RESUMEN
OBJECTIVE: To match Michigan birth and newborn screening records to identify and follow-up potentially unscreened infants, assess data quality, and demonstrate the utility of Link Plus linkage software for matching MCH related administrative datasets. METHODS: Birth and newborn screening records maintained by the Michigan Department of Community Health from January 2007 through March 2008 were used in this study. Link Plus, a freely-available probabilistic record linkage software program developed at the Centers for Disease Control and Prevention, was used to match records. Linkage performance was assessed by the linkage success rate (percentage of valid matches). Follow-up of un-matched records was conducted by the Michigan Newborn Screening Follow-up Program. RESULTS: Nearly all (99.2%) of the 142,178 birth records included in this study were successfully matched to newborn screening records. Following a transition to a web-based electronic birth certificate system and inclusion of a newborn screening card identification number on the birth record in 2008, the linkage success rate increased to 99.6% based on analysis of approximately 18,000 records. Of approximately 600 un-matched records, nearly half had received a newborn screen. Approximately 8% of un-matched records were due to parental refusal of newborn screening. Nine children received an initial screen as a result of this study; one was confirmed as having sickle cell trait. CONCLUSIONS: We have demonstrated that a freely available record linkage software, Link Plus, can be used to successfully match records of MCH databases thereby providing an opportunity for further research and quality assurance investigations.
Asunto(s)
Certificado de Nacimiento , Recolección de Datos/métodos , Nacimiento Vivo , Registro Médico Coordinado/métodos , Tamizaje Neonatal , Estudios Transversales , Registros Electrónicos de Salud , Estudios de Seguimiento , Humanos , Recién Nacido , Internet/organización & administración , Nacimiento Vivo/epidemiología , Michigan/epidemiología , Tamizaje Neonatal/organización & administración , Sistemas de Identificación de Pacientes , Proyectos Piloto , Desarrollo de Programa , Evaluación de Programas y Proyectos de Salud , Sistema de Registros , Programas Informáticos/normas , Integración de SistemasRESUMEN
Metrizamide is a water-soluble contrast medium used as a diagnostic tool in myelography and cisternography. Despite its accepted safety, its use has been associated with generalized motor seizures, and several cases of this toxicity have been reported. Risk factors include phenothiazine ingestion, seizure history, and large doses of the contrast material. Abnormal electroencephalographic wave patterns, as well as seizure activity, are less frequent after cisternography than myelography. A case of a metrizamide-induced generalized motor seizure following cisternography is reported in a patient with none of the above risk factors. The need for a thorough medication history and the use of prophylactic anticonvulsants in selected patients is discussed.
Asunto(s)
Metrizamida/efectos adversos , Mielografía/efectos adversos , Convulsiones/inducido químicamente , Rinorrea de Líquido Cefalorraquídeo/diagnóstico por imagen , Electroencefalografía , Epilepsia Tónico-Clónica/inducido químicamente , Femenino , Humanos , Persona de Mediana Edad , RiesgoRESUMEN
Recent evidence suggests a genetic mode of transmission of Parkinson's disease. A multifactorial mechanism is likely, but autosomal dominance with reduced penetrance has not been excluded. The distribution of ancestral second-degree relatives with Parkinson's disease was evaluated in 12 families. Affected relatives were bilaterally distributed more often than would be expected for autosomal dominance. The distribution of ancestral secondary cases suggests a multifactorial etiology for most cases of Parkinson's disease. The possibility of dominant gene inheritance in some families is not entirely ruled out.