Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
1.
Intern Med ; 53(3): 205-13, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24492688

RESUMEN

OBJECTIVE: Disseminated intravascular coagulation (DIC) is a clinical condition with high mortality that is characterized by the systemic activation of coagulation pathways resulting in multiple organ failure. Although no standard treatment for DIC has been established, recent reports have indicated that recombinant human soluble thrombomodulin (rTM) is effective against DIC. METHODS: To elucidate the clinical characteristics and outcomes of DIC, we retrospectively analyzed 92 DIC patients who were treated with rTM at Miyazaki Prefectural Hospital over a 4-year period (62 patients had infectious diseases and 30 patients had hematological diseases). A diagnosis of DIC was made based on the diagnostic criteria of the Japanese Association for Acute Medicine (JAAM) and Japanese Ministry of Health and Welfare (JMHW) for infectious diseases and hematological diseases, respectively. In addition to treating the underlying disease, rTM was administered for six consecutive days. RESULTS: In this study, 49 of the 92 DIC patients (53.3%) experienced resolution of DIC seven days after administration (46.8% patients with infectious disease and 66.7% with hematological disease). A higher survival rate was observed after a 28-day observation period in 69 of the 92 patients (75.0%) (72.6% of the patients with infectious disease and 80.0% of the patients with hematological disease). A lower DIC score at the initiation of rTM treatment was closely related to a higher rate of resolution of DIC. CONCLUSION: Our findings indicate that rTM therapy is an effective, safe and feasible treatment for DIC patients. Furthermore, making an accurate and early diagnosis of DIC and providing subsequent immediate treatment with rTM may improve the resolution of DIC.


Asunto(s)
Enfermedades Transmisibles/tratamiento farmacológico , Coagulación Intravascular Diseminada/tratamiento farmacológico , Enfermedades Hematológicas/tratamiento farmacológico , Trombomodulina/uso terapéutico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Enfermedades Transmisibles/diagnóstico , Enfermedades Transmisibles/mortalidad , Coagulación Intravascular Diseminada/diagnóstico , Coagulación Intravascular Diseminada/mortalidad , Femenino , Enfermedades Hematológicas/diagnóstico , Enfermedades Hematológicas/mortalidad , Humanos , Masculino , Persona de Mediana Edad , Mortalidad/tendencias , Proteínas Recombinantes/uso terapéutico , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven
2.
J Clin Virol ; 51(1): 68-72, 2011 May.
Artículo en Inglés | MEDLINE | ID: mdl-21324735

RESUMEN

BACKGROUND: Definitive diagnosis is crucial in reducing morbidity and mortality from pandemic influenza A H1N1 2009 (A/H1N1/2009), especially in high-risk populations. We recently developed a rapid diagnosis kit (RDK) capable of specifically detecting A/H1N1/2009. OBJECTIVES: To evaluate the diagnostic capability of the RDK in a multicenter, prospective trial. STUDY DESIGN: Samples were obtained by nasal swab from patients with suspected influenza. The diagnostic capability of the RDK was compared with that of the standard, real-time reverse transcription-polymerase chain reaction (RT-PCR) method. RESULTS: Of 266 patients who met the criteria, 122 and 92 were positive for A/H1N1/2009 influenza by PCR and by the newly developed RDK, respectively. The sensitivity, specificity and positive and negative predictive values of the RDK were 73.0%, 97.9%, 96.7% and 81.0%, respectively. A/H1N1/2009 detection rates by the RDK were significantly lower in samples obtained from patients more than 3 days after onset than in samples obtained between 1 and 2 days. CONCLUSIONS: The A/H1N1/2009-specific RDK is a reliable test that can be used easily at a patient's bedside for rapid diagnosis of A/H1N1/2009. This test will be of key importance in the control of A/H1N1/2009.


Asunto(s)
Anticuerpos Monoclonales/inmunología , Antígenos Virales/inmunología , Subtipo H1N1 del Virus de la Influenza A/aislamiento & purificación , Gripe Humana/diagnóstico , Juego de Reactivos para Diagnóstico/normas , Adolescente , Distribución por Edad , Niño , Preescolar , Cromatografía de Afinidad , Intervalos de Confianza , Femenino , Humanos , Lactante , Subtipo H1N1 del Virus de la Influenza A/inmunología , Gripe Humana/inmunología , Gripe Humana/virología , Japón , Masculino , Pandemias , Estudios Prospectivos , Juego de Reactivos para Diagnóstico/virología , Sensibilidad y Especificidad , Distribución por Sexo , Factores de Tiempo
3.
Pediatr Infect Dis J ; 23(1): 74-6, 2004 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-14743053

RESUMEN

A previously healthy boy developed persistent hepatitis without fever or lymphoproliferative disorder. Although serologic tests were not indicative, Epstein-Barr virus (EBV) genome and transcripts were detected from the liver tissue, and real time PCR detected extremely high levels of EBV viremia. EBV infection should be included in the differential diagnoses of hepatitis of unknown etiology, even with unremarkable serologic data.


Asunto(s)
Infecciones por Virus de Epstein-Barr/diagnóstico , Hepatitis/virología , Herpesvirus Humano 4/aislamiento & purificación , Biopsia con Aguja , Preescolar , Enfermedad Crónica , Infecciones por Virus de Epstein-Barr/complicaciones , Estudios de Seguimiento , Hepatitis/complicaciones , Hepatitis/tratamiento farmacológico , Humanos , Pruebas de Función Hepática , Masculino , Prednisolona/administración & dosificación , ARN Viral/análisis , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Medición de Riesgo , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA