RESUMEN
In this study efficacy of antineoplastic action of gadolinium NCT and boron NCT in cases of canine melanoma and osteosarcoma was compared. Canine spontaneous tumors, such as melanoma and osteosarcoma, have clinical common features with human malignancies, so these tumors in dogs can be considered as clinical model of human melanoma and osteosarcoma. The study has been carried out on 33 dogs with oral cavity melanoma and 9 dogs with osteosarcoma. Dogs with spontaneous melanoma of oral cavity and osteosarcoma of extremities were selected by the results of clinical examination. Irradiation was carried out at the NCT facility of the IRT MEPhI reactor. Neutron irradiation without boron or gadolinium was chosen as a control method to evaluate the efficacy of NCT.
Asunto(s)
Terapia por Captura de Neutrón de Boro/veterinaria , Enfermedades de los Perros/radioterapia , Neoplasias/veterinaria , Terapia por Captura de Neutrón/veterinaria , Animales , Neoplasias Óseas/radioterapia , Neoplasias Óseas/veterinaria , Compuestos de Boro/uso terapéutico , Terapia Combinada , Enfermedades de los Perros/terapia , Perros , Gadolinio/uso terapéutico , Humanos , Melanoma/radioterapia , Melanoma/veterinaria , Neoplasias de la Boca/radioterapia , Neoplasias de la Boca/veterinaria , Neoplasias/radioterapia , Neoplasias/terapia , Osteosarcoma/radioterapia , Osteosarcoma/veterinaria , Fenilalanina/análogos & derivados , Fenilalanina/uso terapéuticoRESUMEN
The purpose of the work was to build a prompt gamma neutron activation analysis (PGNAA) facility at the MEPhI reactor for analyzing the content of various elements for NCT. The facility was implemented on a monochromatic neutron beam. Methods of quantitative (10)B and Gd measurement have been developed for pharmacokinetic studies. The facility is capable of measuring 1 microg of (10)B and 10 microg of Gd in biological samples with an error less than 10%. The detection limit of the facility is 0.3 microg of (10)B and 2 microg of Gd. Neutron flux attenuation within biological tissue samples was estimated and a new system for determining the elemental concentration was suggested.