RESUMEN
Intra-abdominal sepsis was induced by open cecal ligation and puncture (OCLP) technique. Sixty rats were randomly divided into three equal groups each of 20. G1 was used as a control. G2 were subjected to laparotomy and closure after 12 hours from (OCLP) via the same incision. In G3, pneumoperitoneum was induced 12 hours after OCLP and maintained at 12 mmHg for about 30 minutes. Blood samples were taken for liver functions after 12 & 24 hours from OCLP procedure, and Liver biopsies were taken for histopathological examination after 24 hours. The results showed that liver functions were markedly increased in G3 after pneumoperitoneum, compared to Gs 1 & 2. The histopathological changes in liver biopsies due to sepsis were more marked in cases exposed to pneumoperitoneum than that exposed to conventional laparotomy. The intra-abdominal sepsis affected liver functions and caused pathogenesis. The increased intra-abdominal pressure induced more liver insults, compared to that gained after open surgery.
Asunto(s)
Hígado/patología , Hígado/fisiología , Neumoperitoneo Artificial/efectos adversos , Sepsis/patología , Abdomen , Animales , Ciego/cirugía , Modelos Animales de Enfermedad , Laparotomía/métodos , Masculino , Punciones , Distribución Aleatoria , Ratas , Ratas Wistar , Sepsis/cirugíaRESUMEN
The policy of elective repair of umbilical hernia in cirrhotic ascitic patients has long been a subject of debate and is still a major health problem. This study evaluated the role and outcome of elective mesh repair of umbilical hernia in cirrhotic ascitic patients, compared with the conventional two layers fascial repair technique. Forty cases with a small to medium sized umbilical hernia defects in ascitic cirrhotic patients were divided into two groups (GI & GII) of 20 patients each. After proper control of ascites in both groups, patients in GI were subjected to elective umbilical hernia onlay mesh repair. In GII, hernias were managed by conventional two layers fascial repair. In GI, transient early postoperative ascitic fluid leakage occurred in 3 (15%) cases and mild superficial wound infection in 5 (25%) cases which was controlled by antibiotics. Two (10%) cases developed hernia recurrence during follow up period. In GII, ascitic leakage occurred in 6 (30%) cases that responded well to conservative management except only one case needed re-exploration and repair reenforcement. Drainage was significantly less than in GI in amount (P<0.05) and duration (P<0.01), wound infection occurred in 3 (15%) cases but were superficial and controlled conservatively. Recurrence occurred in 7 cases (35%). Elective mesh repair of umbilical hernia with ascites in cirrhotic patients proved to be a safe, simple and effective technique with perioperative antibiotics and proper aseptic procedure.