RESUMEN
Comparative evaluation of effectivennes and safety of the local hemostatic agents in the experiment. On the model side damage the femoral artery of pigs we performed a comperative test of modern local hemostatic agents (LHA): bandages on the basis of chitosan <
Asunto(s)
Vendajes , Arteria Femoral/lesiones , Hemorragia/terapia , Hemostáticos/uso terapéutico , Animales , Evaluación Preclínica de Medicamentos , Femenino , Hemostáticos/efectos adversos , Humanos , Masculino , PorcinosRESUMEN
On selection of external bleeding models for preclinical evaluation of the effectiveness of local haemostatic agents (literature review). To temporarily stop of external bleeding traditionally use a pressure bandage or tourniquet, but not for all types of wounds it is possible and appropriate to apply these dressings. In recent times there has been significant progress in the development and improvement of local haemostatic agents used for the first aid. There are currently conflicting information about their effectiveness, presented by various authors, requires standardization of experimental modelsforpre-clinical testing of medical devices in this class. Following a review of domestic and foreign literature DroDosed to standardize external bleeding model for assessing the effectiveness of local haemostatic agents.
Asunto(s)
Modelos Animales de Enfermedad , Hemorragia/tratamiento farmacológico , Técnicas Hemostáticas , Hemostáticos/uso terapéutico , Animales , Evaluación Preclínica de Medicamentos/métodos , Hemorragia/patología , Hemorragia/fisiopatología , HumanosRESUMEN
With the help of tests on 10 big biological objects (sheep) was studied a modern model of severe lateral damage (6 mm diameter) of femoral artery. Within 45 seconds blood loss was 432.5 +/- 258.2 ml. The usage of domestic local hemostatic agent--"Gemostop" based on zeolite and "Gemofleks" based on chitosan. The total three-hour mortality was 50%. Primary hemostasis was recorded only in 20% of biological objects, the final hemostasis in 60%. Thus, the model of standard 6-mm lateral damage of femoral artery with a free primary hemmorage during 45 seconds should be considered as. optimal for evaluating the effectiveness of modern hemostatic agents.
Asunto(s)
Arteria Femoral/lesiones , Hemorragia/prevención & control , Técnicas Hemostáticas , Hemostáticos/uso terapéutico , Ovinos , Heridas Penetrantes/complicaciones , Administración Tópica , Animales , Modelos Animales de Enfermedad , Femenino , Hemostáticos/administración & dosificación , Resultado del TratamientoRESUMEN
The state research and test institute of military medicine of the Ministry of Defence of the Russian Federation celebrates the 85th anniversary. The article is devoted to the anniversary of the newly reconstituted state research and test institute of Military Medicine of the Ministry of Defence of the Russian Federation. The institute was closed down in 2011 and worked exclusively as a structural subdivision of the Kirov Military Medical Academy for tests of ergonomic characteristics of a weapon and military equipment. Recreation of the institute allowed to engage highly qualified personnel and change the range of tasks, identified prospects of fundamental and applied researches in the field of development of hemostatic agents and anaesthetics, physiology of military work, medical robotics, development of technical means for medical services, and development of new medical technologies. The authors formulated prospects of development of the institution and its participation in the implementation of the primary tasks of the Medical Service to preserve and improve the health of military personnel.