RESUMEN
Haloperidol decanoate inj. (Janssen) á 150 mg was evaluated during long-term (max. 4.2 years) treatment of 30 sexual offenders. We proved that the drug was well tolerated also by non-psychotic patients by using of low doses (37.5 mg) with intervals between injections 6 weeks. Extrapyramidal side effects were on minimal level. "Side" effect on sexual functions and appetence turned to be the main effect of the drug. The influence on sexual reactivity was objectively examined by electrocapacitative phalloplethysmograph (Figar). There were detected the latency of initial phase of the PPG curve and prolongation of the incremental slope. The decremental slope of the PPG curve was shorter.
Asunto(s)
Antipsicóticos/uso terapéutico , Haloperidol/análogos & derivados , Trastornos Parafílicos/tratamiento farmacológico , Adulto , Haloperidol/uso terapéutico , Humanos , MasculinoRESUMEN
Haloperidol decanoate inj. (Janssen) á 150 mg was evaluated during long-term (max. 4 years) treatment of 24 schizophrenics. The drug was very good tolerated locally and generally. Only lower doses of drug was sufficient to keep stabilized clinical state during the maintenance therapy (37.5-75 mg) with intervals 4-6 weeks. The occurrence of side effects gradually decreased similarly as a necessity to use antiparkinsonics. The maintenance treatment helped the patients to resume their social and working positions - 68% restarted working.
Asunto(s)
Antipsicóticos/uso terapéutico , Haloperidol/análogos & derivados , Esquizofrenia/tratamiento farmacológico , Adulto , Femenino , Haloperidol/uso terapéutico , Humanos , MasculinoAsunto(s)
Antipsicóticos/administración & dosificación , Antipsicóticos/uso terapéutico , Haloperidol/administración & dosificación , Haloperidol/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Antipsicóticos/efectos adversos , Preparaciones de Acción Retardada , Electroencefalografía/efectos de los fármacos , Empleo , Haloperidol/efectos adversos , Humanos , Cuidados a Largo Plazo , Escalas de Valoración PsiquiátricaAsunto(s)
Haloperidol/uso terapéutico , Trastornos Psicóticos/tratamiento farmacológico , Esquizofrenia/tratamiento farmacológico , Delitos Sexuales , Adolescente , Adulto , Relación Dosis-Respuesta a Droga , Femenino , Haloperidol/efectos adversos , Humanos , Estudios Longitudinales , Masculino , Trastornos Psicóticos/fisiopatología , Esquizofrenia/fisiopatologíaRESUMEN
Maprotilin was given orally to 34 depressive patients for 3-6 weeks, or in daily morning i. v. infusions for 10-15 days to 23 patients, and in combined infusions with clomipramine to 32 patients. - At oral administration the effect was evident only after 10 days of treatment; most depressive symptoms improved. Maprotilin in infusions had a rapid onset of effect, being especially intensive on depressive mood and anxiety. The combined infusions of maprotilin and clomipramine affected an even wider range of symptoms. The factor anxiety somatization decreased significantly already after 7 days of treatment, more expressively after combined infusions. Side effects occurred only during the infusions.
Asunto(s)
Antracenos/uso terapéutico , Clomipramina/uso terapéutico , Trastorno Depresivo/tratamiento farmacológico , Maprotilina/uso terapéutico , Administración Oral , Adulto , Trastorno Depresivo/psicología , Quimioterapia Combinada , Femenino , Humanos , Infusiones Parenterales , Masculino , Persona de Mediana Edad , Escalas de Valoración PsiquiátricaAsunto(s)
Antidepresivos/administración & dosificación , Trastorno Depresivo/tratamiento farmacológico , Adulto , Carbazoles/administración & dosificación , Clomipramina/administración & dosificación , Dibenzazepinas/administración & dosificación , Femenino , Humanos , Infusiones Parenterales , Masculino , Maprotilina/administración & dosificación , Persona de Mediana EdadAsunto(s)
Trastornos Neuróticos/tratamiento farmacológico , Piperazinas/uso terapéutico , Adulto , Anciano , Fenómenos Químicos , Química , Depresión/tratamiento farmacológico , Femenino , Humanos , Masculino , Mesilatos/uso terapéutico , Persona de Mediana Edad , Neurastenia/tratamiento farmacológicoRESUMEN
In the present paper we studied the clinical effects of psychotropic drugs. In the experimental part we studied their effects on our patients and normal subjects and compared it with the results obtained with the placebo treatment. We studied the effect on attention (A), efficiency (E) psychomotor rate (PR), numerical quadrate, Bourdon test, tapping and some functions of the vegetative nervous system, the mean orthostatic acceleration (MOA), the clinostatic retardation (CR), the tonus of the sympathetic (TS) and of the vagus (TV). Sydnocarb is an effective psychostimulating agent. The is no evident influence on VN in doses between 5 and 15 mg (23 patients). It accelerated psychomotor rate (24 patients). E, A, PR are only slightly increased by Mephexamid (40 patients). Maprotiline (20) patients caused an increase in E, PR and slightly in A. Under the influence of Sydnocarb, Mephexamid and Maprotiline the value of MOA, CR, TS, TV remained unchanged. Clomipramin was administered in 20 patients in the experimental part and in 40 patients in the clinical part of our study. In the course of the clinical trial we discovered that Clomipramine decreased the irritability of the vegetative nervous system and through this effect causes deserved general sedation of the organism.