Asunto(s)
Hiperfunción de las Glándulas Suprarrenales/genética , Hiperfunción de las Glándulas Suprarrenales/inmunología , Receptores de Glucocorticoides/genética , Receptores de Glucocorticoides/inmunología , Expresión Génica/genética , Humanos , Mutación Puntual/genética , Polimorfismo Genético/genéticaAsunto(s)
Síndrome de Bartter/complicaciones , Nefrocalcinosis/complicaciones , Ácido Úrico/sangre , Adulto , Síndrome de Bartter/sangre , Síndrome de Bartter/diagnóstico , Diagnóstico Diferencial , Progresión de la Enfermedad , Humanos , Fallo Renal Crónico/sangre , Fallo Renal Crónico/etiología , Masculino , Nefrocalcinosis/sangre , Nefrocalcinosis/diagnóstico , Estudios Retrospectivos , SíndromeAsunto(s)
Tirotoxicosis/diagnóstico , Antagonistas Adrenérgicos beta/administración & dosificación , Antitiroideos/administración & dosificación , Atenolol/administración & dosificación , Enfermedad Crónica , Diagnóstico Diferencial , Quimioterapia Combinada , Femenino , Enfermedad de Graves/diagnóstico , Humanos , Metimazol/administración & dosificación , Persona de Mediana Edad , Tirotoxicosis/tratamiento farmacológico , Tirotoxicosis/psicologíaRESUMEN
Thyroid pathology is among autoimmune diseases the incidence of which is now on the increase. Endocrine ophthalmology (EO) often accompanying thyroid disorders may cause deterioration or loss of vision. EO can be corrected by several methods. The most pronounced effect is achieved by x-ray therapy on the orbit and intermittent glucocorticosteroid (GCS) large-dose therapy. GCS, however, affect carbohydrate metabolism. In physiological levels, GCS effects on regulation of carbohydrate metabolism are not significant, but high GCS concentrations may provoke hyperglycemia and even steroid diabetes.
Asunto(s)
Complicaciones de la Diabetes , Glucocorticoides/uso terapéutico , Enfermedad de Graves/tratamiento farmacológico , Enfermedad de Graves/radioterapia , Adulto , Glucemia/metabolismo , Diabetes Mellitus/sangre , Femenino , Enfermedad de Graves/complicaciones , Humanos , Insulina/sangre , Masculino , Persona de Mediana Edad , Radioterapia AdyuvanteRESUMEN
Combined investigation of 200 patients with different thyroid lesions was conducted. The program of investigation included computerized echotomography of the thyroid with spot puncture and rapid cytological examination. Of them 138 patients were operated upon. In 125 patients (87.4%) combined investigation including spot aspiration puncture biopsy and echotomography helped to establish morphological diagnosis of lesion, to specify indications for surgical intervention and to optimize its use.
Asunto(s)
Enfermedades de la Tiroides/diagnóstico , Adenoma/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Biopsia con Aguja , Femenino , Bocio/diagnóstico , Humanos , Masculino , Enfermedades de la Tiroides/diagnóstico por imagen , Enfermedades de la Tiroides/patología , Neoplasias de la Tiroides/diagnóstico , Tiroiditis Autoinmune/diagnóstico , UltrasonografíaRESUMEN
The article presents data obtained in studying the content of calcium regulating hormone thyrocalcitonin and parathyroid hormone in blood plasma of patients with diffuse polyposis of the colon prior to and after a radical surgical treatment. The content of these hormones was also studied in extracts from colonic polyps. The concentration The concentration of thyrocalcitonin was found to decrease after operation. The elevated concentration of thyrocalcitonin was established in polyp extracts which might suggest its "ectopic secretion" in the polyp tissue in diffuse polyposis. Removal of the colon with polyps is followed by normalization of metabolism in the organism which proves the expediency of early surgical treatment.
Asunto(s)
Poliposis Adenomatosa del Colon/fisiopatología , Calcitonina/metabolismo , Calcio/metabolismo , Hormona Paratiroidea/metabolismo , Poliposis Adenomatosa del Colon/cirugía , Adolescente , Adulto , Calcitonina/fisiología , Gastrinas/metabolismo , Humanos , Insulina/metabolismo , Secreción de Insulina , Hormona Paratiroidea/fisiología , Periodo PosoperatorioRESUMEN
The use of various regimens of multiple insulin injections versus the regimen of a single injection resulted in more stable compensation of diabetes mellitus (glycemia stabilization), a decrease in insulin demand, smoothing over circadian glycemic variations, and correction of hypoglycemia. A choice of the number of injections and the time of administration depended on the type of a diabetic course, individual features of the patient's life style and work.
Asunto(s)
Diabetes Mellitus Tipo 1/tratamiento farmacológico , Insulina/administración & dosificación , Adolescente , Adulto , Relación Dosis-Respuesta a Droga , Humanos , Persona de Mediana EdadAsunto(s)
Diabetes Mellitus Tipo 1/complicaciones , Diabetes Mellitus Tipo 2/complicaciones , Enfermedades en Gemelos , Úlcera Péptica/etiología , Adulto , Diabetes Mellitus Tipo 1/genética , Diabetes Mellitus Tipo 2/genética , Susceptibilidad a Enfermedades , Femenino , Humanos , Masculino , Persona de Mediana Edad , Linaje , Gemelos MonocigóticosRESUMEN
A study was made of the parameters of central hemodynamics in 48 patients with hypothyroidism in various degrees of its compensation. Tetrapolar chest rheography was used for this purpose. The content of the blood thyroid hormones was determined by radioimmunoassay. The patients developed a hypokinetic blood circulation, correlating to a degree of severity of hypothyroidism. Significant correlation between the levels of the thyroid hormones and indices of central hemodynamics was found. The method of tetrapolar chest rheography was shown to be a reliable and noninvasive test for assessment of the adequacy of substitution therapy in hypothyroidism and myocardial sensitivity to the thyroid hormones.
Asunto(s)
Hemodinámica , Hipotiroidismo/fisiopatología , Adulto , Anciano , Femenino , Humanos , Hipotiroidismo/metabolismo , Masculino , Persona de Mediana Edad , Pletismografía de Impedancia , Tirotropina/sangre , Tiroxina/sangre , Triyodotironina/sangreAsunto(s)
Diabetes Mellitus Tipo 1/terapia , Diabetes Mellitus Tipo 2/terapia , Animales , Biguanidas/uso terapéutico , Dieta para Diabéticos , Fibras de la Dieta/administración & dosificación , Estudios de Evaluación como Asunto , Humanos , Sistemas de Infusión de Insulina , Sulfanilamidas/uso terapéutico , PorcinosRESUMEN
The authors discuss the advantages of the use of glucocorticoids in the treatment of autoimmune diseases, if the drugs are administered every other day. A total of 149 patients with autoimmune thyroiditis, endocrine ophthalmopathy, myasthenia and bronchial asthma were examined. Of these, 3 patients received glucocorticoids every other day, whereas the remainder took them every day. The former method consisted in the use of a single daily dose of glucocorticoids (20 to 80 mg) at 7 to 8 o'clock in the morning over 2 months to 5 years. The function of the pituitary-adrenal system was tested by the measurement of the blood content of ACTH, hydrocortisone and testosterone with the aid of a kit of standard tests. It was shown that glucocorticoids administered every other day did not produce any suppression of the pituitary-adrenal system in contrast to those who received prednisolone every day. The lack of the side effects in the form of exogenous hypercorticoidism can be explained by the anabolic action of steroid hormones produced by the reticular zone of the adrenal cortex. Examination of the blood serum content of testosterone in women who received glucocorticoids every other day has demonstrated that modulations in its secretion were similar to those in the content of ACTH and hydrocortisone. Thus, the stimulating hormonal therapy with glucocorticoids administered every other day appears more physiological as compared to the daily schedule.
Asunto(s)
Sistema Hipófiso-Suprarrenal/efectos de los fármacos , Prednisolona/administración & dosificación , Tiroiditis Autoinmune/tratamiento farmacológico , Adolescente , Hormona Adrenocorticotrópica/metabolismo , Adulto , Anciano , Asma/tratamiento farmacológico , Esquema de Medicación , Femenino , Enfermedad de Graves/tratamiento farmacológico , Humanos , Hidrocortisona/metabolismo , Masculino , Persona de Mediana Edad , Miastenia Gravis/tratamiento farmacológico , Sistema Hipófiso-Suprarrenal/metabolismoRESUMEN
Two cases of the apathetic form of thyrotoxicosis in women aged 39 and 54 were described. The disease was characterized by the absence of typical signs of thyrotoxicosis in the presence of ptosis, cardiovascular disorders and thyrotoxic myopathy confirmed by EMG findings. Clinical symptoms were not registered after surgical therapy or chemotherapy with mercazolyl.
Asunto(s)
Hipertiroidismo/patología , Adulto , Cara , Femenino , Humanos , Hipertiroidismo/diagnóstico , Hipertiroidismo/terapia , Metimazol/uso terapéutico , Persona de Mediana Edad , TiroidectomíaRESUMEN
The authors studied the basal and L-DOPA-stimulated levels of STH and basal level of prolactin in blood serum of 128 patients presenting with acromegaly. The basal levels of STH and prolactin were found to be elevated in the majority of patients with an active disease stage. Long-term (for 5-6 years) therapy with parlodel (2.5-20 mg a day) produced a disease remission. It is concluded that parlodel can be used not only as an additional agent to x-ray therapy or hypophysectomy but also as monotherapy, provided that the drug is applied for a long time.
Asunto(s)
Acromegalia/tratamiento farmacológico , Bromocriptina/uso terapéutico , Acromegalia/sangre , Adulto , Enfermedad Crónica , Evaluación de Medicamentos , Femenino , Hormona del Crecimiento/sangre , Humanos , Masculino , Persona de Mediana Edad , Prolactina/sangre , Factores de TiempoRESUMEN
The most informative diagnostic criteria of autoimmune thyroiditis were revealed. A kit of diagnostic tests were offered for each version of autoimmune thyroiditis. The lowest percentage of antibodies against thyroglobulin was demonstrated for the hyperthyroid hypertrophic version of autoimmune thyroiditis, while the highest for its atrophic pattern. Biopsy of the thyroid was found to be the most informative test for autoimmune thyroiditis, provided the result was positive. If the result of puncture biopsy is negative, it is desirable to apply a complex of tests depending on thyroid function and size.