RESUMEN
The paper is concerned with the results of studying the concentration of circulating immune complexes and immune system (the number of lymphocyte populations and subpopulations in the peripheral blood, the level of serum immunoglobulins) in 45 patients aged 10 to 72 years with hemorrhagic vasculitis depending on the disease pattern and course before and after the treatment. The patients suffering from hemorrhagic vasculitis manifested appreciable changes in humoral immunity and negligible derangement of cellular immunity associated with dramatic enhancement of complex formation. The intensity of the alterations was discovered to be dependent on the pattern and course of the disease.
Asunto(s)
Complejo Antígeno-Anticuerpo/sangre , Vasculitis por IgA/inmunología , Sistema Inmunológico/inmunología , Adolescente , Adulto , Anciano , Linfocitos B/inmunología , Niño , Femenino , Humanos , Vasculitis por IgA/complicaciones , Inmunoglobulinas/análisis , Masculino , Persona de Mediana Edad , Formación de Roseta , Linfocitos T/inmunologíaRESUMEN
The level and possible pathologic relevance of circulating immune complexes (ICs) were investigated by polyethylene glycol precipitation method in sera of 109 untreated cancer patients (melanoblastoma, lung and breast cancer) and 118 patients with various immune complex diseases (collagenosis, nephropathia, vasculitis and immune hemocytopenia). The highest level of ICs was established in all patients with melanoblastoma. The raised concentration of ICs was registered in patients with malignancies of lung and breast (42 and 44%, respectively). A relationship between increased level of ICs and the rate of its growth in breast cancer patients, on the one hand, and clinical stage of the disease, on the other, was shown. The pathogenic effects of ICs in malignancies and immune complex diseases are compared.