RESUMEN
A double-blind crossover study was performed to evaluate the bronchodilating effect of different single doses of procaterol (less than 0.5 micrograms/kg, 1.5 micrograms/kg, and placebo) orally administered. Sixteen asthmatic children, age 6-12 years, participated in the trial. Pulmonary function, heart rate, blood pressure, and tremor were evaluated at 30, 60, 90, and 120 min and then hourly for 8 hours after administration. All three doses were therapeutically effective. The 1.5 micrograms/kg dose produced a more sustained bronchodilatation effect, but was also associated with an increase in the incidence of tremors. The 0.5 micrograms/kg dosage may, however, be a good starting dose because it assures a reasonable risk/benefit ratio.
Asunto(s)
Asma/tratamiento farmacológico , Etanolaminas/administración & dosificación , Administración Oral , Asma/fisiopatología , Broncodilatadores , Niño , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Etanolaminas/efectos adversos , Etanolaminas/uso terapéutico , Volumen Espiratorio Forzado/efectos de los fármacos , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Flujo Espiratorio Medio Máximo/efectos de los fármacos , Procaterol , Factores de Tiempo , Temblor/inducido químicamente , Capacidad Vital/efectos de los fármacosRESUMEN
Bronchial hyperreactivity is a condition in which the airways show a much greater bronchoconstrictor response to provocative stimuli than normal. Non-specific bronchial hyperreactivity is a feature of asthmatic patients both allergic and non-allergic. It is proposed that bronchial hyperreactivity is due to the fact that the airways are narrower. In addition changes in the mass of muscle, and changes in the contractility of the muscle may contribute to bronchial hyperreactivity. Moreover bronchial hyperreactivity could be due to increased alpha-adrenergic or parasympathetic activity or to decreased beta-adrenergic or non adrenergic inhibitory activity. Bronchial hyperreactivity can be induced by factors such as infection, inflammation or exposure to allergens.