RESUMEN
Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.
Asunto(s)
Antineoplásicos Fitogénicos/uso terapéutico , Metástasis de la Neoplasia/tratamiento farmacológico , Polisacáridos/uso terapéutico , Animales , Catepsina B/metabolismo , Catepsina D/metabolismo , Catepsina L , Catepsinas/metabolismo , Ciclofosfamida/uso terapéutico , Cisteína Endopeptidasas/metabolismo , Sinergismo Farmacológico , Fucus/química , Neoplasias Pulmonares/secundario , Ratones , Ratones Endogámicos C57BL , Trasplante de Neoplasias , Neoplasias Experimentales/enzimología , Ésteres del Ácido Sulfúrico/uso terapéuticoRESUMEN
We measured plasma cystatin C concentration and activity of cathepsins B and L in tumor tissue as possible markers for the efficiency of antitumor therapy and prognostic criteria for Lewis lung adenocarcinoma in mice. Plasma cystatin C concentration markedly decreased in mice with tumors. During successive therapy the increase in plasma cystatin C concentration correlated with the degree of inhibition of tumor growth. Activities of cathepsins B and L in the liver increased in animals with tumors. In mice receiving successive antitumor therapy activities of cathepsins B and L increased in tumor tissue, but decreased in the liver (compared to untreated animals).