hoechst 33342 staining experiment, were carried out to confirm the low cytotoxity and high biocompatibility. The confocal microscopy analysis results also revealed the increasing uptake of Cur@FA-PEI-HMTN by MCF-7 cells. The synthesized nanoparticles displayed great potential as drug nanovehicles with high biocompatibility.

Asunto(s)

RESUMEN

In this work, aiming at a UV-curing 3D printing process with liquid crystal display (LCD) irradiation, a novel free-radical/cationic hybrid photosensitive resin was designed and prepared. After testing, the results showed that the acrylate monomers could be polymerized through a free-radical mechanism, while the epoxides were polymerized by a cationic curing mechanism. During the process of UV-curing, the acrylate and epoxide polymers were crosslinked and further locked together by non-covalent bonds. Therefore, an interpenetrating polymer network (IPN) structure could be formed through light-curing 3D-printing processes. Fourier transform infrared spectroscopy (FT-IR) revealed that the 3,4-epoxy cyclohexyl methyl-3,4-epoxy cyclohexyl formate and acrylic resin were both successfully involved in the UV-curing process. Furthermore, in order to make the 3D-printed objects cured completely, post-processing was of great importance. The results from the systematic study of the dynamic mechanical properties of the printed objects showed that the heating treatment process after UV irradiation was very necessary and favorable for the complete cationic polymerization of UV-6110 induced by Irgacure 261. The optimum heating treatment conditions were achieved at a temperature of 70 °C for 3 h.

RESUMEN

ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese Medicine (TCM) has been widely used as an approach worldwide. Chinese Medicines (CMs) had been used to treat and prevent viral infection pneumonia diseases for thousands of years and had accumulated a large number of clinical experiences and effective prescriptions. AIM OF THE STUDY: This research aimed to systematically excavate the classical prescriptions of Chinese Medicine (CM), which have been used to prevent and treat Pestilence (Wenbing, Wenyi, Shiyi or Yibing) for long history in China, to obtain the potential prescriptions and ingredients to alternatively treat COVID-19. MATERIALS AND METHODS: We developed the screening system based on data mining, molecular docking and network pharmacology. Data mining and association network were used to mine the high-frequency herbs and formulas from ancient prescriptions. Virtual screening for the effective components of high frequency CMs and compatibility Chinese Medicine was explored by a molecular docking approach. Furthermore, network pharmacology method was used to preliminarily uncover the molecule mechanism. RESULTS: 574 prescriptions were obtained from 96,606 classical prescriptions with the key words to treat "Warm diseases (Wenbing)", "Pestilence (Wenyi or Yibing)" or "Epidemic diseases (Shiyi)". Meanwhile, 40 kinds of CMs, 36 CMs-pairs, 6 triple-CMs-groups existed with high frequency among the 574 prescriptions. Additionally, the key targets of SARS-COV-2, namely 3CL hydrolase (Mpro) and angiotensin-converting enzyme 2(ACE2), were used to dock the main ingredients from the 40 kinds by the LigandFitDock method. A total of 66 compounds components with higher frequency were docked with the COVID-19 targets, which were distributed in 26 kinds of CMs, among which Gancao (Glycyrrhizae Radix Et Rhizoma), HuangQin (Scutellariae Radix), Dahuang (Rhei Radix Et Rhizome) and Chaihu (Bupleuri Radix) contain more potential compounds. Network pharmacology results showed that Gancao (Glycyrrhizae Radix Et Rhizoma) and HuangQin (Scutellariae Radix) CMs-pairs could also interact with the targets involving in immune and inflammation diseases. CONCLUSIONS: These results we obtained probably provided potential candidate CMs formulas or active ingredients to overcome COVID-19. Prospectively, animal experiment and rigorous clinic studies are needed to confirm the potential preventive and treat effect of these CMs and compounds.

Asunto(s)

RESUMEN

In this work, micrometer copper-zinc alloy particles-reinforced particleboard wood flour/poly (lactic acid) (mCu-Zn/PWF/PLA) wood plastic composites with high gloss and antibacterial properties for 3D printing were prepared by a melt blending process. The structure and properties of the composites with different contents of mCu-Zn were analyzed by means of mechanical testing, dynamic mechanical analysis, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, and antibacterial testing. The results showed that the mechanical properties, thermal stability, and antibacterial performance of the composites were significantly improved, as mCu-Zn was added into the wood plastic composites. When adding 2 wt.% mCu-Zn, the flexural strength of mCu-Zn/PWF/PLA composites (with 5 wt.% of particleboard wood flour) (PWF) increased by 47.1% compared with pure poly (lactic acid) (PLA), and 18.9% compared with PWF/PLA wood plastic composites. The surface gloss was increased by 1142.6% compared with PWF/PLA wood plastic composites. Furthermore, the inhibition rates of mCu-Zn/PWF/PLA composites against Escherichia coli reached 90.43%. Therefore, this novel high gloss and antibacterial wood plastic composites for fused deposition modeling (FDM) 3D printing have potential applications in personalized and classic furniture, art, toys, etc.